Abstract:Cancer is the second leading cause of death in the United States. In 2001, nearly 1.3 million Americans were diagnosed with cancer. The goal of this proposal is to establish the pre-clinical relevancy of a proprietary reversible linker, A-Z-CINN/TM, in creating a novel class of targeted pro-drugs… more
Abstract:"Aurora Flight Sciences of West Virginia (AWV) is small business offering a complete range of aerospace structural manufacturing capabilities in both metals and composites. Our largest customer is Northrop Grumman, for whom we manufacture flight-ratedproduction parts for such aircraft as the E8… more
Abstract:"AIS proposes to investigate a COA Knowledge Acquisition (KA) tool that blends a new AI calculus with a developing visualization technology to extend a promising prototype (FOX-GA) to the SASO/ABCS environment. The proposed Course of Action EvaluationSystem (CACES) enables a domain expert to readily… more
Abstract:"The subject design effort will attempt to utilize current technology to produce a feed or feeds capable of operation in the following satellite bands, X-band, Ku-Band, K-band, Ka-band and Q-band. The effort will leverage off past designs to package thefeeds to meet the physical constraints of the… more
Abstract:"Austral Engineering and Software, Inc. proposes continued development of a software application for design criteria management in multiobjective optimization-guided design of sequences of materials proceses. This effort integraesstate-of-the-art-milti-objective optimization algorithms and… more
Abstract:"Austral Engineering and Software, Inc. proposes to develop a strategy and corresponding software for integrating nondestructive evaluation models and simulations through a systems-based approach incorporating optimization-based, computer-aided designtools. Design objectives to be modeled and… more
Abstract:"Work is proposed to demonstrate the feasibility of a catalytic ignition system that can be retrofitted to a light-weight, silent-running, 1 kW generator, allowing it to be satisfactorily operated on heavy fuels such as diesel and JP-8. Gensetmodifications will be closely allied to catalytic… more
Abstract:"The Army has indicated significant need for lightweight, heavy fuel engines for use in a wide variety of battlefield missions. The Catalytic Ignition System (SmartPlugTM) developed and patented by Automotive Resources, Inc. (ARI) promises to fulfill theArmy's "One Fuel Forward" requirement without… more
Abstract:"The proposed research approches the problems of stability, operation mode transfer, and syatem monitoring for multi-modal ground vehicles. The research seeks to provide simple criteria and design frameworks that are applicable to the design of manymultimodal and autonomous vehicle designs. The… more
Abstract:DESCRIPTION (provided by applicant): Of the 5 percent of North Americans who
develop diabetes, 4-15 percent develop macular edema about 8000 per annum
register as legally blind. It is simple for the clinician to diagnosis
localized (rather than diffuse) edema that has a marked (2 fold or… more
Abstract:DESCRIPTION (Provided by applicant): There is a substantial need for a safe,
effective topical treatment for genital herpes simplex (HSV) disease. The
proposed research aims to evaluate feasibility of continued development of
docosanol as a topical treatment for… more
Abstract:DESCRIPTION (Provided by applicant): There is a substantial need for a safe,
effective topical treatment for genital herpes simplex (HSV) disease. The
proposed research aims to evaluate feasibility of continued development of
docosanol as a topical treatment for… more
Abstract:DESCRIPTION (provided by applicant): The ability to prepare anthrax spores inexpensively and deliver them in an aerosol form, and the high mortality rate of inhalation anthrax, has made Bacillus anthracis one of the most feared agents of biological warfare and terrorism. Despite recent advances in… more
Abstract:"We propose to investigate the feasibility of using Avanti's self-aligning kinematic optoelectronic mounts for active 3-D RF/optoelectronic microstructures. We believe the unique benefit of our approach is the precision alignment of optoelectronic devicesfor coupling to the outside world (and… more
Abstract:"The objective of this proposal is to demonstrate the feasibility of a secure peer-to-peer network environment. Our project, called SCORE (Secure Communication Object Repository Environment), is intended to show that a robust, hardy, secure peer-to-peernetwork environment can meet the needs of the… more
Abstract:DESCRIPTION (provided by applicant): It is proposed to develop an inexpensive,
scalable, and reproducible photolithographic protein immobilization technology
for the fabrication of biosensors and biochips, that will covalently attach
proteins to a surface in a uniform orientation, and that will be… more
Abstract:The proposed research is designed to demonstrate the functionality, safety and effectiveness of an innovative disposable retractable trocar system intended for thoracostomy and chest tube insertion. When tension pneumothorax is suspected, the conventional clinical procedure is to perform a needle… more
Abstract:The proposed research is designed to demonstrate the functionality, safety and effectiveness of an innovative disposable retractable trocar system intended for thoracostomy and chest tube insertion. When tension pneumothorax is suspected, the conventional clinical procedure is to perform a needle… more
Abstract:"New materials and processing techniques are needed to provide a high power storage device for usage in a hybrid electric vehicle (HEV). AVEKA has developed a unique nanophase V205 material that is capable of storing and delivering large amounts of energyin a short period of time. AVEKA will… more
Abstract:"AVEKA, Inc. proposes the use of nanophase aluminum/hydrocarbon slurries produced by its proprietary process with a novel gelling agent to form an inexpensive gelled propellant. AVEKA's Gas Evaporative Reactor (GER) process produces nanophase aluminumslurries in hydrocarbon fluids. These slurries… more
Abstract:"A new compact, lightweight, low-cost, modular, infrared remote sensor of chemical weapon agents will be developed for deployment on expandable UAVs. The sensor will depend on new differential absorption radiometer (DAR) technology that will enabledetection of multiple species, while nearly… more
Abstract:"In order to evaluate the effects of new navigation systems that integrate communications, GPS and augmentation systems, the Air Force needs an Integrated Communications Module (ICM) that dynamically simulates new signals and interfaces with existingsimulators and test equipment. Avtec's Phase I… more
Abstract:"This SBIR seeks to investigate, identify and design adaptive algorithm(s) to enable real-time adaptability for tactical wireless networks. Avtec proposes to develop a "smart software" solution to exploit the real-time adaptability in tactical wirelessnetwork, specifically Link-16, based on… more
Abstract:"We propose to develop a Global Positioning Satellite/Inertial Measurement Unit(GPS/IMU) integrity monitor using techniques that can be implemented in parallel. The first technique takes advantage of the GPS link modulation, namely spreadspectrum coding and bi-phase shift keying. A multiple step… more
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