Abstract:DESCRIPTION (provided by applicant): Influenza virus causes a pandemic disease of the respiratory tract that results in significant human morbidity and mortality. Diagnosis of influenza virus infection during the winter months makes up a large component of the clinical virology… more
Abstract:The goal of this proposal is find novel combinations of approved drugs for the treatment and/or prevention of infection with filoviruses. Ebola and Marburg viruses, the only filoviruses, cause an acute hemorrhagic fever syndrome which has a high mortality rate and poses … more
Abstract:… contributed to major discoveries. APS mega pixel arrays for fine granularity tracking have already demonstrated advantages over CCDs, such as optimized readout, reset, and digitization at pixel level. Nonetheless, their readout and digitization rate is still a limiting… more
Abstract:The objective of this research is to investigate the technical feasibility of building a bidirectional converter to achieve the power density, efficiency, and coolant temperature objectives using an innovative marriage of state-of-the-art technologies. These technologies each… more
Abstract:This Small Business Innovation Research (SBIR) Phase II research project will develop highly miniaturized power converters by developing a functional, scaled-down hardware prototype of a high-temperature multichip power module (MCPM). To achieve this goal,… more
Abstract:DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a commercial diagnostic for the early detection of age-related macular degeneration (ARMD). It relies on a functional test of dark adaptation kinetics (the transition from being light-adapted to… more
Abstract:The Atmospheric Pressure Plasma Jet (APPJr) technology invented at Los Alamos National Laboratory and exclusively licensed to APJeT, Inc., is a revolutionary platform technology enabling economic application of atmospheric pressure plasma technology in an array of applications.… more
Abstract:Global market demands for fresh tuna products have resulted in increased pressure on tuna fisheries worldwide. As a result, consumer driven market pressures have created significant commercial importance in the U.S. market for certain high-value tuna species. Domestic tuna… more
Abstract:…, sphingosine-1-phosphate (S1P) produced by SK mediates the effects of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and protein kinase C (PKC), all having critical roles in the manifestations of diabetic retinopathy. Therefore, SK is a… more
Abstract:… (S1P) produced by SK within luminal epithelial cells in response to TNFalpha is critical to the cascade of events that results in the recruitment and activation of neutrophils and mast cells that further escalate the inflammation process in IBDs. Therefore, SK is a key… more
Abstract:…, sphingosine-1-phosphate produced by SK mediates the effects of tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta), pro-inflammatory cytokines that are central to pathologic processes in this disease. In spite of accumulating evidence for a pivotal… more
Abstract:… with adverse side effects due to their lack of specificity against cancer cells. Therefore, there is an acute need for the development of more effective and tumor-specific therapies for the treatment and prevention of cancer.
Immunotherapy has recently gained impetus as a… more
Abstract:DESCRIPTION (provided by applicant): Acid-prepared mesoporous silica ("APMS") shows significant advances over commercially available silica in high performance liquid chromatography ("HPLC"), a technique commonly used to isolate molecules. HPLC columns containing APMS show… more
Abstract:…hic variance. The methods to be implemented in the proposed software will account for this uncertainty and incorporate it into the assessment of status and other outputs produced. Broader impacts of the project will include standardization of the monitoring process for a broad… more
Abstract:Efforts will focus on the physical and logical interface design for a bidirectional translation device. The deliverable will be a prototype design as well as recommendations on ergonomic factors and interaction requirements of a bidirectional speech driven mobile translation… more
Abstract:… pharmaceutical industry to help evaluate literally tens of thousands of test compounds in the search for modern therapeutic drugs. To achieve this, several research aims must be met. First, new manufacturing techniques must be implemented to produce ECIS arrays in a standard… more
Abstract:… its relatively low cost. The bleaching process uses large amounts of chlorinated and caustic chemicals to brighten raw pulp which is brown in color due to the presence of residual lignin. Depending on the bleaching chemicals used, the liquid waste stream may contain a number… more
Abstract:Joint Tactical Radio System (JTRS) is a software radio capable of tuning from 2MHz to 2000MHz. A wideband antenna or a set of antennas are needed to support operation across the entire frequency spectrum of JTRS. To meet this need, Applied EM is proposing an… more
Abstract:Current anti Jam GPS antennas are approximately 14" in diameter making them too large for several platforms of interest such as unmanned aerial vehicles, missiles and fighter aircrafts. A modified version of this antenna array is significantly smaller in size (seven inch… more
Abstract:Providing accurate PVT (Position, Velocity and Time) information is very critical for systems like Joint Precision Approach and Landing System (JPALS). JPALS is a key component enabling U.S. military forces to be highly mobile and capable of "rapid response" on a global basis to… more
Abstract:… relates to antenna size and the other pertains to performance limitation imposed by antenna electronics implementations. The current antenna array GAS-1 CRPA has seven antenna elements and extends 14in diameter, making it too large for airborne platforms of interest. A… more
Abstract:… been achieved during the EH-60 QuickFix program. During this effort, Applied EM is proposing to develop very accurate modeling tools to predict performance of DF systems on rotorcrafts. DF arrays are normally designed without accounting for platform effects. When mounted on a… more
Abstract:This proposal is submitted under the Innovative Tools and Techniques Supporting the Practical Uses of Earth Science Observations topic. We seek to evaluate and demonstrate technical approaches for linking remote sensing rangeland products with a soil biogeochemical model to form… more
Abstract:… Thermal Control Material Systems (TCMS) an adhesives based on the next generation nano-cluster chemistry based new binder systems, through the systematic investigations to tailor required unique performance properties with reliability and durability. The efforts address a… more
Abstract:… zeolites were studied at AMSENG and MPL. MPL's efforts are in the areas of thin oxide films and towards the modification of one of the MBE unit to simulate spacecraft charging. These studies are the basis of the proposed efforts. Thus, the AMSENG-MPL team is in a unique… more
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