Abstract:70747 Instrumentation is needed to quantify all significant sources and sinks of man-made carbon dioxide. This information would in turn enable accurate predictions of the impact of carbon dioxide on the Earth¿s climate. This project will adapt an existing carbon dioxide analyzer to… more
Abstract:The phase I research was successful. An analyzer was designed and built, and it meets all five criteria of the DOC solicitation subtopic. We are proposing to: (1) build and incorporate copies of the analyzer into three detection systems, each to be constructed and customized for a platform of… more
Abstract:The phase I research was successful. An analyzer was designed and built, and it meets all five criteria of the DOC solicitation subtopic. We are proposing to: (1) build and incorporate copies of the analyzer into three detection systems, each to be constructed and customized for a platform of… more
Abstract:70524 In order to predict the bioremediation rate and ecological impact of contaminated sites, a rapid method to determine the microbial community structure is needed. Current approaches are time consuming, labor intensive, and expensive. Microarray gene probe technology exhibits… more
Abstract:DESCRIPTION (provided by applicant): The goal of the proposed project is to develop an analytical tool for large-scale detection of single-nucleotide polymorphisms (SNPs) in unlabeled, unamplified genomic or pooled nucleic acid samples. A dual hybridization utilizing a labeled, peptide nucleic acid… more
Abstract:"Conventional tracking schemes have reached their performance limit for systems such as the Airborne Laser operating in deep turbulence environments. The next generation of high precision tracking systems must exploit all information available to producethe desired track correction. A study of… more
Abstract:"The proposed effort utilizes the experience gained from over 20 years of work performed by the Optical Sciences Company in the areas of atmospheric propagation, wavefront sensing and adaptive optics technology to develop real time adaptive signalprocessors for on-line performance optimization of… more
Abstract:DESCRIPTION (provided by applicant): Anti angiogenic therapy has tremendous potential for the treatment of cancer. Several anti-angiogenic agents currently in clinical trials are large protein domains, which face several challenges for clinical development. Proteins used for anti-angiogenic therapy… more
Abstract:"The objective of this Phase I proposal is evaluate battlespace geolocation correlation opportunities that may be obtained by fusing measurements from Ground Moving Target Indicator (GMTI) and Signals Intelligence (SIGINT) collections. These opportunitiesinclude (1) improving geolocation accuracy at… more
Abstract:DESCRIPTION (provided by applicant): We will continue development of our
Cybertory Virtual Molecular Biology Laboratory software, and create
accompanying instructional materials. New modules will work together to support
a wide range of virtual experiments. We will… more
Abstract:DESCRIPTION (provided by applicant): We will continue development of our
Cybertory Virtual Molecular Biology Laboratory software, and create
accompanying instructional materials. New modules will work together to support
a wide range of virtual experiments. We will… more
Abstract:"This research will provide ability to predict the effectiveness of thermal-basedAgent Defeat weapons. Tasks are compilation of previous experimental data, modeling to estimate the time-temperature conditions produced by selectedAgent Defeat weapons, the design and evaluation of a test system to… more
Abstract:DESCRIPTION (provided by applicant): Whether at home or at an institution,
those unable or unwilling to ask for continence and repositioning assistance
typically receive their care on a schedule that is suggested by various
standards setting organizations based on the best available evidence… more
Abstract:Cancer is the second leading cause of death in the United States. In 2001, nearly 1.3 million Americans were diagnosed with cancer. The goal of this proposal is to establish the pre-clinical relevancy of a proprietary reversible linker, A-Z-CINN/TM, in creating a novel class of targeted pro-drugs… more
Abstract:"Aurora Flight Sciences of West Virginia (AWV) is small business offering a complete range of aerospace structural manufacturing capabilities in both metals and composites. Our largest customer is Northrop Grumman, for whom we manufacture flight-ratedproduction parts for such aircraft as the E8… more
Abstract:"AIS proposes to investigate a COA Knowledge Acquisition (KA) tool that blends a new AI calculus with a developing visualization technology to extend a promising prototype (FOX-GA) to the SASO/ABCS environment. The proposed Course of Action EvaluationSystem (CACES) enables a domain expert to readily… more
Abstract:"The subject design effort will attempt to utilize current technology to produce a feed or feeds capable of operation in the following satellite bands, X-band, Ku-Band, K-band, Ka-band and Q-band. The effort will leverage off past designs to package thefeeds to meet the physical constraints of the… more
Abstract:"Austral Engineering and Software, Inc. proposes continued development of a software application for design criteria management in multiobjective optimization-guided design of sequences of materials proceses. This effort integraesstate-of-the-art-milti-objective optimization algorithms and… more
Abstract:"Austral Engineering and Software, Inc. proposes to develop a strategy and corresponding software for integrating nondestructive evaluation models and simulations through a systems-based approach incorporating optimization-based, computer-aided designtools. Design objectives to be modeled and… more
Abstract:"Work is proposed to demonstrate the feasibility of a catalytic ignition system that can be retrofitted to a light-weight, silent-running, 1 kW generator, allowing it to be satisfactorily operated on heavy fuels such as diesel and JP-8. Gensetmodifications will be closely allied to catalytic… more
Abstract:"The Army has indicated significant need for lightweight, heavy fuel engines for use in a wide variety of battlefield missions. The Catalytic Ignition System (SmartPlugTM) developed and patented by Automotive Resources, Inc. (ARI) promises to fulfill theArmy's "One Fuel Forward" requirement without… more
Abstract:"The proposed research approches the problems of stability, operation mode transfer, and syatem monitoring for multi-modal ground vehicles. The research seeks to provide simple criteria and design frameworks that are applicable to the design of manymultimodal and autonomous vehicle designs. The… more
Abstract:DESCRIPTION (provided by applicant): Of the 5 percent of North Americans who
develop diabetes, 4-15 percent develop macular edema about 8000 per annum
register as legally blind. It is simple for the clinician to diagnosis
localized (rather than diffuse) edema that has a marked (2 fold or… more
Abstract:DESCRIPTION (Provided by applicant): There is a substantial need for a safe,
effective topical treatment for genital herpes simplex (HSV) disease. The
proposed research aims to evaluate feasibility of continued development of
docosanol as a topical treatment for… more
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