Abstract:We propose to continue the development and characterization of a polymeric nanoencapsulation technology that can increase the lifetime of a protein therapeutic agent within a biological system. The materials have been demonstrated to exhibit no cytotoxicity and to efficiently deliver antibody… more
Abstract:We propose that a comparative colorimetric assay be developed that will use a ticket of the same dimensions as the current ANP immunoassay tickets. This will allow the AChE test to be conducted using a similar workflow as the lateral flow immunoassay-based HHAs and be similarly read on the ANP… more
Abstract:ANP Technologies proposes to develop a sample concentration system that uses commercial hollow fiber filtration technology with permanent anti-fouling coatings to concentrate biological contaminants in water sources or supplies to a level high enough to be readily detected. The filter technology… more
Abstract:As the global economic competition for qualified workforce increases, our country¿s ability to compete effectively in the global marketplace depends on our school systems¿ ability to create a competitive workforce. Recently, there has been an increase in expectation on American schools to perform… more
Abstract:Electricity generation accounts for greater than 50% of total U.S. farm emissions. Renewable energy sources such as wind and solar power are expensive and unreliable. The fuel costs incurred by U.S. farms are offset by supplemental assistance from the government. Particularly attractive are… more
Abstract:Military environments, specifically counter-terrorism and special operations, are characterized by individual and team decision makers who may be spatially (line of sight) separated and must coordinate to share information and resources to attain mission goals in dynamic and uncertain situations. … more
Abstract:DESCRIPTION (provided by applicant): This project is part of a long-term effort to reduce the burdens and disability associated with Autism Spectrum Disorders (ASD). The majority of adults and adolescents who have an ASD diagnosis do not have mental retardation, and are notable for their language… more
Abstract:DESCRIPTION (provided by applicant): There is a need for clinically-relevant imageable animal models of tumor blood flow, intravascular cancer-cell trafficking and extravasation, critical targets for current drug evaluation and development. Most models of tumor cell trafficking and blood flow are… more
Abstract:DESCRIPTION (provided by applicant): This Phase II application will further develop dual-color imageable tumor-host-interaction nude mouse models, developed in the Phase I application, to be used in Phase III to discover and evaluate new effective agents for stromal therapy, including angiogenesis.… more
Abstract:DESCRIPTION (provided by applicant): The facile availability of pluripotent adult stem cells would have many important therapeutic applications. Our recent results suggest that the hair follicle is a promising source for such stem cells. Our discovery that the neural stem cell marker nestin is… more
Abstract:DESCRIPTION (provided by applicant): The goal of this application is to develop imageable tumor-targeting bacteria that can cure tumors without progressive infection of the host. Previous experiments employed anaerobic microorganisms for cancer therapy but used a markedly different approach.… more
Abstract:Portable devices that can generate electricity from solar power are very attractive for many defense applications, in particular for mobile defence units. Light and durable solar cell panels would greatly simplify the logistics of military operations, such as by eliminating heavy and cumbersome… more
Abstract:As the important role of NASA "missions to earth" has been clearly demonstrated in recent years, the need for radar antenna systems that have large fields of coverage has gained increased emphasis. In order to achieve the desired performance from space, the antenna systems must have surface areas… more
Abstract:Reconfigurable antennas are attractive for remote sensing, surveillance and communications, since they enable changes in operating frequency and / or radiation pattern, resulting in high-bandwidth antenna systems, with broad areas of coverage. Additional functionality would be achieved by… more
Abstract:Reliable and efficient sources of energy are of critical importance for space exploration. Solar power has long been recognized as one of the most promising sources of energy for space missions since it represents one of the few renewable energy sources in space. Advances in amorphous silicon… more
Abstract:To accurately model dispensing events in conceptual AF and Navy dispensing munitions, the simulation framework used to build the simulations must incorporate fast, accurate, scalable physics engine algorithms as well as robust interacting aerodynamic flow estimation. The Phase I SBIR effort… more
Abstract:The objective of this proposal is to demonstrate the feasibility of a process for producing ultra-high conversion efficiency (37-41%) AM0 multijunction solar cells from dislocation-free non-lattice matched heterostructures using a proprietary wafer bonding / layer transfer process. The overall cell… more
Abstract:We propose to design a compact, rugged and low-power optical system for use in rubidium Bose-Einstein condensate (BEC) systems and to validate critical design features. AOSense previously has designed and fabricated atom-optic (AO) sensor laser systems and control electronics for a variety of… more
Abstract:The goal of this proposal is to find novel combinations of approved drugs for the treatment and/or prevention of infection with filoviruses. Ebola and Marburg viruses, the only filoviruses, cause an acute hemorrhagic fever syndrome which has a high mortality rate and poses a significant… more
Abstract:DESCRIPTION (provided by applicant): We will develop a disposable, affinity-based capillary tube [AffiTip] that is capable of removing 99% of the interfering bulk protein from < 5 :L of undiluted plasma within 2 minutes for use prior to analysis for biomarkers [specific compounds that link mechanism… more
Abstract:Many NASA space and Earth programs in the infrared range 1060-1550 nm are limited by the detector performance that require long exposure time due to their low sensitivity and/or high noise. Efficient, single-photon counting in the infrared providing short exposure time and large area for increased… more
Abstract:The inherent limitations relating to power density, conversion efficiency, and thermal tolerance establish barriers to future development in key military, automotive, and aerospace applications. This research aims to overcome these limitations and develop an unprecedented compact, high power, high… more
Abstract:The purpose of the Power Generating Backpack is to allow soldiers to generate electricity while walking. This backpack represents an alternative to bulky battery systems soldiers often carry on the battlefield. The adoption of this backpack will result in a lighter load, thus improved comfort and… more
Abstract:DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a polymer stentgraft for the treatment of cerebral aneurysms. The stentgraft is formed from coaxial inner and outer tubes of elastomeric polymer, with the gap between the tubes filled by an uncured liquid adhesive. The… more
Abstract:This proposal offers an approach to integrate the latest corrosion sensor technology with corrosion structural effects modeling to enable the transition from periodic corrosion inspections to an efficient, focused prognostics and health monitoring (PHM) system. The fundamental vision of the… more
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