Abstract:DESCRIPTION (provided by applicant)
"Personalized medicine" is a new clinical paradigm where a specific cancer therapeutic ("smart drug") is prescribed based upon the individual biology of the patient. A goal of personalized medicine is to select individual therapies based upon the correlation of… more
Abstract:DESCRIPTION (provided by applicant): Personalized medicine" is a new clinical paradigm where a specific cancer therapeutic ("smart drug") is prescribed based upon the individual biology of the patient. A goal of personalized medicine is to select individual therapies based upon the correlation of… more
Abstract:DESCRIPTION (provided by applicant): Personalized medicine" is a new clinical paradigm where a specific cancer therapeutic ("smart drug") is prescribed based upon the correlation of proteomic profiles from diseased tissues with patient's response to drug therapy. Many of these new "smart drug"… more
Abstract:DESCRIPTION (provided by applicant): The main objective of this project is to develop membranes with surfaces tailored for specific affinity for a particular protein or nucleic acid molecule. These 'smart' membranes will be used in the next generation of high throughput Layered Expression Scanning… more
Company:A. P. PHARMAAgency/Program/Year/Phase:HHS / SBIR / 2004 / 1
Abstract:DESCRIPTION (provided by applicant): The success of cancer chemotherapy is limited by the concentration of chemotherapeutic agents that can be accumulated in the tumor without exceeding limits imposed by systemic toxicity. Thus, means of altering the biodistribution have to be devised. In our… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this project is the commercialization of a product(s) that enables a substantial improvement in human heart preservation prior to transplantation. The ability to significantly extend human clinical cardiac preservation, to 24 hours or… more
Abstract:Each year over 33,000 human corneas are transplanted in the United States. However, currently available cornea storage protocols affect deleterious changes in all layers of the cornea, which limit permissible local storage times and largely preclude adequate long-distance cornea sharing. The… more
Abstract:DESCRIPTION (provided by applicant): A laser-based acoustic emission (AE) detection device is proposed (Phase I and II) for work site structural stability assessment in order to reduce the occupational injuries and fatalities caused by roof falls, sidewall
crumples, stop collapses, slope slides,… more
Abstract:75867 Mercury (Hg) emissions are an important environmental problem because Hg is a volatile heavy metal that is toxic and bioaccumulates to a high degree in animals and humans. The major sources of Hg emissions include fossil fuel combustion, waste incineration, and chloralkali production. With… more
Abstract:DESCRIPTION (provided by applicant):
Despite new rapid image acquisition techniques high-quality MRI data requires data collection times of several seconds or minutes. Any kind of uncompensated object movement on this time scale will lead to blurring, ghosting or other artifacts in the resulting… more
Abstract:In recent decades, NASA?s interest in spacecraft rendezvous and proximity operations has grown. Additional instrumentation is needed to improve manned docking operations? safety, as well as to enable telerobotic operation of spacecraft or completely autonomous rendezvous and docking. To address this… more
Abstract:DESCRIPTION (provided by applicant): Under two Phase I SBIR grants, Advanced Photodynamic Technologies successfully developed and patented a proprietary PDT technology that has been proven to be effective in the photoablation of antibiotic resistant microorganisms and biofilm that commonly infect… more
Abstract:73089-DOE Office of Defense Nuclear Nonproliferation (NA) applications, especially in the area of software radio, drive wide bandwidths and therefore require high-density super-computing-class I/O, memory, and signal processing capabilities. General-purpose processors do not provide enough… more
Abstract:DESCRIPTION (provided by applicant): This project will develop a package of planning products for radiation treatment that will introduce a measure of quality assurance now lacking, provide clinicians the opportunity to raise tumor dose, and expose the tradeoffs among the treatment constraints and… more
Abstract:The objective of the proposed Phase II effort is to transfer proven sensor technology from the laboratory breadboard to a functional flight-ready prototype for installation in an aircraft fuel tank. In the Phase I effort, a novel spectroscopic technique was shown to be an effective method for… more
Abstract:Laser induced thermal acoustics (LITA) is a nonintrusive, transient-grating optical technique that provides simultaneous high-accuracy measurements of velocity, sound-speed, and thermal diffusivity among other parameters. In a fluid of known composition, sound speed and thermal diffusivity are… more
Abstract:he use of an inter-turbine burner for improving the part power performance of small turboshaft engines in proposed. An inter-turbine burner is a second combustor placed between the gas generator exit and the power turbine to "reheat" the engine gas stream before it enters the power turbine. The… more
Abstract:Progress has been made in the modeling and analysis of the single aircraft shipboard landing task. However, limitations exist in current simulations where the analysis does not include the interference arising from simultaneous operation of multiple aircraft on the same ship. To enhance the modeling… more
Abstract:This Small Business Technology Transfer ( STTR) Phase II project proposes the creation of an Advanced Virtual Manufacturing Lab (AVML) for training and education on high-tech CNC machines. The key elements of the AVML are: (a) textured 3D photo-realistic virtual models of the machines and lab that… more
Abstract:The problem of efficient clutter suppression is a challenge for space-based infrared sensors that have to provide early detection/tracking of missiles launches in cloud solar backgrounds. In such systems, reliable target tracking is impossible without clutter rejection down to/below the level of… more
Abstract:72181-Current and proposed Nuclear Physics (NP) experiments require very accurate measurement of very short-lived phenomena at a very large number of very close measurement locations. Available data acquisition systems use currently available analog-to-digital converter (ADC) technologies, which… more
Abstract:Expandability and upgrade abilities of commercial and military command and control electronic systems are extremely important to minimize cost and efforts required for integration of novel components and subsystems into existing infrastructures. Voltage level converters are the key components for… more
Abstract:The switching fabric (SF) is a key component of the next generation back plane interconnects. Extremely low-power, radiation-hardened, high-bandwidth upgradeable communication between computer nodes is of utmost importance for future NASA missions. The state-of-the-art binary SF interconnect… more
Abstract:This proposal is for the design, fabrication, testing, delivery, and support at ARL of a high-speed high-resolution, real-time, adaptive-optics image-quality analysis system called the High Speed Vision System (HSVS). The proposed innovative smart-sensor technology allows the data on a 512 x 512… more
Abstract:Phase I Isolated two important scenarios for 3-D imaging micro-UAV applications, a long-range open area scenario and a shorter-range under foliage scenario. Readout integrated circuit (ROIC) designs were optimized for these two scenarios. In Phase II the Phase I ROICs will be fabricated and tested… more
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