Abstract:DESCRIPTION (provided by applicant): The purpose of this STTR Phase 1 application is to obtain proof-of-concept evidence that supports the indication of lobeline for the treatment of adult Attention Deficit Hyperactivity Disorder (ADHD). Research on the ne
urobiology of ADHD implicates abnormalities… more
Abstract:Large-volume CdZnTe detectors would improve radiation detection capabilities in support of the nonproliferation of nuclear weapons. However, the spectroscopic performance of current, large-volume Cadmium 10% Zinc Telluride, Cd0.9Zn0.1Te, (CZT) detectors is not sufficient for detection scenarios… more
Abstract:Eutrophication of environmental waters from the influx of nutrients can result in ecosystem
degradation caused by excessive plant and algae growth. Identification and prevention of the nutrient
loading problem can be addressed with measurements from deployed instrumentation only if… more
Abstract:PhaCTIV - Phase Change Thermally Initiated Venting System The Phase Change Thermally Initiated Venting System (PhaCTIV) consists of the following: 1) A structual plate (external) - low melt alloy - structual plate - thermal barrier (internal). 2) Structural plates are joined together with low-melt… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project will develop a method for improving the transmembrane conductivity of Nafion. This project proposes to develop a method for modifying the orientation of the conductive channels though which ions traverse in ionomer membranes. Shear… more
Abstract:This proposal presents techniques previously developed by Zeger-Abrams Inc. (ZA) that are directly applicable to the reduction of intermodulation product (IMP) distortion in a multicarrier power amplifier (PA). The use of adaptively controlled feedforward cancellation is proposed, plus the use of… more
Abstract:Zel Technologies proposes to provide a proof-of-concept prototype and demonstration of a system for mission-oriented network attack damage assessment and impact analysis based on top-down predictive analysis and modeling of potential effects-based adversary behavior. We will use results from… more
Abstract:DESCRIPTION (provided by applicant): Mesothelial cells have been found to be pivotal in tumor metastasis, peritoneal dialysis, and inflammatory response. These cells are specialized epithelial cells that line the peritoneal, pericardial, and pleural caviti
es and internal organs presenting a barrier… more
Abstract:DESCRIPTION (provided by applicant): The well documented rise in obesity over the past two decades correlates with increased incidence rates of metabolic and cardiovascular disease. In response to the associated reduced life expectancy and expensive health
problems the NIH has established an… more
Abstract:The Small Business Technology Transfer Research (STTR) Phase I project will result in the demonstration of an innovative new form of 3D lithography to be used for fabricating imaging arrays and photonic-crystal waveguides in thick photopolymers that are cheaper, higher performance, lighter, more… more
Abstract:This Small Business Innovation Research Phase I project will address the challenges of large-scale nonlinear optimization in the presence of discrete elements. Building on previous success with an integrated approach to classical, smooth nonlinear optimization, the goal of this research will be to… more
Abstract:ZIN Technologies, Inc. proposes a novel Miniature Treadmill with resistive exercise capability for use in spaceflight exercise countermeasures and broad terrestrial therapeutic applications. The treadmill device we propose will offer excellent periodic impact exercise to stimulate bone remodeling… more
Abstract:We propose here to develop tunable diode laser spectroscopy as a diagnostic for the Space Shuttle main engines during test stand operations. These engines represent the state-of-the-art in rocket engine propulsion systems, and as such, they stretch available technology to the limit. The engines must… more
Abstract:ZONA Technology, Inc. (ZONA) proposes a R&D effort to develop a Unified Nonlinear Flight Dynamics and Aeroelastic Simulator (UNFDAS) Tool that will combine proven simulation and visualization techniques to accurately match in-flight recorded dynamic behavior of an air vehicle.
ZONA proposes to… more
Abstract:Conventional air-vehicle designs are subjected to a well-set system/operational requirements. Scramjet-powered vehicle (SPV) design however enters an unprecedented level of multidisciplinary synergy to achieve its operational requirements. Through a convoluted and inverse design strategy for SPV,… more
Abstract:ZONA Technology, Inc. (ZONA) proposes a R&D effort to develop a Parameter-Varying Estimation (PVE) Toolbox that will rapidly evaluate and predict parameters that are required to certify an aircraft during flutter envelope and flying qualities programs. The work carried out successfully during the… more
Abstract:New approaches and techniques are required to effectively monitor and track radiological sources that are currently in use. We are proposing to develop a new class of monitoring and analysis methods that incorporate sensing information collected from zone-aware compact radiation detectors with… more
Abstract:In the production of ethanol from corn, the current process utilizes only the starch. Left unused is a significant amount of by-products, which also are produced during ethanol production. If these byproducts, which are rich in pentose and other sugars, could be made into a valuable product, the… more
Abstract:DESCRIPTION (provided by applicant): The emergence of compact, high-quality digital X-ray imaging detectors, together with nearly exponential growth in computing power and corresponding price reductions, allows for the potential of dedicated 3D breast ima
ging. X-ray mammography (XRM) has… more
Abstract:A novel microbolometer focal plane array is proposed for use at 8-14 m having very low noise, no required thermoelectric stabilization, contrast over a very wide range of object temperature, and projected low cost in manufacture.
Abstract:DESCRIPTION (provided by applicant): A major concern regarding drugs in development is cardiac toxicity. Commonly, drugs in development can cause changes to cardiac contractility, the force with which the heart beats, and cardiac rhythmicity, resulting in
toxic side effects. The purpose of this… more
Abstract:DESCRIPTION (provided by applicant): Our long term aim is to develop a galactosylated and sialylated platelet product that can be stored in the cold in order to prolong shelf life and minimize risk of bacterial growth. Currently, platelets can only be stor
ed at room temperature as platelets stored… more
Abstract:This Small Business Innovation Research (SBIR) Phase I research project aims to develop a point-of-care assay for creatine kinase, an important toxicity biomarker, to screen for adverse drug reactions (ADRs) using whole blood. The assay will utilize bioluminescent resonance energy transfer (BRET)… more
Abstract:DESCRIPTION (provided by applicant): Bacterial and viral meningitis and encephalitis is a major cause of morbidity and mortality in all societies of the world. The rapid progression of symptoms and potentially devastating effect of these diseases necessita
te early recognition and immediate… more
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