Abstract:DESCRIPTION (provided by applicant): We will develop a disposable, affinity-based capillary tube [AffiTip] that is capable of removing 99% of the interfering bulk protein from < 5 :L of undiluted plasma within 2 minutes for use prior to analysis for biomarkers [specific compounds that link mechanism… more
Abstract:Many NASA space and Earth programs in the infrared range 1060-1550 nm are limited by the detector performance that require long exposure time due to their low sensitivity and/or high noise. Efficient, single-photon counting in the infrared providing short exposure time and large area for increased… more
Abstract:The inherent limitations relating to power density, conversion efficiency, and thermal tolerance establish barriers to future development in key military, automotive, and aerospace applications. This research aims to overcome these limitations and develop an unprecedented compact, high power, high… more
Abstract:The purpose of the Power Generating Backpack is to allow soldiers to generate electricity while walking. This backpack represents an alternative to bulky battery systems soldiers often carry on the battlefield. The adoption of this backpack will result in a lighter load, thus improved comfort and… more
Abstract:DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a polymer stentgraft for the treatment of cerebral aneurysms. The stentgraft is formed from coaxial inner and outer tubes of elastomeric polymer, with the gap between the tubes filled by an uncured liquid adhesive. The… more
Abstract:This proposal offers an approach to integrate the latest corrosion sensor technology with corrosion structural effects modeling to enable the transition from periodic corrosion inspections to an efficient, focused prognostics and health monitoring (PHM) system. The fundamental vision of the… more
Abstract:DESCRIPTION (provided by applicant): In developed countries, approximately 1:1000 children are born deaf and approximately 1:300 children are born with some lesser degree of hearing loss. At least 50% of the deafness and hearing impairment is likely to be attributable to genetic factors, with a… more
Abstract:DESCRIPTION (provided by applicant): The goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism, we have focused on SK as an innovative molecular target for the development… more
Abstract:DESCRIPTION (provided by applicant): Principal Investigator/Program Director: French, Kevin J. Abstract: The long-term goal of this program is to develop inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism, we… more
Abstract:Commercially available sorbents for controlling mercury emissions from coal-fired utility boilers are affected detrimentally by the presence of SO2 and SO3 in the gas stream. These contaminants present a significant challenge to a large portion of utility boilers, which will need to meet upcoming… more
Abstract:DESCRIPTION (provided by applicant): We have shown that Fas ligand (FasL) gene therapy induces protective immune responses in rodent models. Yet, despite these unquestioned benefits to study mechanistic questions, various factors preclude precise extrapolation of safety data from rodent gene therapy… more
Abstract:This innovation is a low mass, low volume, gas based system that will acquire size selective powdered samples from the extreme ambient (such as Mars or Venus surface). Then it will transfer and deliver samples to the analytical instrument(s) that are situated in a controlled environment such as a… more
Abstract:Software systems today are becoming increasingly complex because of the wide range of responsibilities they handle and the wide range of services they provide. The use of complex, high-speed, network-centric software-intensive systems is increasing within weapons and C4ISR systems and other… more
Abstract:The proposed work extends Probability Bounds Analysis to model epistemic and aleatory uncertainty during early design of engineered systems in an Integrated Concurrent Engineering environment. This method uses efficient analytic and semi-analytic calculations, is more rigorous than probabilistic… more
Abstract:Distribution and abundance of endangered species are adversely affected by changes in the land-use patterns that cause habitat loss, habitat fragmentation, pollution or other disturbances. As sensitivity to human impact on local, regional, and global ecologies increases, researchers, planners, and… more
Abstract:At present, there are opaque candles based-on hydrogenated vegetable oil waxes, and premium transparent container gel candles based on mineral oil gel. However, there are no commercialized technologies for transparent gel candles based-on vegetable oils. The purpose of this project is to synthesize… more
Abstract:The first critical step in welding or brazing is cleaning to remove surface contamination. The Air Force has a need for an environmentally cleaning method that has no waste stream, minimal requirements of personal safety protection, and does not impact component integrity. The Arc Scrubber is an… more
Abstract:DESCRIPTION (provided by applicant): Bridging the gap between science and practice continues as a major problem in the effective delivery of treatments for alcohol abuse and dependence. Twelve Step Facilitation, an empirically supported therapy, is well positioned to bridge this gap. That is,… more
Abstract:DESCRIPTION (provided by applicant): Bridging the gap between science and practice remains a significant concern in the effective delivery of treatments for drug abuse. Contingency management (CM) treatments, an empirically supported therapy, is well positioned to bridge this gap. Recent studies… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of this project is to develop an antagonist for the G-protein-coupled receptor FPRL1 (formyl peptide receptor-like 1) to test the hypothesis that blocking this receptor will prevent accumulation of inflammatory cells into plaques in… more
Abstract:The use of carnauba wax in melt/castable explosives yields a insensitive explosive formulation that enhances overall safety for the use of these munitions in the field. However, carnauba wax is only obtained from overseas sources and there is no domestic source for this material. This leads to… more
Abstract:One of the greatest technical challenge facing submarine communications is fielding antennas capable of high data rates required by future broadcast circuits. Example antennas include those for communications, navigation, and Identification of Friend or Foe (IFF) capabilities. As compared to surface… more
Abstract:Providing accurate PVT (Position, Velocity and Time) information is critical for network-centric warfare. The Global Positioning System (GPS) has become integral component for obtaining the PVT information on many DoD platforms. In addition of the weak signal power from GPS satellites, these GPS… more
Abstract:There is an increasing need for novel antenna apertures and surveillance components to address the network-centric environment envisioned for future Navy combat operations. Given the lack of available real-estate, the only viable approach is to reduce antenna size and increase aperture bandwidth to… more
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