Abstract:DESCRIPTION (provided by applicant):Single Photon Emission Computed Tomography (SPECT) is a powerful, non-invasive medical imaging technique which provides an image of the three-dimensional distribution of radionuclide in any slice through an organ under study in the body. These images allow… more
Abstract:DESCRIPTION (provided by applicant):Radiation Monitoring Devices, Inc. proposes to design a simple, high speed, highly sensitive viral detection instrument. This instrument will measure fluorogenic reporter genes, which hybridize to complementary viral gene target inside a capillary waveguide. Our… more
Abstract:DESCRIPTION (provided by applicant):The gamma ray scintillation camera is the instrument of choice for imaging both static and dynamic radioisotope distributions in vivo. Radionuclide imaging conducted using gamma cameras is used to obtain information about functionality, morphology, and metabolic… more
Abstract:Delta-9-tetrahydrocannibinol (THC) is approved for AIDS-related anorexia, chemotherapy-related nausea and vomiting, and clinical evidence supports efficacy of THC in pain, even suggesting an opioid sparing strategy with equivalent analgesia. Current THC formulations have significant disadvantages,… more
Abstract:DESCRIPTION (provided by applicant): Migraine is a serious condition affecting millions of Americans. Patients with migraine strongly desire more rapid headache relief than current medications provide. A promising approach to expediting pain relief is delivery of existing drugs to the systemic… more
Abstract:Description (provided by applicant): The liver is the most important organ in metabolizing xenobiotics and drugs. Liver cells (hepatocytes) are used frequently in testing drug metabolism and hepatotoxicity. Hepatocytes in culture can form spheroids that exhibit higher liver-specific functions and… more
Abstract:"The next-generation of military and commercial turbine engines will operate at higher speeds; higher pressure-ratio and higher cycle temperature to achieve increased power and engine efficiency. As a result, advanced bearings capable of operating above 3.0MDN under severe loading are required… more
Abstract:70080 Volumetric growth in present day pixel detectors, coupled with increased detector thermal heat load and attendant cooling system complexity, is presenting severe design and performance limitation to fulfilling the needs of precision tracking. The structural and cooling system designs… more
Abstract:"Allcomp proposes to design and develop innovative insulative carbon-foam cores for the hot structure of the next generation missiles and re-entry vehicles. Typical heatshield and re-entry structures encounter high heat flux and dynamic loads in theoperational environment. Conventional… more
Abstract:The objective of this proposal is to develop a quantitative ELISA assay for quantitative measurement of anti-RhD antibodies. Specific aims include isolation of soluble serologically active RhD, coating ELISA plates with the extract, enhancing the sensitivity of antibody detection using the… more
Abstract:DESCRIPTION (provided by applicant): The objective of this proposal is to demonstrate the feasibility of a new approach to improving the performance of bio-molecular imaging methods. A new technology allows one to increase the signal-to-noise ratio, save costly reagents and reduce time of analysis… more
Abstract:"The objective of this proposal is to describe an automated (or semi-automated) lightweight, low-cost handling system for lauch & recovery of offboard vehicles which can be fitted to existing Navy ships or designed into new classes of ships. Many of thesystems required for this effort are either in… more
Abstract:DESCRIPTION (provided by applicant): The incidence of allergic diseases such as
atopic dermatitis (AD) has been dramatically increasing in the US and other
industrialized countries for the past two decades. We and others have
demonstrated that Tec family protein-tyrosine kinases have crucial roles… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a surface coating technology that will be used to create improved materials for regulating cell behavior for research, tissue engineering and cell therapy applications. For these applications, advanced materials are needed… more
Abstract:"It is proposed to develop simplified composite analytical procedure (SAP) for naval joint design that will perform: 1) material constituent analysis (MCA), 2) material uncertainty analysis (MUA), and fracture damage, and the percentage contribution of eachmaterial constituent to failure mechanisms.… more
Abstract:"Airborne systems for ground surveillance of mobile targets provde ever more significant tactical information for military operations. Fusion of ground moving target indicator (GMTI) radar data from multiple airborne platforms with overlapping fields ofregard can improve tracking of moving ground… more
Abstract:"It is widely recognized that improved real-time dynamic retasking of airborne Intelligence Surveillance Reconnaissance sensors is needed to enable rapid information gathering in support of tactical battlefield operations. Proposed Air Force modernizationplans feature a distributed C2 architecture… more
Abstract:"We propose to develop advanced multi-sensor multi-target out-of-sequence measurement (OOSM) filtering and data association algorithms using a central tracking architecture, evaluate their performance, and implement the algorithms in ALPHATECH's extensivelytested and evaluated GMTI Precision Fire… more
Abstract:"Distributed autonomous cooperative control is required to realize the full potential of autonomous assets in a tactical operational setting. For a tactical battlespace, there are many levels of applications requiring cooperative control. This researchaddresses the mission control level where the… more
Abstract:"In our Phase I study we developed and evaluated several initial approaches to fusing multiple-looks for SAR combat ID. Extensive evaluation of decision-level multi-look fusion showed there were significant performance benefits compared with single lookID. In Phase I of this SBIR, we developed and… more
Abstract:"Recent studies have shown that the performance of Space-Time Adaptive Processing (STAP) degrades when there are moving targets in the secondary training data. Although a variety of techniques have been proposed for controlling the effects of targets inthe secondary data (TSD), these techniques… more
Abstract:"Shipboard intelligence centers deployed in littoral regions arethe "front line" for naval intelligence gathering. Onboardcryptanalysts need to monitor multiple information sources fortrends and deviations from expected norms, detect and properlyinterpret the unusual, and generate Indications and… more
Abstract:"Effects-based operations must determine how the enemy might respond to air strikes. Current approaches to predicting enemy response to target damage suffer from serious limitations: they typically do not consider how the enemy might repair or modify thestructure of a target system, they typically… more
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