Abstract:"Thermal Neutron Analysis (TNA) is a non-intrusive detection technique that can specifically detect landmines by measuring the high nitrogen density in the explosives. This technique is well suited for a confirmatory sensor that can work in conjunction withexisting anomaly mine detection sensors,… more
Abstract:DESCRIPTION (provided by applicant): Liver toxicity is the most common cause for failure in new drug development except for efficacy failures. To address this problem, we have developed a series of tests measuring basic events in cellular toxicity using a patented human liver cell line:… more
Abstract:A new generation of Ka-band helical traveling wave tube (TWT) power amplifiers with efficiencies of over 60% will be developed. The dramatic increase in efficiency over current state-of-the-art amplifiers with about 45% efficiency will be achieved by the introduction of a novel taper to suppress all… more
Abstract:A new generation of Ka-band helical traveling wave tube (TWT) power amplifiers with efficiencies of over 60% will be developed. The dramatic increase in efficiency over current state-of-the-art amplifiers with about 45% efficiency will be achieved by the introduction of a novel taper to suppress all… more
Abstract:The Alchemist system we are proposing is a combined-cycle system which reduces Reusable Launch Vehicle (RLV) liftoff weights by a factor of four relative to all-rocket systems. This reduces the weight of major elements (e.g. Jet engines, wing, and landing gear)by 60%, and allows us the margin to use… more
Abstract:The Alchemist system we are proposing is a combined-cycle system which reduces Reusable Launch Vehicle (RLV) liftoff weights by a factor of four relative to all-rocket systems. This reduces the weight of major elements (e.g. Jet engines, wing, and landing gear)by 60%, and allows us the margin to use… more
Abstract:"This effort is to develop, optimize, and demonstrate a suite of physics formalisms, codes, and novel techniques for designing complex antennas such as multi-function arrays recessed in airframe surfaces and shipboard composite masts that may incorporateradomes and Frequency Selective Surfaces (FSS)… more
Abstract:"This exploratory research focuses on the development of a robust validation methodology that bridges the gap between component-level EM phenomenology understanding and accurate system-level analysis of complex aircraft-stores problems. A novel EMITPapproach determines the appropriate steps for… more
Abstract:DESCRIPTION (provided by the applicant): Prostate cancer is the most frequently
diagnosed cancer in American men and the second leading cause of male cancer
death. Antiandrogens have been used with castration to prevent the progression
of prostate cancer. However, cancer relapse… more
Abstract:DESCRIPTION (provided by applicant): Androgen blockage therapy may relieve the symptom of an advanced, localized prostate tumor; however, once the tumor evolves into a hormone-refractory stage, there is no effective treatment. A continuous activation of AR by antiandrogens (used in androgen blockage… more
Abstract:DESCRIPTION (provided by applicant): Recent studies support the concept that treatment with scatter factor/hepatocyte growth factor can prevent renal dysfunction in mouse models of renal failure. SF/HGF has multiple actions such as proliferative, pro-fibrinolytic and anti-apoptotic activities that… more
Abstract:Numerous novel approaches to cancer therapy are currently being examined including gene therapy, immunotherapy and combinations of traditional and novel therapies. By targeting multiple events in the proliferation and spread of cancer cells the effectiveness of treatments may be improved and… more
Abstract:Cardiovascular disease is the leading cause of morbidity and mortality in the US, afflicting over 58 million Americans. Angiogenic factors can increase vascularization and improve perfusion in ischemia. Scatter factor/hepatocyte growth factor (SF/HGF) may be superior to other angiogenic factors… more
Abstract:Cardiovascular disease is the leading cause of morbidity and mortality in the US, afflicting over 58 million Americans. Angiogenic factors can increase vascularization and improve perfusion in ischemia. Scatter factor/hepatocyte growth factor (SF/HGF) may be superior to other angiogenic factors… more
Abstract:"This Phase II project will develop and validate a computerizedtool (Scenario Design and Assessment Tool for Training) to assistinstructors in designing mission scenarios for use in simulatortraining. ScenDATT is an integrated scenario design andeducational tool that takes Navy courseware developers… more
Abstract:"The objective of this Phase I effort is to design an Intelligent Advisor for Human-Computer Interface Design (IAHCID) in preparation for demonstration of a prototype system in Phase II. IAHCID will provide the HCI design team with rapid accessibility tothe enormous array of existing design data,… more
Abstract:"Multi-tasking requires dealing with information from multiple sources under time constraints and is critical for successful (i.e., safe) performance in many occupations. The primary objective of Phase I will be to design a reliable and valid measure ofthe ability to learn and perform jobs that… more
Abstract:"This Phase II will develop the Warfighter Analysis & Readiness System for Mission Unit-Level Planning (WARMUP). WARMUP is an information technology capability designed to support a continuing cycle of mission analysis throughout planning, briefing,execution, and debriefing. Though developed for use… more
Abstract:"This Phase II will develop the Warfighter Analysis & Readiness System for Mission Unit-Level Planning (WARMUP). WARMUP is an information technology capability designed to support a continuing cycle of mission analysis throughout planning, briefing,execution, and debriefing. Though developed for use… more
Abstract:"As the military assumes more missions involving operations other than war (including humanitarian operations and support to domestic authorities), more of our military leaders will need to become proficient in coalition and collaborative leadershipenvironments. Success in such operations, including… more
Abstract:Clinical susceptibility testing of anaerobes has long been complicated by the lack of reproducible growth and prolonged incubation times. Adding to the complexity, antibiotic resistance in anaerobes is a growing and unpredictable problem. We hypothesize that current growth inconsistencies and… more
Abstract:DESCRIPTION (Provided by applicant): Due to the anticipated significant increase in the number of potential vaccines for CDC Category A agents in the near future, it is imperative that a rapid response quality control technology be developed and validated. The key objective of this proposal is to… more
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