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Year:2006
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Displaying 901 – 925 of 6388 Awards
Company: BIOCATALYTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2006 / 2
Abstract: DESCRIPTION (provided by applicant): Chiral drugs comprise a steadily increasing percentage of new pharmaceutically-active substances, and their synthesis demands methods that can produce compounds with high stereochemical purity. Chiral alcohols are ubiquitous intermediates in the synthesis of… more
Company: BIOCATALYTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): Abuse of gamma-hydroxybutyrate (GHB) as a recreational drug is becoming increasingly more prevalent due to the general feeling of euphoria it produces when ingested in moderate levels. At higher levels, unconsciousness and coma can result making this the drug of… more
Company: BIOCOMPUTING GROUP, INC. Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): Peptides play a decisive role in many physiological processes and as a result are playing an increasing role in the development of vaccines and peptide, peptidomimetic, and small-molecule drugs. Because of an explosion of functional and structural-genomic data… more
Company: Biodesy LLC Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): Integrin receptors are critical cell surface proteins involved in cell adhesion and are important in tumor progression. Inhibitors of integrin receptors can be effective anti-cancer agents because they can prevent tumor adhesion and abolish integrin functions… more
Company: BIOELECTROMED CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): RPN Research has recently developed a new instrument called the Bioelectric Field Imager (BFI) that allows us to measure the surface potential of the skin without touching it. We have used the BFI to map the lateral electric field surrounding a skin wound in mice… more
Company: BIOENGINEERING CONSULTANTS, LTD Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): Ventilator-Associated Pneumonia (VAP) is pneumonia that develops in a mechanically ventilated patient later than 48 hours after intubation. The longer a patient is intubated, the greater the chance that pneumonia will develop. Pneumonia is the second most common… more
Company: BIOFACTURA, INC. Agency/Program/Year/Phase: DOD / SBIR / 2006 / 2
Abstract: The proposed effort aims to test the protective efficacy of full length VACV-specific human mAbs derived from a phage FAb combinatorial library in a series of relevant in vitro and in vivo studies. To date, two such mAbs have been partially characterized and shown to neutralize VACV replication in… more
Company: BIOFORCE NANOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2006 / 2
Abstract: DESCRIPTION (provided by applicant): The goal of this SBIR Phase II proposal is to continue and expand the development of microfabricated surface patterning tools (SPTs) for the construction of ultra miniaturized biomaterial arrays (nanoarrays). SPTs can be configured as either pre-loaded molecular… more
Company: BIOFORCE NANOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): The purpose of this Phase I feasibility study to design, construct and evaluate an ultraminiaturized sensor device capable of detect ng protein biomarkers from a few cells and, ultimately, single cells. The device, termed the nanobiosensor, consists of an array… more
Company: BIOHELIX CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): Molecular diagnostic tests that rely on the amplification of specific sequences to identify genes of interest frequently use the polymerase chain reaction (PCR). To perform PCR, sensitive and, often, expensive instrumentation is required for thermocycling, which… more
Company: BIO-IMAGING RESEARCH, INC. Agency/Program/Year/Phase: HHS / SBIR / 2006 / 2
Abstract: DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase II project involves the research and development of a real-time FPGA-based volume rendering system. Medical radiologists face a data overload crisis that is getting worse with each year. This crisis is caused by… more
Company: BioInsite Agency/Program/Year/Phase: NSF / SBIR / 2006 / 1
Abstract: This Small Business Innovation Research Phase I project aims to develop a sensitive and cost effective colorimetric bioassay for perchlorate determination in environmental samples. Perchlorate is known to affect thyroid hormone production potentially leading to neuropsychological development… more
Company: BIOLINK PARTNERS Agency/Program/Year/Phase: HHS / SBIR / 2006 / 2
Abstract: DESCRIPTION (provided by applicant): This project is focused on the development of a new type of chromatographic medium prepared by applying very thin polymeric coatings onto non-woven fabrics and having ion exchange groups suitable for adsorption and purification of large biomolecules. The… more
Company: BIOMARCK PHARMACEUTICALS, LTD Agency/Program/Year/Phase: HHS / SBIR / 2006 / 2
Abstract: Hypersecretion of mucus into the respiratory airways is a major contributing factor in several lung diseases, including chronic pulmonary disease (COPD), asthma, cystic fibrosis, and bronchiectasis. Despite the obvious medical importance, there presently are no effective therapies to control excess… more
Company: BIOMED SOFTWARE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2006 / 2
Abstract: DESCRIPTION (provided by applicant): Radiation sources are used throughout our society. By law, each radiation source must be properly shielded. Presently, design of shielded facilities or assemblies is performed via extensive and laborious hand calculations and with simple analytical tools that… more
Company: BIOMEDICAL ACOUSTICS RESEARCH COMPANY Agency/Program/Year/Phase: HHS / SBIR / 2006 / 2
Abstract: DESCRIPTION (provided by applicant): The long-term objective of this project is the introduction of "smart stethoscope" technology to immediately, accurately, safely, easily and inexpensively detect blood vessel compromise using computerized analysis of vascular sounds. The specific goal of this… more
Company: BIOMEDICAL DEVELOPMENT CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2006 / 2
Abstract: DESCRIPTION (provided by applicant): Oral candidiasis (oropharyngeal candidosis or thrush) is a common infection in immunosuppressed individuals, and, if not blunted, can transit to esophageal candidosis or life-threatening candidemia. These potentially life-threatening fungal infections originate… more
Company: BIOMEDICAL DEVELOPMENT CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): Irritant and allergic contact dermatitis affect approximately 10% of adults, and hand eczema represents one of the four most common occupationally related diseases, accounting for substantial lost earning potential in otherwise healthy populations. Both irritant… more
Company: BIOMEDICAL DEVELOPMENT CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): The goal of this project is to develop a safe biocidal vaginal gel for treatment of vulvovaginal candidiasis (WC). WC is caused by one of several airborne species of the yeast Candida that are normal inhabitants of humans at several sites, including the vagina. C… more
Company: BIOMEDICAL RESEARCH MODELS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): Approximately 1 out of every 5 Americans is infected with herpes simplex virus type 2 (HSV-2). Localized genital infection by HSV-2 results in painful recurring genital lesions while disseminated infection can involve multiple visceral organs and lethal… more
Company: BIOMEDWARE Agency/Program/Year/Phase: HHS / SBIR / 2006 / 2
Abstract: DESCRIPTION (provided by applicant): This SBIR project is developing the first geostatistical software to offer tools that are specifically designed for the analysis of health disparities, providing: descriptions of spatial patterns of cancer mortality rates and identification of scales of… more
Company: BIOMEDWARE Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): This SBIR Phase I project will develop methods, software and instructional materials for the accurate detection and description of cancer clusters and hotspots. Present state-of-the-art often relies on methods that were defined over a decade ago, do not… more
Company: BIOMIMETIC SYSTEMS, INC. Agency/Program/Year/Phase: DOD / SBIR / 2006 / 1
Abstract: Biomimetic Systems will develop and test a simulated system to localize and identify target sound sources including pistol, shotgun, and rifle fire. The software simulation will be a behavioral model of a proposed hardware system for Phase II development. Our system extracts novel feature sets… more
Company: BIONANOMATRIX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): The long term objective of this proposal is to develop a fully integrated chip and reader capable of single molecule analysis of linearized, native state genomic material. The anticipated embodiment will permit direct visualization and analysis of megabase… more
Company: BIONANOMATRIX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2006 / 1
Abstract: DESCRIPTION (provided by applicant): We are developing a nanochip device for manipulating long genomic DNA for high-resolution (kilobase), whole-genome analysis of cancer biomarkers such as gene amplifications, deletions, and translocations. These chromosome structural aberrations are strongly… more
Displaying 901 – 925 of 6388 Awards
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