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Year:2002
Company: APES, INC. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "Fretting is a wear phenomenon that occurs between two mating surfaces: it is adhesive in nature, and vibration is its essential causative factor. Usually fretting is accompanied by corrosion. In general, fretting occurs between two tight fitting surfacesthat are subjected to a cyclic, relative… more
Company: APHIOS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): Marijuana (Cannabis sativa) and a number
of cannabinoids including its primary psychoactive component, delta9-THC
(delta9-tetrahydrocannabinol), show promise for treating pain and cachexia in
cancer and AIDS patients. The overall goal of this research program is… more
Company: APL Sciences, Inc. Agency/Program/Year/Phase: USDA / SBIR / 2002 / 1
Abstract: Species identification of blue crabmeat is necessary for the detection of inappropriately labeled products. Atlantic blue crab is the most valuable crab industry in the United States. Due to its high cost, popularity and demand Atlantic blue crab meat is susceptible to substitition using less… more
Company: Apocom, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2002 / 1
Abstract: 70677 The use of microarrays is rapidly expanding as a tool to support gene functionality and expression studies. However, these microarrays, which can now accommodate tens of thousands of genes in a single experiment, are spewing out a tidal wave of data that is causing a bottleneck to… more
Company: APOGEE BIOTECHNOLOGY CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: Cancer chemotherapy often provides temporary clinical improvement. However, tumor cells that survive the initial treatment often develop into cancers with multiple drug resistance (MDR). This is most often mediated by increased levels of the transport protein P-glycoprotein (PgP). A related family… more
Company: APOGEE BIOTECHNOLOGY CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: Current treatment protocols for AIDS involve combinations of nucleoside analogs and HIV protease inhibitors, but are not successful in curing the disease. The drug transport protein, P-glycoprotein (Pgp) effluxes a wide variety of drugs, including all FDA-approved protease inhibitors. A growing… more
Company: APOIMMUNE, INC Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by the applicant): Bone marrow transfusion (BMT) holds
the potential to cure many blood diseases. However, BMT recipients often
develop graft-versus-host disease (GvHD), a life-threatening condition in which
immune cells from the infused transplant attack the recipient's… more
Company: APOLLO INSTRUMENTS, INC. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "We propose to develop kilowatt fiber lasers that is highly efficient at the conversion of electrical power into a diffraction-limited laser beam. The overall goal of this program is to deliver an unprecedented kilowatt-class fiber laser. The laser will becompact in size and light in weight. The… more
Company: APOLLO LIGHT SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): Multiple studies have established that bright light therapy is effective in alleviating symptoms of winter depression (seasonal affective disorder, or SAD). Light units used for treating SAD in the past have generally emitted polychromatic white light of highly… more
Company: APOLOGIC, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: The strategy proposed here for developing novel therapies for treating Alzheimer's disease is based on the finding that neurotoxic and amyloid-depositing fragments apolipoprotein E may play a role in this disease. This, in turn, suggests that degradation of this protein contributes to the… more
Company: Appa Technology Initiatives Agency/Program/Year/Phase: NASA / SBIR / 2002 / 1
Abstract: This innovation describes an economical approach to improve the fatigue life of aircraft components that are subjected to dynamic load environment. Prolonged exposures to buffeting causes sever fatigue damage resulting in catastrophic failure of vertical tails of combat aircraft such as F18, F15,… more
Company: Appcom, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "Increased demands for data capacity, combined with increasingly limited spectral resources, are rapidly exceeding the capabilities of current communications systems in the battlefield. As in the commercial sector, the nature of the data demand isincreasingly multimedia, with a variety of… more
Company: Appcom, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "Implementing a wireless LAN system for dismounted soldiers presents a number of problems that distinguish it from a commercial LAN system. Some of these unique, difficult problems include the lack of any in-place network support system, severe multi-pathand fading conditions, and mobility… more
Company: Applicable Electronics, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2002 / 2
Abstract: 65519 The corrosion of metal alloys used in energy production and conservation limits the lifetime of components made from these materials. The metal surfaces are protected by passive oxide layers, yet basic questions about how these layers break down and initiate corrosion are not answered. … more
Company: Applicable Electronics, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2002 / 1
Abstract: 65519 The corrosion of metal alloys used in energy production and conservation limits the lifetime of components made from these materials. The metal surfaces are protected by passive oxide layers, yet basic questions about how these layers break down and initiate corrosion are not answered. … more
Company: Applied Ceramics Research Co. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 2
Abstract: "The use of high dielectric constant materials in semiconductor integrated circuits is greatly expanded due to their obvious advantage of providing higher capacitance per unit area compared to the more conventional silicon oxide/silicon nitride capacitors.There are at least three general areas where… more
Company: APPLIED COATINGS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 2
Abstract: DESCRIPTION (provided by applicant): Efforts will be made to produce Thin Film Phantom systems that enables the precise placement of sub-resolvable 'digital scatterers' on a acoustically transparent supporting media in a tissue mimicking fluid. Research will include not only the continued study on… more
Company: APPLIED COATINGS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): Efforts will be made to produce Thin Film Phantom systems that enables the precise placement of sub-resolvable 'digital scatterers' on a acoustically transparent supporting media in a tissue mimicking fluid. Research will include not only the continued study on… more
Company: Applied EM Inc. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 2
Abstract: "There is a great need for multifunctional communication arraysthat are small and fit within a specified submarine enclosure.Concurrent low and high frequency functionality presents us withadditional challenges. We propose herein the development of abroadband multifunctional array for operation when… more
Company: Applied EM Inc. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "With the availability of fast and powerful computational facilities, we are now able to characterize full-scale vehicles. However, recent developments in fast methods and the availability of new hybrid methods that combine integral, differential and highfrequency methods, have yet to be exploited… more
Company: Applied EM Inc. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "Satellite communications has advanced remarkably and applications are now expanding rapidly, particularly in the use of very small aperture terminals (VSATs). In many instances, military forces are required to establish and maintain communications viaSATCOM (using VSATs) while stationed temporarily… more
Company: Applied Engineering Solutions, LLC Agency/Program/Year/Phase: DOE / STTR / 2002 / 1
Abstract: 70075 Significant fuel cost savings can be realized in the automotive and aerospace industries by employing lightweight materials in the design and fabrication of vehicular components. To date, the exploitation of magnesium and aluminum alloys in tube and sheet components has been… more
Company: APPLIED GENE TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): Many of the applications of
oligonucleotide arrays, especially the complex and quantitative applications
such as Sequence By Hybridization (SBH) are hampered by errors resulting from
the variable hybridization properties of the small probes and the stability… more
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