Abstract:Proliferation of weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Preventing the spread of nuclear weapons has reached a state of heightened urgency in recent years, especially since the events on September 11, 2001 and its aftermath. One way to passively… more
Abstract:DESCRIPTION (provided by applicant): Recently, with the increase in number of new neutron sources, stationary as well as portable, there has been growing utilization of neutrons in a similar manner. Contrary to X- and ?-rays, the probability of interaction
of neutrons with matter does not depend on… more
Abstract:DESCRIPTION (provided by applicant): Molecule specific targeting and improving image contrast have been recognized as important research areas in cancer imaging. Goal of cancer diagnosis and prognosis research is to develop new imaging techniques to detect
lesions with certainty in early stages so… more
Abstract:DESCRIPTION (provided by applicant): Summary Lead and its compounds have been rated as one of the leading chemicals posing the greatest threat to human health. Significant amounts of lead are found in a multitude of consumer goods, ranging from electronics
, household goods, to toys. In 1997, the… more
Abstract:DESCRIPTION (provided by applicant): LSO is generally recognized as the ideal scintillator for PET. It has high stopping power for 511 keV gamma rays, high light yield of over 20000 photons/MeV, and rapid decay of 32 ns. It achieves high coincidence timing
resolution and energy resolution. But… more
Abstract:This Small Business Small Business Innovation Research (SBIR) Phase I research project aims to develop a reagent that binds specifically to DNA mismatches for use in a microarray-based single nucleotide polymorphism (SNP) assay. Directed evolution will be used to isolate variants of a DNA repair… more
Abstract:DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a functional imaging technique with potential to quantify the rates of biological processes in vivo. The availability of short lived positron-emitting isotopes of carbon, nitrogen,
oxygen and especially fluorine allows… more
Abstract:DESCRIPTION (provided by applicant): Dedicated high-resolution small animal imaging systems have recently emerged as important new tools for cancer research. Of these systems, x-ray microcomputed tomography (microCT) shows promise as a cost-effective means
for detecting and characterizing soft… more
Abstract:DESCRIPTION (provided by applicant): Nuclear medicine imaging modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) are powerful, non-invasive medical imaging techniques that provide an image of the t
hree dimensional distribution of a… more
Abstract:DESCRIPTION (provided by applicant): The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) functional and anatomic images of living systems. Positron Emission Tomography (PET) offers high
sensitivity to a range of biological… more
Abstract:DESCRIPTION (provided by applicant): Information on the structure and function of proteins is important for unveiling biological processes taking place on a molecular level. X-ray crystallography has been successful in determining protein structure, howeve
r, it is not well suited for analyzing… more
Abstract:This Small Business Innovative Research (SBIR) Phase II reserach develops an innovative biotechnology for commercial production of natural astaxanthin using genetically improved microalgal strain(s) grown in a proprietary large-scale photobioreactor, and to demonstrate the effectiveness of the new… more
Abstract:DESCRIPTION (provided by applicant): The Big Idea driving this project is that human memory is small, the body of scientific knowledge is vast and that breakthroughs are possible if software can do a better job of connecting researchers with knowledge in
text and databases. The first step is to… more
Abstract:High conductivity (Hi-K) Carbon foam and Carbon-Carbon (C-C) composites are light-weight and offers the highest specific thermal conductivity (conductivity/ density) among engineering materials. Carbon foam and C-C have also been identified as ideal core materials for advanced high temperature heat… more
Abstract:There is a constant need to reduce the size and part counts of state-of-the-art (SOA) turbine engines. One already demonstrated solution, which offers significant weight and cost payoffs, uses advanced fuel-lubricated (fuel-lubed) bearing. The challenge associated with fuel lubrication is that the… more
Abstract:Current science for Mars and lunar exploration demands that fairly small diameter intact rock cores be acquired for geologic evaluation. Tools to acquire these cores must be light weight, draw minimal power, and induce low loads on their robotic platforms. Unfortunately no tools have yet been… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to develop a novel quantitative particle agglutination technology for improving the performance of detection of human immunodeficiency virus (HIV) antibody in body fluids.
The conventional particle agglutination… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to develop sensitive, specific and quantitative enzyme-linked immunosorbent assays (ELISA) for (1) measuring anti-RhD (anti-D) antibodies in patients at risk for Hemolytic
Disease of the Newborn (HDN), (2) screening… more
Abstract:The technical objectives of this SBIR proposal include the design verification of a frangible composite ILS Glideslope Tower that will maintain existing tolerances and mission performance capabilities. Zephyr Engineering Services' [ZES'] (formerly All-Tech Solutions, Inc. [ATSI] ), technical… more
Abstract:DESCRIPTION (provided by applicant): The objective of this work is to develop dual function antibacterial coatings that prevent biofilm formation and thrombus. A key feature of this technology is that it will prevent biofilm formation without an associated
risk of creating antibiotic resistant… more
Abstract:DESCRIPTION (provided by applicant): In current medical practice, breast biopsy serves as the gold standard for determining if a breast mass is benign or malignant. Mammography is the main imaging procedure (screening) for detecting suspicious findings wit
h its high sensitivity but its lower… more
Abstract:The objective of this proposal is to conduct a detailed design study in Phase I for the next generation space-based FUV imaging sensors that will yield key ionospheric parameters necessary for use with the forecasting models. At the end of Phase I, the design of Advanced Ionospheric Monitor using a… more
Abstract:The HMMWV vehicle has seen increasing weight due to the added anti-ballistic and anti-IED protection, whereas mainframe is not designed to function optimally. Ground mobility forces are conducting increased mounted operations from armored HMMWV/modified HMMWV's. As additional armor and equipment… more
Abstract:The ever-increasing size of computational structural mechanics (CSM) simulations in energy and other key national industries imposes a pressing need for commensurate increases in computational speed, in order to keep costs and computation times in check. This project will develop an innovative… more
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