Abstract:DESCRIPTION (provided by applicant):
Orthotopic liver transplantation is the most effective treatment for patients with end-stage liver disease. Ischemia-reperfusion injury associated with the retrieval, storage and transplantation of livers is a major immune-independent factor adversely… more
Abstract:DESCRIPTION (provided by applicant): Hepatic fibrosis, a disease affecting tens of millions of patients worldwide, is the liver scarring response to chronic injury from viral hepatitis B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress to liver cirrhosis,… more
Abstract:DESCRIPTION (provided by applicant): Renal transplantation is the most effective and cost efficient treatment for patients with established renal disease. However ischemia-reperfusion injury associated with the retrieval, storage and transplantation of kidneys from cadavers is a major… more
Abstract:DESCRIPTION (provided by applicant): Idiopathic pulmonary fibrosis (IPF) is a devastating disease with less than a 50% five-year survival. While steroids and other immunosuppressive agents serve as the standard treatment for IPF, these agents have proved inadequate and have adverse side effects.… more
Abstract:DESCRIPTION (provided by applicant): Atherosclerosis of the cerebral vasculature can produce occlusion and cerebral infarction. Although the tissue in the ischemia core dies within minutes, the surrounding tissue, termed the ischemic penumbra, sustains damage from cytotoxic factors including… more
Abstract:The central goal of research is to develop a commercial test of multi-tasking (MT) ability. The proposed test's utility would be to predict performance in real-world environments that demand high levels of MT activity. In so doing, individuals who are likely to perform well may be selected for… more
Abstract:Non-lethal weapons (NLWs) provide useful options to military commanders in operations other than war such as those currently underway in Iraq and Afghanistan. However, commanders are not well-informed about the psychological and behavioral effects of these weapons on their targets. Relevant data are… more
Abstract:This Small Business Innovation Research Phase II Project proposes to use a newly developed synthetic nanocrystalline hydroxyapatite (HAP) bone material to produce high-strength, resorbable synthetic bone implants for anterior cruciate ligament surgeries. This material solves the problem of current… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of this project is to develop a clinically and commercially viable tissue engineered bone construct using nanocrystalline ceramic scaffolds for proliferating and differentiating adipose-derived progenitor cells into cells of the osteogenic… more
Abstract:The problem that the proposed device/system addresses is the real time in-cylinder pressure and temperature measurement of internal combustion engines. The concept presented is for a multi-task sensor produced using MEMS technology that fits in the cylinder head adjacent to the gasket with its… more
Abstract:DESCRIPTION (provided by applicant): Higher-order structural information for biomolecules is an important component of quality control activities for recombinant proteins. Unfortunately, detailed structural information typically require highly complex, time-consuming experimental techniques (e.g.,… more
Abstract:Wireless technology provides freedom and flexibility to the users of the Local Area Network (LAN). The standards based (IEEE 802.11) wireless LAN equipment is intended to provide reliable coverage over a limited range of approximately 100 m. However, the wireless LAN transmissions may be detected… more
Abstract:This goal is to construct a low-cost, polymeric, nanomaterial-based assay for the detection of multiple biological agents in a single device using our nanomanipulation technology to meet or exceed the sensitivity of the current two-line assays used in DoD applications. The nanodevice will exhibit… more
Abstract:The current generation of field simulation codes are powerful design tools that are highly accurate and can solve small to moderately sized problems. For multi-wavelength structures the options are limited. Examples of application areas where one would find such structures include Rotman lens… more
Abstract:The current generation of field simulation codes are powerful design tools that are highly accurate and can solve moderately sized problems. For multi-wavelength structures the options are limited. Examples of application areas where one would find such structures include Rotman lens design, IC… more
Abstract:We are proposing a helmet-mounted sound localization system that incorporates two subsystems, one that restores and enhances the soldier's natural hearing, and another that makes decisions on the acoustic scene and displays the information to the soldier. The system will integrate auditory… more
Abstract:The ability of remote robotic vehicles to effectively achieve their targeted tasks is dependent, in large part, on how well they can be controlled. The human machine interface and related controls are critical to successful tele-operated and semi-autonomous operations. In Phase I, AnthroTronix,… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of the CosmoBoing! Therapeutic Exercise System is to develop a child-friendly, engaging tool for assuring that children with disabilities participate in and benefit from prescribed therapeutic exercise. The system will serve two populations of… more
Abstract:DESCRIPTION (provided by applicant): The green fluorescent protein (GFP) from Aequorea victoria has been developed into a highly versatile reporter gene. Another family of fluorescent proteins, including Discosoma Red (DsRed), has been cloned from corals (4). This was followed by Anemonia asRed (5)… more
Abstract:`How can one fabricate a sensor that can make different types of measurements on a large area, on a shape that is not known a priori, that is lightweight, that is accurate with a fine resolution, while at the same time has the resolution and sensitivity of a standalone instrument, and at an… more
Abstract:Maskless technology capable of sub-100 nm patterning is attractive for manufacturing of many microelectronic and biomolecular devices. In numerous military applications, the number of different types of electronic modules required is large, whereas the quantities needed of each type of module are… more
Abstract:An integrated unit that harnesses its energy from its surroundings and reacts to, and transmits, any changes in its environment in a predictable and reliable manner would be of significant benefit to the sensor community. Advances in Micro Electro Mechanical Systems (MEMS), silicon, SiGe, and GaAs… more
Abstract:Compound semiconductor films are the key ingredient enabling the construction of ultrafast (>10 GHz) transistors. Materials such as Gallium Arsenide (GaAs), Gallium Nitride (GaN), Silicon Germanium (SiGe) and Indium Phosphide (InP) have shown great potential to enable a quantum leap in transistor… more
Abstract:In this program, we will develop a novel process for fabricating large-area ultraviolet diffraction gratings on curved surfaces. This process is based on a unique conformable maskless projection lithography system technology that has been developed by Anvik Corporation. The UV gratings that will be… more
Abstract:The ability to efficiently utilize the large surface area of entities such as buildings, tanks, and ships as active, intelligent skins will allow these assets to become part of a larger, highly-responsive, complex nervous system in mission critical scenarios. This will enable information that would… more
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