Abstract:The high penetration power of X-rays permit imaging through smoke, fire and metal, and enables precise recording of a test event under the harshest conditions. The advent of high flux flash x-ray systems has enabled a unique method of imaging very fast events on a 20 to 50 nanosecond scale that… more
Abstract:RMD proposes to develop a MEMS based complete blood count (CBC) instrument that can be used aboard a spacecraft. We will produce a microfluidic scale combination cell counter-flow cytometer for CBC analyses that can be communicated to ground bases by telemetry. The blood analyzer will utilize… more
Abstract:Gamma-ray spectrometers consisting of inorganic scintillators coupled to optical detectors such as photomultiplier tubes (PMTs) are an important element of the systems that are used to monitor and prevent the spread of special nuclear materials. Two very important requirements for the scintillation… more
Abstract:Maintaining the health of astronauts during extended spaceflight is critical to the success of the mission. Radiation Monitoring Devices, Inc. (RMD) proposes an instrument to monitor astronauts' physiological responses to stress, microgravity, radiation, infection, and pharmaceutical agents through… more
Abstract:Navy program office is seeking capability to monitor known pollutants in shipyard waste water discharges to comply with local environmental discharge limits. The pollutants of concern are heavy metal ions but petroleum hydrocarbons and semi volatile organics are also of interest. The monitoring… more
Abstract:U.S. forces working in low-level radiation environments have unsatisfactory choices for monitoring radiation exposure. A solid-state photomultiplier (SSPM) uses an array of silicon based avalanche photodiodes (APD) to collect light and produce a signal proportional to the amount of light collected.… more
Abstract:Proliferation of weapons of mass destruction, such as nuclear weapons, is a serious threat in the world today. Although gamma-ray detectors are an important component of systems used to prevent nuclear proliferation, the performance of such systems is currently limited by the characteristics of… more
Abstract:Radioactive materials are used in commercially important analytical instruments because of the ability of ionizing radiation to excite characteristic x-ray fluorescence lines. Radiation sources are often the most practical method for portable instruments, such as analyzers for lead paint in homes.… more
Abstract:The analysis and control of single macromolecules is an important goal of the DOE¿s Genome-to-Life Program. However, single molecule assays that use fluorescent dyes are not photostable, have low quantum yield, and have broad emission spectra. Conventional, confocal, fluorescence correlation… more
Abstract:Many facilities throughout the DOE Complex will reside in a safe storage, or surveillance and maintenance mode, until such time that funding resources are available to perform decontamination and demolition. Therefore, long-term monitoring systems are required to ensure against a contaminant… more
Abstract:DESCRIPTION (provided by applicant): Positron emission tomography (PET) of small animals is emerging as a very powerful tool for advancing our understanding of human diseases such as heart disease and cancer. Due to the small (sub-millimeter) feature sizes, dedicated, high resolution PET systems are… more
Abstract:DESCRIPTION (provided by applicant): RMD Inc. proposes to develop direct reading, highly sensitive, reusable point sensors for detecting organophosphate and carbomate pesticide and nerve agent contamination in liquid and air. The sensors can be made for visual detection and handheld instrument… more
Abstract:DESCRIPTION (provided by applicant): Although CsI:TI is one of the most desirable scintillators for a broad range of medical and industrial diagnostics, it has never been applicable to X-ray computerized tomography (CT). Despite the otherwise superb properties of CsI, it suffers from a persistent… more
Abstract:DESCRIPTION (provided by applicant): Nuclear medicine imaging modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) are powerful, non-invasive medical imaging techniques that provide an image of the three dimensional distribution of a… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a fast high spatial resolution scintillator for time-resolved neutron crystallography. Neutron crystallography compliments x-ray crystallography in its ability to precisely locate hydrogen atoms in protein molecules.… more
Abstract:DESCRIPTION (provided by applicant): The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the use of… more
Abstract:With the ever-increasing number of human disease models, particularly in smaller animals, high-resolution, emission/transmission tomography techniques have become extremely important. The main barriers to using existing modalities in studies of laboratory animals have traditionally been poor… more
Abstract:Nuclear medicine techniques such as Positron Emission Tomography and Single Photon Emission Computed Tomography have become powerful new tools in imaging biological processes in small laboratory animals. However, the performance of these systems is often limited by the properties of the detectors… more
Abstract:DESCRIPTION (provided by applicant): There is a considerable interest in using laser-manufacturing methods for medical applications due to their potential to reduce cost. In fact, the precision and low-force signature of lasers makes them very attractive alternatives to traditional machining methods… more
Abstract:X-ray detectors with high resolution, high sensitivity, and high count-rate are required for the electron beam systems used for materials science research at DOE facilities. In many studies conducted with electron beam systems, the characteristics of available X-ray detectors limit the system… more
Abstract:Advanced Photon Sources have proven to be outstanding facilities for x-ray diffraction and scattering of non-crystalline biological materials. The biggest problem is finding a detector that can provide multiple frames of detailed structural information, with the required millisecond time scales and… more
Abstract:Neutron crystallography compliments x-ray crystallography in its ability to precisely locate hydrogen and light atoms in various materials. This information is important for biological applications (for example, monitoring protein dynamics), and material research and security applications (for… more
Abstract:Optical detectors are a very important component of both existing and future particle physics experiments, including those being developed for dark matter studies. However, for dark matter studies, the expected performance of experimental systems is limited by the properties of presently available… more
Abstract:The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the use of targeted radiolabeled probes. … more
Abstract:DESCRIPTION (provided by applicant): Nuclear medicine techniques such as SPECT and PET are powerful tools for functional imaging of biological processes in vivo. Recently, there have been significant advances in development of human disease models in small animals. A critical advantage of SPECT and… more
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