Abstract:The ever-increasing size of computational structural mechanics (CSM) simulations in energy and other key national industries imposes a pressing need for commensurate increases in computational speed, in order to keep costs and computation times in check. This project will develop an innovative… more
Abstract:DESCRIPTION (provided by applicant): This proposal outlines a body of research to evaluate the cytotoxicity and therapeutic efficacy of radiolabeled alpha-melanocyte stimulating hormone (a-MSH) peptide analogs that target a-particle emitting radioisotopes
to the nuclei of melanoma cells. The… more
Abstract:DESCRIPTION (provided by applicant): NIH sponsored cancer researchers have been obtaining promising results using molecules radiolabeled with lead-212 in treatment for metastatic melanoma and disseminated colon and pancreatic cancers. Another isotope, radi
um-223 is being used in clinical trials in… more
Abstract:The proposed project consists of developing a prototype exciter/igniter unit that can operate to a subset of expected flight performance requirements. The main focus of this development effort will be the physical integration of a small, compact exciter with a "flight like" igniter or spark plug. … more
Abstract:DESCRIPTION (provided by applicant): The ultimate goal of the proposed work is to develop a compact, label free, sensitive and real-time platform capable of multiplex detection of biomarkers and pathogens using glycan microarrays. Glycans, which are predom
inant surface components of immune cells… more
Abstract:Advanced radiators are needed for military vehicles, to allow engine output to be increased to meet new performance requirements. These radiators need to transfer more heat to the cooling air, while simultaneously reducing radiator size, pressure drop, weight and cost. Altex has identified and… more
Abstract:Compact burners, capable of using a range of logistics fuels, are needed in support of fuel cell reformer systems. High efficiency, rapid startup and long term reliability are key criteria. Current spray burner and other designs have difficulty in meeting these objectives as a result of heat… more
Abstract:Airborne electric power needs are becoming substantial, versus airframe propulsion power. Also, these electric power needs are applied in very short timescales that are not compatible with conventional gas turbine engine response capabilities. For these cases, the engine output and electric power… more
Abstract:The Fischer-Tropsch (F-T) process, combined with feedstock pretreatment and gasification reactors, can be used to produce logistic fuels from a range of feedstocks, in combat theaters where military fuels are not available or too costly. However, current pretreatment and gasifier reactors are too… more
Abstract:Altex Technologies Corporation and Penn State University (PSU) have developed and demonstrated desulfurizers from 20 watts to 10 kWe for different logistic fuels and different fuel cell applications. In particular a 10 kWe Logistic Fuel Sulfur Removal (LFSR) system has been developed for Navy… more
Abstract:Although microchannel heat exchangers can greatly reduce heat exchanger size and weight, they are too expensive for most applications because of high fabrication costs. This project will develop an innovative heat exchanger that uses low-cost materials and a low-precision fabrication technique, in… more
Abstract:The high moisture content of biomass degrades its value as a fuel, feedstock, or animal feed. If the moisture content of biomass could be reduced, its Btu content and compatibility with boiler equipment would increase, and its shipping costs and decay would decrease. Unfortunately, current biomass… more
Abstract:There are over 480,000 trucks on US roads, and each vehicle produces up to 20 tons CO2, 420 lbs or CO, 11 lbs of particulates and 250 lbs of nitrous oxides per year, when idling, and producing auxiliary power needed for the drivers comfort. A Quiet Reliable and Compact Fuel Cell Based APU… more
Abstract:The work proposed under AF071-084 will investigate a new method and technology for solving the problems of situation awareness, cyber impact assessment, and attacker prediction. The new technology is couched in the Situation Management paradigm and is a variation of the case-based reasoning method… more
Abstract:The ILC accelerator project will require several thousand superconducting radio frequency (RF) cavities with critical RF Input Couplers. These cavities require ultra-clean vacuum and surface cleanness; however, the breakage of a ceramic RF coupler window, with the consequent inrushing of air and… more
Abstract:The future electron¿ion collider for nuclear physics requires a wide range of collision energies. However, operating a high-energy electron storage ring over a wide energy range imposes significant challenges ¿ i.e., maintaining high luminosity and high electron beam polarization ¿ due to… more
Abstract:Applications in high energy physics and other fields require the use of thousands of superconducting radio frequency (SRF) cavities made of high purity niobium (Nb) material. However, tantalum, the most prolific of metal inclusions, can cause thermal breakdown in these cavities. This project will… more
Abstract:The proposed effort will investigate optimized modulation formats, error-correction codes and coherent operation to improve high-bandwidth undersea communications. Analysis suggests that these methods can provide significant improvement over current optical communications methods.
Abstract:This Small Business Technology Transfer Phase I research project merges two powerful computer technologies: geographic information systems (GIS) and agent-based models (ABMs) to provide an agent-based geo-simulation toolkit that will help learners understand the complex causes of today's social… more
Abstract:DESCRIPTION (provided by applicant): Progress in sequencing the human genome has led to a new goal - expressing and characterizing the human proteome. A promising area where proteomics can have a major impact is autoimmune disease. Proteome-wide screening
against sera from patients with particular… more
Abstract:DESCRIPTION (provided by applicant): There are an estimated one million people in the U.S. infected with HIV-1, with 40,000 new cases reported each year. While most of these patients greatly benefit from highly active anti-retroviral therapy (HAART), they
often develop multi-drug resistance… more
Abstract:DESCRIPTION (provided by applicant): There exists an urgent need to develop an effective, non-invasive method of detecting colorectal cancer (CRC), the second leading cause of cancer deaths in the U.S. Such non-invasive testing, if instituted for a large s
egment of the population, could result in a… more
Abstract:DESCRIPTION (provided by applicant): Advanced Molecular Diagnostic Test for Neurofibromatosis ABSTRACT Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene. In children, NF1 causes learning disabilities, coor
dination problems and benign tumors later… more
Abstract:A key aim of the Army's Future Combat Systems (FCS) program is the development of enhanced remote sensing capabilities that provide commanders with improved situational awareness and battlefield shaping capabilities, while reducing potential casualties and manpower costs. Future Army WSN mission… more
Abstract:In Phase I, Ambient Micro successfully demonstrated the capability of its Multi-Source Ambient Power Supply module to simultaneously harvest and store energy from multiple ambient sources to extend the operating life of MEMS Vehicle Health Monitoring sensors for UAV-mounted sensor systems. As the U… more
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