Abstract:This Small Business Innovation Research Phase I project will develop a fast-neutron detector capable of higher resolution and efficiency than previous detectors. Because fast neutrons are highly penetrating, they have the possibility of imaging and interrogating large, high-density objects.… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop a commercial neutron source for the treatment of brain and liver cancer based on boron neutron capture therapy (BNCT). Boron-containing compounds are injected into a patient's bloodstream and accumulate in a malignant tumor. When irradiated… more
Abstract:DESCRIPTION (provided by applicant): This is a Phase II SBIR proposal to develop a new therapy for the treatment of asthma. The desired outcome will be the identification of a therapeutic candidate to replace theophylline, a non-selective adenosine receptor antagonist that is effective in treating… more
Abstract:Endotoxemia (Sepsis) affects horses of all breeds and ages and is the leading causes of death in adult horses and foals. Consequently, its economic impact on the equine industry in the United States is devastating. This project seeks to develop new treatments for this disease.
Abstract:DESCRIPTION (provided by applicant): This is a phase I STTR application to study the efficacy of selective adenosine A2A receptor (A2AR) agonists developed in the laboratories of Adenosine Therapeutics (ATL) in models of Gram-positive bacterial sepsis which will be conducted in the University of… more
Abstract:An aqueous-based finish (sizing) was developed in Phase I to improve the carbon/vinyl ester interfacial bond. The finish is composed of a reactive coupling agent, a low viscosity vinyl ester resin, a free radical inhibitor, and a surfactant. The reactive finishes substantially improved the… more
Abstract:New high-temperature sizings are needed to improve the properties and durability of carbon/polyimide composites. Compatibility with weaving and braiding operations and improved wetting during prepregging or resin infusing polyimide resin is also needed. Achieving these characteristics will result… more
Abstract:High-temperature (HT) polymer matrix composites (PMCs) are desired for many aerospace and military applications. Silicon carbide (SiC) fibers provide a potentially attractive reinforcement for HT PMCs for applications ranging from propulsion systems to structures for the orbiting space plane. The… more
Abstract:Phase I results showed that two surface treatments, oxidative plasma and reactive finishes, are effective means of modifying the surface chemistry of exfoliated graphite nanoflakes. The surface modifications provide a more compatible surface energy for dispersion in polymers and create well-bonded… more
Abstract:NASA has numerous requirements for in-space repair capabilities to aid future missions beyond earth orbit. A subset of these requirements is adhesive patch materials that provide permanent or temporary repair of a wide variety of surfaces with minimal surface preparation. Prior work on light (UV… more
Abstract:The Navy intends to start using a significant quantity of composite structures in surface ship construction in an effort to decrease costs as well as to reduce the visibility of the ships to radar. The large size of the target structures necessitates the use of low temperature, non-autoclave… more
Abstract:The recycling of composites on a large scale is an unsolved problem. Currently, the material is either ground up into near-worthless fillers, incinerated, or digested using environmentally questionable technology. Adherent Technologies, Inc. has developed a number of technologies to reclaim… more
Abstract:The future generation of both military and commercial diesel engines will operate at significantly higher temperatures and pressures than today's engines. The future combat system diesel engine operating parameters demand significant design improvement of power cylinder insulation. Increased… more
Abstract:A high-power density, Low Heat Rejection (LHR) diesel engine design for both traditional and hybrid Future Combat System (FCS) vehicle configurations is being proposed. Work under this proposal includes application of LHR engine technology to improve power density and life cycle durability of a… more
Abstract:We propose to develop a novel source of THz radiation based on monolithic integration of dual wavelength Quantum cascade laser (QCL) and intersubband difference frequency generator (DFG) with Cerenkov phase-matching. In addition we propose to demonstrate a novel 3-frequency coherent heterodyning… more
Abstract:The objective of this project is to develop a multi-purpose combination type optical fiber sensor that enables simultaneous sensing of microstructural evolutions in the sensor materials and the environmental conditions such as pressure and temperature. It is very well known that materials subjected… more
Abstract:Terrorists can employ small water craft, boats, submersibles and swimmers to detonate explosives along side ships, or attach devices to the hull above or below the waterline. Ship defense against "asymmetrical threat" targets such as multiple small boats in the complex littoral environment are made… more
Abstract:The Army's Future Combat System will rely on a data communications backbone based on the tactical mobile ad-hoc communications network (TMACN). The unique nature of TMACNs - their mobility, adaptability, and potentially substantial sizes - makes performance prediction a difficult task, and one that… more
Abstract:Protection of ground troops and physical assets against hostile attacks on the battlefield is a crucial capability that must be provided by a combination of sensors and automated signal processing software that can function at all times, including in low-light/no-light and non-line-of-sight… more
Abstract:High-frequency acoustic modems are required to provide undersea communication networks to support covert surveillance operations. These modems can also be used as platforms for compact, low power surveillance sensors and processing. A natural first step would be to integrate a capability for passive… more
Abstract:The successful execution of the current high-capacity optical-networking environment, which supports supercomputing centers at the DOE national laboratories, requires adpative and finer-grained management/set-up of necessary bandwidth and low-delay paths between distributed applications. Whereas… more
Abstract:DESCRIPTION (provided by applicant): Obstructive Sleep Apnea (OSA) is the most common disorder observed in the practice of sleep medicine and is responsible for more mortality and morbidity than any other sleep disorder. OSA causes daytime drowsiness, and has been associated with hypertension,… more
Abstract:DESCRIPTION (provided by applicant): Obstructive Sleep Apnea (OSA), a highly prevalent, under-diagnosed condition is responsible for more mortality and morbidity than any other sleep disorder and has been identified as a major public health concern. Pediatric OSA is also widespread with an estimated… more
Abstract:DESCRIPTION (provided by applicant): The detection and enumeration of circulating tumor cells (CTC) has the potential to become a very powerful tool in cancer diagnosis and treatment. However, current technologies for CTC detection are not yet established in routine clinical practice. One primary… more
Abstract:DESCRIPTION (provided by applicant): The ability to culture human embryonic stem cells generated a great deal of excitement about their vast potential for treating a variety of human diseases such as diabetes, heart disease, neurological, retinal and skin disorders to name a few. Unlike adult stem… more
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