Abstract:In order to implement effective, safe, and scientifically-based approaches to the remediation of contaminated sites, such as some in the DOE complex, engineers and policy makers require fundamental information on microorganisms in the subsurface. In particular, information is needed to identify: … more
Abstract:This Small Business Innovative Research (SBIR) Phase I project aims to integrate microfluidc sample preparation and a gel-drop microarray detection technology clinical diagnostic use. The end user will be able to perform testing for the presence of infectious disease and results within 30 minutes.… more
Abstract:DESCRIPTION (provided by applicant): Whether in clinical or epidemiological settings, there is a continued need in identification of B. anthracis and unambiguous discrimination it from close relatives and organisms with similar characteristics. Genomic analysis provides direct information about… more
Abstract:Commercially available products rich in phytosterol may now be used to cut serum low-density lipoprotein by as much as 14 percent. Unfortunately, phytosterols are poorly soluble and therefore present unique problems concerning their ability to suppress cholesterol absorption in the gut. This… more
Abstract:DESCRIPTION (provided by applicant): Aktiv-Dry LLC, in collaboration with Nabi Biopharmaceuticals, proposes to develop and evaluate in animal models the needle-free respiratory delivery of fine dry powder nicotine vaccine. While syringe and needle have been a common vaccine administration mechanism,… more
Abstract:Currently the E-2C is covered with antennas for VHF/UHF line of sight, UHF satellite communications, L-band and GPS functions. There is a need to condense some of these functions into a single aperture to free up real estate on the aircraft for future additions and cut down on interference between… more
Abstract:Alaska Native Technologies, LLC proposes to develop a Near-Field Acoustic Holographic Calibration System that would be integrated into a wave piercing Bow Sonar to provide in-port calibration capability for a vessel.
Abstract:DESCRIPTION (provided by applicant): The trigger for autoimmune destruction of pancreatic beta cells in Type 1 diabetes (T1D) is unclear. Evidence exists for the role of increased intestinal permeability, secondary to intestinal tight junctions (tj) disassembly, in the pathogenesis of various… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will research and develop a maskless lithography tool based on the results of the feasibility study. The company has a unique and proprietary approach to achieve higher throughput and lower cost than currently available maskless… more
Abstract:The ultimate goal for near-eye displays is visual acuity-limited resolution across a wide field of view. Alces Technology has a novel light engine, capable of better than 3k x 6k resolutions without tiling, yet maintaining the temporal qualities necessary for fast-jet simulations. This light engine… more
Abstract:This Small Business Technology Transfer Research (STTR) Phase II project provides for the commercialization of surface-passivated composite titania/zinc oxide particles for benign protection from UVA and UVB radiation. The composite particles are manufactured via novel atomic layer deposition (ALD)… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project supports the development of ultra-fast (< 1 ns) response Transient Voltage Surge Suppression (TVSS) devices to protect the power infrastructure. Fine nickel particle (~ 50-150 micrometer) samples will be nano-coated by Atomic Layer… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project will demonstrate a new nano-scale, conformal, atomic layer deposition (ALD)-enabled hermetic capping. Such an innovative capping technology will transform MEMS and electronics integration from dual-in-line packages (DIP) into chip-scale… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project provides for the commercialization of composite alumina/tungsten/alumina (Al2O3/W/Al2O3) trilayers deposited by Atomic Layer Deposition (ALD) on carbon nanotubes (CNTs) to form coaxial nanowires/nanocables for nanoelectronic applications… more
Abstract:DESCRIPTION (provided by applicant): Advances in radiopharmaceutical have dramatically escalated the use of intraoperative gamma probes in surgery. Such probes provide benefits of increased tissue specificity obtained for biopsy, minimally accessed incisions, and the reduction of inpatient hospital… more
Abstract:DESCRIPTION (provided by applicant): Early detection and routine clinical screening represent the first line of defense for managing cancer, a disease that claimed over 570,280 lives in the U.S. during the year 2005. Significant advances have been made in the medical imaging of tumors; however, many… more
Abstract:DESCRIPTION (provided by applicant): Radiation Monitoring Devices, Inc. (RMD) proposes to develop a field-portable instrument for the detection and identification of pathogenic viruses that are collected by an aerosol concentrator. It will incorporate modular, microfluidic platforms designed to… more
Abstract:Scintillation detectors, consisting of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of medical imaging applications such as positron emission tomography (PET). Yet, the performance of these systems is limited by the properties of the currently… more
Abstract:This Small Business Innovation Research (SBIR) Phase II research project aims to produce a radiation detector technology that will be able to provide a completely new level of performance for demanding industrial applications. Three different scintillator materials - LaBr3, LaCl3 and CeBr3 - have… more
Abstract:Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of nuclear weapons has reached a state of heightened urgency in recent years, especially since the events on September 11, 2001 and its aftermath. Gamma ray… more
Abstract:New technology is needed for the nondestructive inspection (NDI) of microscopic defects in the thin-wall, titanium alloy hydraulic lines used on aircraft. Once mounted on an aircraft, these tubes are difficult to access externally, making inspection of the tube from the inside the most practical… more
Abstract:Scintillation spectrometers, which consist of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of nuclear and elementary particle physics experiments. However, the performance of the detection systems used in these experiments is often limited by the… more
Abstract:Although inorganic scintillators are one of the most common detectors used in nuclear and particle physics experiments, the properties of currently available scintillator materials limit the performance and increase the cost of these systems. This project will develop a new class of scintillation… more
Abstract:New technology is needed for the nondestructive evaluation (NDE) of defects in gas turbine engines. While these defects adversely affect hot-section performance and reduce component life, they are difficult to detect and characterize without destructive inspection. The lack of detailed flaw… more
Abstract:Stereochemistry is an essential element of our organic life. Only certain enantiomers are useful as drugs for the human body. Raman Optical Activity (ROA) and vibrational circular dichroism (VCD) provide stereochemical information down to bond levels. Many biomolecules like proteins and DNA can… more
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