Abstract:The optimal design for a rapidly-deployable, airborne HAB identification sensor requires the determination of the minimum spectral, spatial, dynamic range, and deployment capabilities necessary to achieve the goal of operational detection. This sensor must be capable of rendering a positive… more
Abstract:DESCRIPTION (provided by applicant): Neurobehavioral assessments, including arousal activity level and sleep pattern, are endpoints of global nervous system function. Virtually all pathological conditions, particularly neuropsychological disorders such as anxiety and depression, and a variety of… more
Abstract:DESCRIPTION (provided by applicant): The querying of biological databases by biomedical researchers is hampered by the absence of metadata, which describe the "why" and "how" of the data generated by an experiment. Consequently, it is difficult for researchers to query for experiments stored in… more
Abstract:AFCO Systems Development proposes a PCI based system security monitor that combines an adaptable and update-capable platform with remote management and the capability to examine the host?s memory. The ability to scan the host memory is used to detect an infected computer whose operating system has… more
Abstract:Commercial and Military embedded systems are lacking security properties as demonstrated by the increase in system failures and service disruptions. These breaches are caused by the inability of the operating system to recognize and/or prevent intrusion by unauthorized agents. A family of reliable… more
Abstract:DESCRIPTION (provided by applicant): In this proposal, we present a novel approach for the identification and immobilization of a BMP mimetic. We plan to use phage display technology to identify peptides that mimic BMP-like signaling of the BMP receptors. These peptides will be linked to a… more
Abstract:Endosseous metallic implants are common alloplastic devices used in medicine and dentistry. The
orthopedic and dental marketplace continues to grow and indications for implants are expanding. There is a perceived need to improve both the successful healing (osseointegration) and the long term… more
Abstract:DESCRIPTION (provided by applicant): This Phase I SBIR application addresses the NIAID call for high priority biodefense products such as novel vaccines and therapeutics to protect our nation against various biothreat agents. Although these types of proposals do not require a significant amount of… more
Abstract:This proposal is fully responsive to DARPA topic SB052-012. It provides research toward an innovative non-intrusive health monitoring system for military personnel recovering from combat injuries. The proposed approach will collect and analyze real time data of vital signs, patient activity, fall… more
Abstract:Current methods used for the destruction of CW agents are cumbersome, require extensive capital equipment such as incinerators and water reactors and pose potential environmental problems themselves. A novel approach for the destruction of CW agents involves genetically engineering microorganisms… more
Abstract:Current technologies for marking of landing zones as well as areas for search and rescue have significant drawbacks ranging from the additional weight of batteries for some systems to plastic and metallic debris left behind. There are clear advantages both operationally and environmentally to… more
Abstract:In this Phase I, Agave BioSystems proposes to develop a catalytic organophosphorus bioscavenger based on human paraoxonase 1 (PON1) for the protection of personnel against OP nerve agents. A catalytic bioscavenger that detoxifies multiple organophosphorus (OP) molecules by hydrolysis rather than a… more
Abstract:Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. Understanding how the body repairs damaged tissue and what genes and biochemical factors influence the wound healing process will have tremendous impact on the treatment of chronic wounds… more
Abstract:Cultured cell-based biosensors offer insight into the physiological action of the agent of interest, which is an advantage over other types of sensors. The development of cell-based biosensors that are field-portable would increase their utility in toxicology and environmental monitoring. One of… more
Abstract:Biofilms are ubiquitous in the environment. Few surfaces resist biofilm formation, most promote it. Biofilm formation poses problems in water systems as they can clog pipes and pores, block filters, reduce heat transfer, and in general restrict flow. Their metabolic products can aid corrosion,… more
Abstract:A PCR based assay has been developed to detect Leishmania parasites, but PCR requires sophisticated laboratory instruments and trained personnel to interpret the data. The parasite can also be identified in infected sand flies by skillful dissection and microscopic examination but this is… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this research is to determine the efficacy of orally administered recombinant human lactoferrin (rhLF) in Phase II clinical trials in patients with mild to moderate asthma.
Asthma is one of the most prevalent chronic inflammatory diseases in the… more
Abstract:DESCRIPTION (provided by applicant): Tissue engineering, grafting procedures, regeneration, and tissue remodeling are developing therapies with great potential medical value. None of these therapeutic modalities are yet fully effective or predictable. Glycosaminoglycan-decorated proteoglycans such… more
Abstract:There are many products that can identify chemical weapons. They range in complexity from simple colorimetric chemical test strips or gas tubes, to more complex multi-step test kits, to intricate arrays of gas chromatographs and mass spectrometers. None of the products is specifically designed to… more
Abstract:DESCRIPTION (provided by applicant): Science apathy is growing at the K-12 education level, and represents an alarming development with potentially devastating consequences at individual, societal and economic levels. Surprisingly, this student apathy is increasing while the general public reads… more
Abstract:Agile has successfully demonstrated the ability to design and manufacture high performance, voltage controllable analog millimeter wave phase shifters for use in phased array antennas using the ferroelectric material, Barium Strontium Titanate (BST) in thin film form. Agile has also performed… more
Abstract:Agile has successfully demonstrated the ability to design and manufacture high performance, voltage controllable analog phase shifters for use in phased array antennas using the ferroelectric material, Barium Strontium Titanate (BST). Agile has also performed pioneering work in the design of phased… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will build a first-release Web-based system for content authoring and delivery that supports multiple approaches to pedagogical practice and provides efficient, easy to use methodologies with which course designers can employ system… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will study the feasibility of creating test construction tools that allow school educators to conveniently produce and deliver tests ranging from informal assessments of mastery that can be given and taken on the fly, to tests that… more
Abstract:Opportunities exist today to utilize proven robotics technology to automate the process of building air-launched ready service weapons aboard aircraft carriers and amphibious assault ships. Affordable and reliable automated systems, working in concert with crew members, promise means to increase… more
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