Abstract:A cryogenic flow-control valve based on Venturi-Offset Technology (VOST) will be designed and modeled. VOST provides precise linear flow control within a hermetically sealed, thermally efficient, cylindrical envelope. Intended to demonstrate a breakthrough in cryogenic flow control, the valve has… more
Abstract:Two novel cryogenic couplings will be designed, fabricated and tested. Intended for in-space use at cryogenic propellant depots, the couplings are based on patented Venturi-Offset Technology (VOST) and will provide small fluid and heat leakage at high flows with a low pressure drop. Entirely… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will deliver simulations over the web for secondary and post-secondary science instruction which focus explicitly on students coming to understand the "nature of science." The nature of science implies that both the underlying logic of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project develops an automated compiler to translate software binary and assembly code of a general-purpose DSP processor into Register Transfer Level VHDL and Verilog code for subsequent mapping onto FPGA hardware. Recent advances in embedded… more
Abstract:NASA's vision of Space Exploration will require advancements in communication systems to maintain flexibility and adaptability to changing needs and requirements. The research outlined in this project will develop a hardware/software design environment that will allow NASA engineers to automatically… more
Abstract:DESCRIPTION (provided by applicant): Animal models for human disease are important tools for biomedical and pharmaceutical research. Pigs, like humans, develop hypertension, diabetes and cardiovascular disease and respond to stress by releasing hormones via the HPA axis. We propose to utilize pigs… more
Abstract:DESCRIPTION (provided by applicant): Dietary salt increases the risk of hypertension for some, but not all, individuals. But no method exists for assessing an individual's risk of salt-sensitive hypertension. We propose to develop an electrophysiological method of continuously monitoring the… more
Abstract:We propose to develop a computer based system for the online analysis of bio-behavioral signals associated with momentary loss of alertness. We will continue our development of bio-behavioral measures indicative of lapses in alertness. Our system will use only measures that can be obtained without… more
Abstract:DESCRIPTION (provided by applicant): Chiral drugs comprise a steadily increasing percentage of new pharmaceutically-active substances, and their synthesis demands methods that can produce compounds with high stereochemical purity. Chiral alcohols are ubiquitous intermediates in the synthesis of… more
Abstract:DESCRIPTION (provided by applicant): Abuse of gamma-hydroxybutyrate (GHB) as a recreational drug is becoming increasingly more prevalent due to the general feeling of euphoria it produces when ingested in moderate levels. At higher levels, unconsciousness and coma can result making this the drug of… more
Abstract:DESCRIPTION (provided by applicant): Peptides play a decisive role in many physiological processes and as a result are playing an increasing role in the development of vaccines and peptide, peptidomimetic, and small-molecule drugs. Because of an explosion of functional and structural-genomic data… more
Abstract:DESCRIPTION (provided by applicant): Integrin receptors are critical cell surface proteins involved in cell adhesion and are important in tumor progression. Inhibitors of integrin receptors can be effective anti-cancer agents because they can prevent tumor adhesion and abolish integrin functions… more
Abstract:DESCRIPTION (provided by applicant): RPN Research has recently developed a new instrument called the Bioelectric Field Imager (BFI) that allows us to measure the surface potential of the skin without touching it. We have used the BFI to map the lateral electric field surrounding a skin wound in mice… more
Abstract:DESCRIPTION (provided by applicant): Ventilator-Associated Pneumonia (VAP) is pneumonia that develops in a mechanically ventilated patient later than 48 hours after intubation. The longer a patient is intubated, the greater the chance that pneumonia will develop. Pneumonia is the second most common… more
Abstract:The proposed effort aims to test the protective efficacy of full length VACV-specific human mAbs derived from a phage FAb combinatorial library in a series of relevant in vitro and in vivo studies. To date, two such mAbs have been partially characterized and shown to neutralize VACV replication in… more
Abstract:DESCRIPTION (provided by applicant): The goal of this SBIR Phase II proposal is to continue and expand the development of microfabricated surface patterning tools (SPTs) for the construction of ultra miniaturized biomaterial arrays (nanoarrays). SPTs can be configured as either pre-loaded molecular… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this Phase I feasibility study to design, construct and evaluate an ultraminiaturized sensor device capable of detect ng protein biomarkers from a few cells and, ultimately, single cells. The device, termed the nanobiosensor, consists of an array… more
Abstract:DESCRIPTION (provided by applicant): Molecular diagnostic tests that rely on the amplification of specific sequences to identify genes of interest frequently use the polymerase chain reaction (PCR). To perform PCR, sensitive and, often, expensive instrumentation is required for thermocycling, which… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase II project involves the research and development of a real-time FPGA-based volume rendering system. Medical radiologists face a data overload crisis that is getting worse with each year. This crisis is caused by… more
Abstract:This Small Business Innovation Research Phase I project aims to develop a sensitive and cost effective colorimetric bioassay for perchlorate determination in environmental samples. Perchlorate is known to affect thyroid hormone production potentially leading to neuropsychological development… more
Abstract:DESCRIPTION (provided by applicant): This project is focused on the development of a new type of chromatographic medium prepared by applying very thin polymeric coatings onto non-woven fabrics and having ion exchange groups suitable for adsorption and purification of large biomolecules. The… more
Abstract:Hypersecretion of mucus into the respiratory airways is a major contributing factor in several lung diseases, including chronic pulmonary disease (COPD), asthma, cystic fibrosis, and bronchiectasis. Despite the obvious medical importance, there presently are no effective therapies to control excess… more
Abstract:DESCRIPTION (provided by applicant):
Radiation sources are used throughout our society. By law, each radiation source must be properly shielded. Presently, design of shielded facilities or assemblies is performed via extensive and laborious hand calculations and with simple analytical tools that… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this project is the introduction of "smart stethoscope" technology to immediately, accurately, safely, easily and inexpensively detect blood vessel compromise using computerized analysis of vascular sounds. The specific goal of this… more
Abstract:DESCRIPTION (provided by applicant): Oral candidiasis (oropharyngeal candidosis or thrush) is a common infection in immunosuppressed individuals, and, if not blunted, can transit to esophageal candidosis or life-threatening candidemia. These potentially life-threatening fungal infections originate… more
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