Abstract:DESCRIPTION (provided by applicant): Neurofibromatosis (NF) is an autosomal dominant disorder caused by mutations in the NF1 and NF2 genes. Currently, more than 100,000 Americans suffer from NF type 1 (NF1) which has one of the highest prevalence rates for a genetic disease (1/3,500 births). NF1 is… more
Abstract:DESCRIPTION (provided by applicant):
This Phase II proposal aims to simplify, expedite, and stabilize the recovery of high quality RNA from tissue samples. In Phase I, we demonstrated the feasibility of a hands-off, closed tube tissue disruption method termed "MELT" (Multi-Enzymatic Liquefaction… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of this proposal is to develop methods for the cost-effective, large-scale synthesis (up to kilograms amounts) of capped, polyadenylated RNA. Several companies are using capped RNA to produce human vaccines against cancers and infectious… more
Abstract:DESCRIPTION (provided by applicant): The long-term objectives of this proposal are to permit the isolation of RNA from fixed and imbedded tissues for gene expression analysis. The widespread use of tissue fixation and embedding in both clinical and research settings has resulted in the accumulation… more
Abstract:DESCRIPTION (provided by applicant): Accurate differentiation of fusion transcripts derived from chromosome translocations is of critical importance for optimizing treatment strategies for leukemia. However, as the number of leukemia associated translocations is steadily increasing, single-tube,… more
Abstract:DESCRIPTION (provided by applicant): Archives of formalin-fixed paraffin embedded (FFPE) human histological tissue samples, probably numbering in the millions of tissue blocks, constitute a tremendous, yet underutilized, historical resource for studying gene expression changes associated with human… more
Abstract:DESCRIPTION (provided by applicant): Small interfering RNA (siRNA) specifically degrades target complementary mRNAs in cells. The vector system that controls the expression of siRNAs has been widely used for academic research and clinical therapy. Although Pol III promoters are used to express small… more
Abstract:DESCRIPTION (provided by applicant): RNA molecules known as microRNA (miRNA) can influence the expression of target genes. It is thought that mammalian miRNA change the expression of their targets protein while leaving the expression of the cognate mRNA unmodified.
These non-protein-encoding… more
Abstract:In the Phase I SBIR effort, AMBP Tech developed a new film deposition technology, Pulsed Arc Molecular Beam Deposition (PAMBD). This new approach to depositing films offers substantial advantages over many existing deposition technologies. We propose to optimize and perfect this technology in a… more
Abstract:Directed Energy Weapons of the microwave nature require high microwave power devices which employ insulators. Currently, a major limitation to the microwave power that can be generated is the limited electric field an insulator can withstand within vacuum due to the surface flashover phenomena. … more
Abstract:Integral Wave Technologies (for known as Arkansas Microelectronic Development Corporation) is developing a process for growing ferroelectric, polycrystalline barium titanate (BaTiO3) thin-films, by anodic oxidation of co-evaporated barium-titanium films (BaTi). Though films of this nature find… more
Abstract:DESCRIPTION (provided by applicant): Current interbody fusion devices for lumbar fusion need improvement owing to lower than desireable success in fusion and difficulty in postoperative assessment effusion. A promising and novel approach for intervertebral fusion is to provide a cortico-cancellous… more
Abstract:This Phase II project is aimed at developing an advanced information fusion system applicable to the test and evaluation environment based on the development and applications of advanced concepts of intelligent processing to data fusion and analysis and decision support systems. The highly demanding… more
Abstract:The objective of this project is to demonstrate the feasibility of an innovative intelligent autonomous mission planner/controller for networked multiple manned/unmanned autonomous vehicles which is applicable to the Future Combat System (FCS), Future Force Warrior (FFW), and Future SOF systems. The… more
Abstract:The objective of this project is to investigate and demonstrate the feasibility of 4D GIS Based Virtual Reality for Moving Target Prediction. The proposed algorithms are based on the geographical information system (GIS) to provide a virtual scenario of moving targets prediction and possible hitting… more
Abstract:The objective of this project is to investigate, evaluate, and demonstrate the feasibility of an innovative Miniaturized Smart Self-calibration Electronic Pointing Device (EPD) for Indirect Fire Weapons applications using the coremicro Palm Navigator, as the mortars azimuth/heading and elevation… more
Abstract:The objective of this SBIR Phase I project is to develop and demonstrate a low cost, lightweight, miniaturized Integrated Collision Avoidance Enhanced GN&C System for Smart Air Vehicles. The proposed system takes advantage of the latest Commercial-Off-the-Shelf (COTS) components, American GNC… more
Abstract:The objective of this project is to investigate, evaluate, and demonstrate the feasibility of an innovative Integrated Communication and Wireless Wide Area Networked Precision Geolocation system for generic multi-agent high-performance real-time Combat Decision Aids System (CDAS) for Future Combat… more
Abstract:Distributed Reconfigurable Intelligent software agent technologies are key and revolutionary technologies that are needed to fulfill spacecraft autonomy and robustness operations capabilities and functions. The Distributed Reconfigurable Intelligent spacecraft autonomy and robustness system… more
Abstract:Recent events showing the willingness of terrorist organizations and rogue states to consider biological weapons of mass destruction have underscored the need for rapid means to identify these agents. In particular, first responders entering a scene where biological agents may have been dispersed… more
Abstract:The goal of the proposed FieldTrainer control system is to enable astronauts to teach Robonaut on-orbit how to perform new complex tasks using EVA tools. Employing a show-and-tell approach to robot training, the control system acquires rule-based task plans through verbal dialog between robot and… more
Abstract:75471S Measurement techniques are needed to validate technologies developed to enhance the net long-term sequestration of carbon in man-made and natural environments. In particular, a capability is required to determine increases in carbon fixation or sequestration of 1 tonne per hectare per year.… more
Abstract:This Phase I SBIR proposal is directed at the development of the design for a helicopter radar landing aid to assist the pilot in landing in brown out or white out conditions where the helicopter is engulfed in a cloud of sand or snow as it descends. The proposed down-looking, time modulated ultra… more
Abstract:DESCRIPTION (provided by applicant):
The overall objective of this proposal is to investigate the feasibility of the ruminant salivary gland as a system for the production of therapeutic human proteins. Protein therapeutics is currently in increased demand for the treatment of disease. Existing… more
Abstract:DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is a long-term, debilitating disorder that causes loss of memory and cognitive functions. There is an urgent need for effective therapeutic agents to ameliorate the symptoms of AD. Important molecular drug targets in AD are the… more
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