Abstract:DESCRIPTION (provided by applicant): Description: Several neurological disorders, including Alzheimer's disease and frontotemporal dementia with parkinsonism (FTDP) are characterized in part by neurofibrillary tangles made up primarily of the protein tau. While useful mammalian models of tauopathy… more
Abstract:DESCRIPTION (provided by applicant): Description: The goal of this research program is to develop a rapid, in vivo assay for screening small molecules for their ability to protect or regenerate neurons in a whole vertebrate organism. In Phase I, dopaminergic neurons in zebrafish embryos, made easily… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this Phase I proposal is to automate the analysis of the Z-Tag angiogenesis assay and to screen a small collection of compounds for their potential angiogenic activity. For the latter, we propose to screen two sets of compound libraries. First, a… more
Abstract:Zyvex in cooperation with Prairie View A&M (CARR) and Boeing will develop a space radiation shielding multi-functional material that will provide high energy radiation shielding required to protect astronauts on extended missions, strong enough to be used as an integral structural material and tough… more
Abstract:DESCRIPTION (provided by applicant): The objective of this project is to develop an adenoviral vector vaccine against HIV that is effective in stimulating cell-mediated immunity in animals previously immune to adenovirus The HIV vaccine will be used to protect against infection and to treat the… more
Abstract:Envision Engineering plans to bypass the issues associated with the traditional use of thermoset plastics in the development of functional large ground-based radomes by instead using thermoplastic materials and innovative manufacturing processes to create a functional radome design for a radar… more
Abstract:The ReSINE(TM) concept, for Remote Stand-off Impulse Neutron Examination, proposed by ER2S, Inc., is a unique application of three fairly mature technologies providing a compact mobile system for detecting 10 kg of hidden explosives at distances up to 100 m. First, it is based on the Short Pulse,… more
Abstract:A new high-performance multi-functional structural/energy storage technology is sought for airframes. To overcome the limitations of technologies develop by other organizations, ACM proposes to demonstrate a new all-solid technology that utilizes carbon fibers and high-temperature polymers. The… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to develop unique column packings for high-performance liquid chromatography. These new materials will allow the very fast separation and characterization of both small molecules of biological and pharmaceutical interest and very large… more
Abstract:The project continues development of Proximity Sensing Textile as a wearable, electronic travel mobility aid tht preserves the comfort, appearance, and dignity of everyday apparel. Proximity Sensing Textile is a smart textile array of infrared sensors embedded in conventional clothng tht detects… more
Abstract:The proposed program will logically extend the Phase I activity, focusing on Excera's ONNEXT/BlueStarT armor technology. Based on a near-net shape process for producing ceramic composite materials, this effort will focus on both enhanced ballistic protection as well as structurally conformal armor… more
Abstract:American remote Vision Company (ARVC) will continue to research and develop a new non-pryotechnic latch and release sytem for use in servicing and flight release applications, among others. We have built and demostrated prototypes from the 20 pound range to the 2000 pound range. The devices are… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a new passivation technique, derived from a recent discovery that semiconductors can be readily hydrogenated by simultaneous exposure to hydrogen gas and ultra-violet light. The technique has a number of advantages over… more
Abstract:Divert and attitude control systems (DACS) for Exoatmospheric Kill Vehicle (EKV) and Kinetic Energy Interceptor (KEI) applications have severe constraints with regard to system mass and handling safety. These systems typically employ heavy gas bottles and regulators for pressurization at the high… more
Abstract:We will focus on developing the Net-Centric Collaboration Grid Middleware that is needed to build domain specific warfighter command & control (C2), decision support solutions within a net-centric grid-enabled environment. Based on the successful feasibility study that uses Grid of Grids… more
Abstract:DESCRIPTION (provided by applicant): Osteoporosis is a serious public health problem faced by an aging US population. In past decades, there has been significant progress, as well as controversy, in the diagnosis and treatment of osteoporosis. Until recently, bone screening was inaccurate and… more
Abstract:The U.S. Army has the need for small and efficient fuel cell power generation systems (2 kW) that can operate on diesel and logistic fuels. The advantages of employing these fuels for "in-the-field" power generation in military deployment include high energy density and wide availability. … more
Abstract:The objective of this program is to develop and demonstrate an advanced logistic fuel processing system that utilizes a novel regenerable desulfurization absorbent. The sulfur absorbent will operate efficiently at ambient pressure and be readily regenerable through exposure to air. The proposed… more
Abstract:Hydrogen systems can provide viable, sustainable options for meeting the worldÂ¿s energy requirements. This project will develop a novel, low-cost, hydrogen membrane with improved durability for the production of high-purity hydrogen from coal-derived syngas. These membranes would be used in… more
Abstract:This Small Business Innovation Research Phase I research project explores the development of a catalytically active filtration device for the continuous removal of particulate matter from diesel engine exhaust. A novel particulate filtration system that continuously oxidizes particulate matter and… more
Abstract:One of NASA's primary goals for the next decade is the design, development and launch of a spacecraft aimed at the in-situ exploration of the deep atmosphere and surface of Venus. The success of this mis-sion, called VISE (Venus In-Situ Explorer), is reliant on the development of effective thermal… more
Abstract:The innovation addressed in this proposal is Sprayable Thermal Insulation for Cryogenic Tanks, or STICT. This novel system could be applied in either an automated or manual spraying process, with much less sensitivity to process chemistry and environmental parameters than cur-rent spray-on foam… more
Abstract:NASA is seeking a high performance thermal insulation material for cryogenic applications in space launch development. Many of the components in cryogenic distribution systems at the launch site can be complex and require an insulation that can be formed to irregular shapes to minimize heat leak.… more
Abstract:NASA has expressed a need to identify and develop breakthrough technologies that have potential to provide increased scientific return at lower cost, and to enable missions and capabilities beyond current horizons. To make these missions feasible, advanced thermal materials are needed as thermal… more
Abstract:The Navy's vision is to transition all interior and exterior line of sight radio communications from analog to digital technology. Automated Digital Network System (ADNS) is one of the primary initiatives that would require the Navy's tactical systems, including voice, video, and data to… more
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