Abstract:DESCRIPTION (provided by applicant): Because of the potential bioterrorism threat, the development of safe and effective vaccines against the infectious microorganisms on the select agents list is a national and worldwide goal. In some cases there are vaccines in existence but… more
Abstract:… Blot, which utilizes lentil lectin glycoproteins isolated from parasites derived from infected pigs - currently the most sensitive and specific serological test for detection of antibodies against the larval stage of T. solium. Two types of tests will be developed: a… more
Abstract:DESCRIPTION (provided by applicant):
Our primary interest is to develop an imaging method based on bispecific antibody (bsMAb) pretargeting used in combination with F-18 labeled peptides. Such a method would improve the specificity for PET imaging based on the bsMAb's… more
Abstract:DESCRIPTION (provided by applicant): The objective of this work is to develop an antibody-drug conjugate that will be useful against B-cell malignancies that express the CD74 antigen. More specifically, the conjugate will be a doxorubicin derivative attached to the… more
Abstract:DESCRIPTION (provided by applicant): Emulsans are a novel family of functionalized polysaccharides that can be extensively modified structurally leading to substantive changes in solution properties (emulsification) and biological responses in vitro (i.e., macrophage activation… more
Abstract:Prostate cancer is the most commonly diagnosed form of cancer and the second leading cause of cancer-related death in males. A highly sensitive, selective, noninvasive screening assay is needed to diagnose prostate cancer and to monitor effectiveness of treatment or recurrence.… more
Abstract:DESCRIPTION (provided by applicant):
Early diagnosis and immunotherapeutic stimulation of a patient's own immune system to detect and destroy tumors is the best hope for the treatment, prevention and eventual cure for ovarian cancer. The overall goal of this proposal is to… more
Abstract:The goal of this proposal is to develop a new treatment for strabismus, a visual disorder affecting 3-4% of the population, using a novel technology that we have recently formulated. This involves specific targeting and elimination of cholinergic motor… more
Abstract:… an initial concept for autonomously detecting, classifying, and predicting damage in carbon-fiber-reinforced polymer (CFRP) composites using subtle changes in the resistivity signature of the structure. The demonstrated approach fused raw measurement and processed data from … more
Abstract:Impact Technologies, in cooperation with Pratt & Whitney and Qualtech Systems Inc., propose to develop and commercialize a simulation-based design application for dynamic failure mode and effects analysis (FMECA++) that specifically focuses on designing and verifying EHM… more
Abstract:… of the Three-Bearing Swiveled Module (3BSM) of the Joint Strike Fighter (JSF). On the Short Take-off and Vertical Landing (STOVL) variant of the JSF, the adjustable 3BSM at the rear of the engine redirects thrust downward to assist in STOVL maneuvers. The 3BSM is a dynamic… more
Abstract:Based on a series of successful Phase I demonstrations, Impact Technologies, in collaboration with the University of Dayton Research Institute (UDRI) and GE Aircraft Engines, propose to further develop and implement an autonomous system for detecting, localizing and predicting… more
Abstract:… and execution. The ACLM will comprise of two functional modules: Prognostic Health Management (PHM) and Adaptive Intelligent Control (AIC). During Phase I, Impact developed an architecture, along with prototype PHM and AIC algorithms, and demonstrated them on a generic jet… more
Abstract:… health state information, including operational history and detection of incipient faults, to accurate remaining useful life predictions at any point in the system's life cycle. The dominant failure modes of switching mode power supplies were identified by a Pareto… more
Abstract:… development of advanced drive train systems, traditional methods for estimating and tracking bearing health fall short in light of system complexities and the influence of highly dynamic, extreme operating conditions on the component. In Phase I, Impact developed a health… more
Abstract:…, proposes to develop and demonstrate an integrated, agent-based, self-evolving maintenance reasoning system that can effectively utilize PHM system data/information and support an autonomic logistics concept. The Impact/IAC team will develop and implement this concept as a… more
Abstract:… and lightweight health and usage monitoring system (HUMS) for unmanned aerial vehicles (UAVs). Based upon the requirements for UAV health monitoring investigated in Phase I, the Impact/Lord/Boeing team will re-design and mature the hardware/software concept, fabricate a… more
Abstract:Automated Contingency Management (ACM), or the ability to confidently and autonomously adapt to fault conditions with the goal of still achieving mission objectives, can be considered the ultimate technological goal of a health management system. In an innovative Phase I STTR… more
Abstract:… System. Shelf life of missiles is limited due to aging and damage to the solid propellants. This, in turn, is due to daily and annual variation in storage conditions, shocks, stresses and transportation induced vibrations. The Army and missile manufacturers have a wide range… more
Abstract:Impact Technologies, in collaboration with the Georgia Institute of Technology and support from various JSF system suppliers, propose to further develop and deploy an advanced, open-systems software application that provides a comprehensive resource for Verification and… more
Abstract:Impact Technologies proposes to develop a Matlab/SimulinkT based Probabilistic Modeling and Analysis Toolbox (P-MAT) application that provides an intuitive and information-rich modeling environment for probabilistic reliability analysis with a powerful toolset consisting of… more
Abstract:Impact Technologies, LLC, in collaboration with Pratt & Whitney and Pennsylvania State University proposes the development and validation of a software tool for the analysis of robustness and performance of integrated flight and propulsion control systems. This tool will enable… more
Abstract:Impact Technologies, LLC will lead an effort that will be supported by Standard Aero, San Antonio, Texas to formulate a methodology that will extend the current maintenance cost modeling tool to account for differing time since overhauls (TSO) and differing reliabilities of… more
Abstract:… monitored drive train components, such as gears and bearings, and reduce hardware complexity, signal processing and computational needs. These algorithms will be packaged as an embedded software module that can be fused with gear and bearing modules to provide a… more
Abstract:Impact Technologies, in collaboration with Rolls Royce Naval Marine (support letter attached) and Life Cycle Engineering (LCE), propose the development and demonstration of a shipboard and shore-based maintenance decision tool that can autonomously and optimally select and… more
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