Abstract:This Small Business Innovation Research (SBIR) Phase I research project will demonstrate the feasibility of direct detection and quantification of p53 antibodies as a model for other macromolecules in biological fluids without using any reporter molecules through the use of bio-sensing elements in a… more
Abstract:DESCRIPTION (provided by applicant): The presence of toxic chemicals and bioaerosols in households, workplaces and congregate living areas present a threat to human health. The capability of local surveillance of these toxicants can prevent the onset of hazardous conditions. The overall objective of… more
Abstract:Altex Technologies Corporation, a small business, and Pennsylvania State University, a research institution, have teamed up to develop the innovative Person Portable JP-8 Fueled Fuel Cell Power Generator (PJF-Gen). The 500-1000 watts system will be lightweight, the size of a lunch box, will… more
Abstract:Low temperature Solid Oxide Fuel Cells (SOFC), operating on JP-8 and other distillate fuels, are the ideal power sources for all applications, especially for portable power applications. By operating at lower temperature (400-600C) these systems have faster response, quicker startup, better… more
Abstract:Animal wastes are a n environmental problem, particularly in fee lot areas were animals are concentrated. If the wastes could be upgraded to a fuel by gasification and then burned inefficient small-scale engines, high value electric power and process heat could be produced, while mitigating… more
Abstract:There are over 480,000 trucks on the US roads, and each vehicle produces up to 20 tons CO2, 420 lbs of CO and 250 lbs of nitrous oxides per year, while idling to produce auxiliary power needed for the driver¿s comfort. A Quiet Reliable and Compact Fuel Cell Base APU (QRCFC-APU) is proposed to… more
Abstract:DESCRIPTION (provided by applicant): Proposed here is the development and application of a high-throughput, multiplexed PCR-based approach to gene expression analysis to broadly enable the use of gene expression profiling for drug research, development and high content screening. The proposed… more
Abstract:DESCRIPTION (provided by applicant): There is an urgent need to develop novel, cost-effective manufacturing processes to produce therapeutic antibodies commercially in order to reduce the high manufacturing expenses as well as to address the potential for limited manufacturing capacity. The… more
Abstract:DESCRIPTION (provided by applicant): The objective of this project is to develop an anti-tissue factor antibody, Sunol-cH36, as a treatment for Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). The association between coagulation and inflammation has been well established and… more
Abstract:The objectives of this research are to enhance and accelerate the in situ bioconversion of sequestered carbon dioxide, a greenhouse gas, into methane in the presence of hydrogen-rich coal macerals and paraffin. Methanogens require a source of hydrogen and an electron acceptor such as carbon dioxide… more
Abstract:In order to increase proton energy up to 8 GeV in a driver linear accelerator, particles must be accelerated through various stages and three different power levels (25kW, 100 kW, and 210kw). Unfortunately, no power coupler element for these cavities has ever been produced using U.S. industrial… more
Abstract:There are increasing demands to use high-beam-current, high-radio-frequency (RF) power, S-band cavities in existing and newly planned accelerator projects, in order to produce a very brilliant, broadband, coherent teraherz synchrotron radiation source (or for other purposes). For optimum… more
Abstract:Through the proposed USDA-SBIR Phase I Marketing and Trade project, market expansion and diversification opportunities will be explored for the Amazing Grains Grower Cooperative and their trademarked MontinaTM products. MontinaTM products are formulated from the gluten-free grain Indian ricegrass.… more
Abstract:ESCRIPTION (provided by applicant): Breast cancer is the most common malignancy which occurs in women and the second leading cause of cancer death. While the majority of breast cancers are sporadic (e.g. not inherited), approximately 10% are due to inherited mutations in the BRCA1 and BRCA2 genes… more
Abstract:DESCRIPTION (provided by applicant): Protein expression profiling is becoming one of the most attractive tools for monitoring the course of neoplastic disease as well as identifying diagnostic biomarkers associated with the disease. While several proteomic tools have been extensively investigated… more
Abstract:DESCRIPTION (provided by applicant): Research animals play a crucial role in biomedical research, drug development and toxicology testing. It is estimated that an average population of over 30 million mice and rats is maintained in the U.S. alone for these purposes. The presence of undetected… more
Abstract:DESCRIPTION (provided by applicant): Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United States. Considerable evidence has shown that cancer fatalities can be dramatically reduced through early detection and removal of premalignant adenomatous polyps by… more
Abstract:DESCRIPTION (provided by applicant): There exists an urgent need to develop an effective, non-invasive method for large-scale colorectal cancer (CRC) screening, the second leading cause of cancer deaths in the U.S. Such non-invasive testing, if instituted for a large segment of the population, could… more
Abstract:To support its use of MEMS sensors for vehicle health monitoring, the Air Force seeks to couple the harvesting of ambient energy sources with a micro energy storage device. Microbatteries have demonstrated their viability as a high density power source, but their short operating life limits their… more
Abstract:DESCRIPTION (provided by applicant): MicroRNAs (miRNAs) are a significant new class of biomolecules with potential to enhance human health. In the last three years, miRNA publications have increased exponentially as researchers have discovered the potential importance of these small RNAs in human… more
Abstract:DESCRIPTION (provided by applicant): Leukemia is a set of blood cancer characterized by the uncontrolled growth of developing white blood cells. The accumulation of cancerous cells interferes with the body's production of healthy blood cells therefore impairing immune response to infection.… more
Abstract:DESCRIPTION (provided by applicant): The overall objective for our proposed research is to use the emerging field of miRNA research to identify therapeutic targets for acute myeloid leukemia (AML), a genetically and phenotypically heterogeneous disorder of the hematopoietic stem cells that is… more
Abstract:DESCRIPTION (provided by applicant): Cervical cancer, caused by human papillomaviruses (HPVs), is a major public health problem, worldwide. About 230,000 women die of cervical cancer every year, the majority in developing countries. Although early detection via routine cytological screenings (Pap… more
Abstract:DESCRIPTION (provided by applicant): Tissue microarray (TMA) techniques involve arraying cylindrical tissue cores from different specimens on a single slide. TMA's are widely used to identify mRNA or protein markers in human diseases to provide valuable information for the mechanisms of human… more
Abstract:DESCRIPTION (provided by applicant): During Phase I of our proposed research, we will develop and validate procedures for recovering, labeling, and analyzing miRNAs from fixed tissue samples. The procedures will be based on the miRNA microarray and fixed tissue RNA isolation systems that we… more
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