Abstract:With the ever-increasing number of human disease models, particularly in smaller animals, high resolution emission/transmission tomography techniques have become extremely important. The main barriers to using existing modalities in studies of laboratory animals have traditionally been poor spatial… more
Abstract:Scintillation detectors, consisting of inorganic scintillation crystals coupled to photomultipliers, are an important element of medical imaging applications, such as positron emission tomography (PET). However, the performance, as well as the cost, of these systems is limited by the properties of… more
Abstract:Nuclear and high-energy physics experiments often require detectors to face harsh environments, such as milli-Kelvin temperatures of a helium dilution refrigerator in high magnetic field of a few Tesla. Photomultipliers will not function in these magnetic fields, and existing silicon… more
Abstract:DESCRIPTION (provided by applicant): Title: High throughput and high sensitivity multi-well plate reader Project Summary/Abstract: The multi-well or microwell plate has become ubiquitous in research and clinical laboratories for processing multiple samples
with high speed and reproducibility. These… more
Abstract:DESCRIPTION (provided by applicant): Over 370,000 people in the US are hospitalized for traumatic brain injury (TBI) each year. In the US, the cost associated with the treatment, hospitalization and rehabilitation of TBI are estimated to be 48.3 billion a
nnually. A fast, easy, accurate and… more
Abstract:DESCRIPTION (provided by applicant): Recent extraordinary developments in synchrotron radiation sources have enabled the growth of powerful research techniques such as time-resolved X-ray diffraction studies for understanding dynamic biological phenomena a
nd recovering phase information in X-ray… more
Abstract:The EPA has stated a need for technologies and instruments to monitor and warn of the presence of toxic contaminants in drinking water. An innovative device that could detect, identify and localize hazardous chemical contaminants in drinking water would be immensely valuable to water utility… more
Abstract:Many commercially available digital dosimeters are bulky and are unable to properly measure dose for space radiation. The complexity of space flight design requires reliable, fault-tolerant equipment with the capability of providing real-time dose readings during a mission, which is not feasible… more
Abstract:Inorganic scintillation crystals are a very important element of the detection systems for current and next generation experiments in nuclear and particle physics. However, the performance of these detection systems is often limited by the properties of scintillators now available for neutron and… more
Abstract:Microfluidic chips, fabricated from low cost polymers, are a promising, emerging technology for the synthesis and study of new molecular imaging probes. These chips can contain a variety of microcircuitry and microwells, and are capable of manipulating nanoliter samples of reagents and solvents. … more
Abstract:Stereochemistry is an essential element of our organic life. Only certain enantiomers are useful as drugs for the human body. Raman optical activity (ROA) provides stereochemical information down to the bond levels. Many biomolecules like proteins and DNA can be studied to understand their… more
Abstract:We will fabricate and test microfluidic designs for a micro-electromechanical system based complete blood count (CBC) analysis in separate modules and integrate them into a working prototype. A first module constitutes a hydrodynamic focusing injector and cell impedance meter. A second module… more
Abstract:New technology is needed for sensing and characterizing incipient defects, and assessing the effects of aging in aerospace components. Next generation materials, including nickel-based superalloys that are exceedingly difficult to inspect with existing technology are being adopted by designers and… more
Abstract:80498S06 Nuclear medicine techniques such as Positron Emission Tomography and Single Photon Emission Computed Tomography have become powerful new tools for imaging biological processes in small laboratory animals. However, the performance of these systems is limited by the properties of the… more
Abstract:Active interrogation holds the most promise for detecting heavily shielded materials at a distance. This effort will use pulsed neutron excitation of fission reactions in the target being inspected in conjunction with an imaging detector. Special nuclear material (SNM) that is present will undergo… more
Abstract:80495S06 With the ever-increasing number of human disease models, particularly in smaller animals, high resolution emission/transmission tomography techniques have become extremely important. Such advanced imaging requires advanced detectors, and although detector technologies have improved… more
Abstract:81289S06 In many studies conducted with electron beam systems, the characteristics of available X-ray detectors limit the system performance. This project will investigate a novel low-capacitance design of high purity silicon detectors, which offers high energy resolution, high efficiency, high… more
Abstract:The Navy uses steam powered catapults to launch aircraft from naval vessels. Currently, after the aircraft is launched, the massive catapult mechanism is slowed to a stop by a complex water braking system. This water braking system has many moving parts and experiences high stresses during operation… more
Abstract:The proliferation of weapons of mass destruction such as nuclear missiles and "dirty bombs" are a serious threat in the world today and especially to the well-being of the United States. Preventing the spread of these nuclear weapons has reached a state of heightened urgency in recent years, more… more
Abstract:Third-generation synchrotron sources, such as the Advanced Photon Source (APS), are outstanding facilities for X-ray diffraction and scattering of non-crystalline biological materials. However, their full potential has not been realized because of the lack of detectors that can provide multiple… more
Abstract:Optical detectors are very important components of existing and future particle physics experiments, including those being developed for dark matter studies. However, the performance of experimental systems used in dark matter studies is limited by the properties of presently-available optical… more
Abstract:80613S06 Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Gamma-ray detectors are an important component of systems used to prevent nuclear proliferation. However, the performance of such systems is currently limited by the… more
Abstract:High-resolution scintillation crystals and crystal arrays are important components of current and future handheld and arrayed detectors (used for DOD applications) and scintillation spectrometers (routinely used in high energy physics research, medical imaging, diffraction, homeland security,… more
Abstract:The detectors available for neutron radiation are still inadequate, primarily limited by the available scintillators. Scintillators that can simultaneously provide high spatial resolution, high neutron detection efficiency, low gamma sensitivity, and fast response time do not exist. This project… more
Abstract:81146S06 Many contaminated facilities throughout the DOE complex will reside in a safe storage or surveillance and maintenance (S&M) mode until such time that funding resources are available to perform decontamination and demolition. Long-term monitoring systems are required to ensure against a… more
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