Abstract:DESCRIPTION (provided by applicant): Nanotherapeutics proposes to evaluate oral taurine therapy for Alzheimer's disease (AD). AD, the most common form of dementia among older people, affects over 4 million Americans. It requires full-time care in the end stages and is a significant financial burden… more
Abstract:In this Phase I SBIR Proposal, Nanotherapeutics, Inc. proposes to demonstrate the improved proximity detection of hexamethylene triperoxidediamine (HMTD) and triacetone triperoxide (TATP) explosives using its proprietary NanobreathTM preconcentrator and 4-SAW array. The NanobreathTM 4-SAW Array, a… more
Abstract:Explosively Formed Penetrators (EFPs) are an important component of today's military. They are capable of penetrating many inches (even feet) of armor. Needless to say, high performance is of critical concern and continued improvement requires advanced materials that can perform under severe… more
Abstract:As our military continues to evolve and become more reliant on highly sophisticated equipment, the need for advanced electronics to support their operation is becoming increasingly more important. Clearly, one of the most important transformations is in the area of weapons systems. In fact, the U… more
Abstract:The objective of this proposal is to develop innovative fast switchable (~200ns), wavelength selective, integrated optical true time delay modules based on ultralow loss, athermal and polarization independent waveguide platform with an insertion loss of
Abstract:Future distributed "smart sensor" sonobuoy networks show great potential for use by Naval Antisubmarine Warfare (ASW) forces. Dynamic and scalable network solutions are required to support tens to hundreds of sonobuoys over a regional area, including full interoperability with legacy sensor systems… more
Abstract:DESCRIPTION (provided by applicant):
Blocking or inhibiting tumor blood vessel growth (angiogenesis) remains a critical focal point for anticancer drug development. Studies on Vascular Endothelial Growth Inhibitor (VEGI; TNFSF-15) secreted from human endothelial cells have demonstrated that it is… more
Abstract:DESCRIPTION (provided by applicant): The objective of this proposal is to bioengineer a mutant variant of prourokinase (proUK) with improved therapeutic properties for treatment of acute myocardial infarction(AMI). ProUK is unique among thrombolytic agents in that it is stable as an inert zymogen in… more
Abstract:DESCRIPTION (provided by investigator): Chronic infection with hepatitis B virus (HBV) is associated with a high incidence of liver diseases, including hepatocellular carcinoma (HCC). Hepatitis B virus x antigen (HBxAg), one of the four proteins encoded by the virus, stimulates virus gene expression… more
Abstract:The performance benefits to satellite communication and other systems employing an Electronically Steerable Antenna are numerous. These include rapid beam scanning, increased beam agility, the performance of multiple functions, lighter weight, no angular momentum impact during beam scan and… more
Abstract:We propose to develop a novel aircraft-based sensor system for early launch detection, typing, tracking and kill assessment. In addition to providing enhanced capabilities with respect to current aircraft-based sensors for long range detection over wide areas in clear sky and cloud obscured… more
Abstract:Several plume-hardbody handover algorithms under development by various investigators show promise in simulations for locating the missile body when the body is resolved or approximately the size of a pixel. Several scenarios involving liquid propellant missiles, such as the cases where these… more
Abstract:Phase II would utilize a RDTS sensor and three PSRS sensors to verify the concept and capabilities of an `over the water' intruder detection system. The proposed project would utilize multiple high-resolution radar sensors, with overlapping coverage zones, to detect surface targets. Each radar… more
Abstract:Penetrator bomb damage assessment is particularly difficult to perform since traditional visual reconnaissance methods do not reveal damage below the surface. The AFRL is currently engaged in developing a survivable, low-bandwidth transmitter that will be capable of real-time delivery of penetrator… more
Abstract:This Small Business Innovative Research (SBIR) Phase I project investigates a novel digital approach for modulation and demodulation of FMCW signals in precision radar systems and wideband radios. Recent availability of Silicon Germanium technologies supporting clock speeds of 10 GHz make possible… more
Abstract:DESCRIPTION (provided by applicant): The threats posed by agents of biological warfare have gained increasing attention in light of recent global events. Many early symptoms of infection by agents of biological warfare are indistinguishable from commonly observed diseases. For this reason, rapid,… more
Abstract:The Remote Minehunting System (RMS) AN/WLD-1(V)1 vehicle (RMV) currently does not have a forward-looking sonar (FLS), or any other underwater obstacle avoidance sensor. This means that the RMV itself, while towing a sonar array, will be "flying blind" in littoral environments that are expected to… more
Abstract:DESCRIPTION (provided by applicant): Fungal infections have increased dramatically in recent years to become important causes of mortality in hospitalized patients. The increase in life-threatening fungal infections has brought about an increased use of antifungal drugs and a pressing need for new,… more
Abstract:OmniSite Biodiagnostics, Inc. and its parent company, Systems and Processes Engineering Corporation (SPEC), have extensive experience in both microfluidic, micromechanical (MEMS) and Fluorescence detection technologies. OmniSite proposes to design and prototype a compact, handheld and low power… more
Abstract:Coherent Logix, Incorporated (CLX) proposes to develop a radiation-hardened, highly efficient, parallel digital signal processor (PDSP) integrated circuit. For non-radiation-hardened applications, CLX is developing a new, revolutionary, highly-efficient, ultra low power signal processor based on… more
Abstract:Coherent Logix, Incorporated proposes to develop a Hyperspectral Image Processing Platform (HIPP) that will be able process 30 hyperspectral cubes per second, where a hypercube is approximately 100 MegaByte (MB) in size. The platform will be reprogrammable and dynamically reconfigurable to support… more
Abstract:Coherent Logix, Incorporated proposes to develop a Hyperspectral Image Processing Platform (HIPP) that will revolutionize hyperspectral image processing systems with the capability to process a 128 Megabyte (MB) hyperspectral data cube at more than 30 data cubes per second while simultaneously being… more
Abstract:72731-Thermoelectric power plants account for 39% of the fresh water withdrawn from streams and lakes in the United States, second only to agriculture. 3.3 billion gallons daily are lost to evaporation and 190 billion returned as warm water discharge. The link between adequate supplies of low-cost… more
Abstract:The use of fluid counter-jets to disrupt the axial symmetry of armor piercing shaped charge warhead jets was demonstrated during the last century, but the research was limited in its scope to large cross-sections. The mass and bulk of these cross-sections restricted their suitability for fielding… more
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