Abstract:Radar targets provide a rich scattering environment that produces from 5-25 dB target fluctuations. The spatial dependence of target scattering means that targets produce essentially independent scattering returns when radiated from sufficiently different directions. Thus, if receivers are… more
Abstract:Military aircraft come replete with interconnected electronic systems (e.g., communication, radar, and navigation systems). As the operating frequencies broaden and systems become more complex, their proper functioning is increasingly threatened by electromagnetic interference (EMI) from high-power… more
Abstract:This Phase I contract proposal will evaluate and identify markers associated with prostate cancer progenitor stem cells, that differentiate these cells from adult tissue stem cells and benign prostate progenitor cells. The eventual goal of this work would be to develop a high throughput blood-based… more
Abstract:The goal of this proposal is to develop directed energy transfer methods for imaging, tissue ablation and release of therapeutic modalities targeted to the vasculature of prostate cancer. The platform technology is a freeze-dried human platelet (Stasix par ticles) that contains super paramagnetic… more
Abstract:We aim to prepare a Phase I feasibility study of printed integrated circuits based on transistors using single wall carbon nanotube (SWCNT) fabrics. We propose to explore the feasibility of fabricating CNT circuits using ink-jet printing technology. A detailed literature and trade analysis review… more
Abstract:Operating across international borders in cooperation with a multitude of domestic and foreign institutions and scientists, the DOE needs to protect its high performance science networks (such as ESnet and USnet) from destruction by outside adversaries and rogue insiders. This project will develop… more
Abstract:DESCRIPTION (provided by applicant): Lung cancer is the world's leading cause of cancer deaths, with conventional therapies offering very limited benefit. Therefore, novel therapeutic approaches to improve outcomes of this disease are critical. Recent adva
nces in tumor cell biology have led to… more
Abstract:DESCRIPTION (provided by applicant): Liver fibrosis, a disease affecting tens of millions of patients worldwide, is the liver scarring response to chronic injury from viral hepatitis B or C, excessive alcohol use, iron overload or extrahepatic obstructions
and can progress to liver cirrhosis, liver… more
Abstract:DESCRIPTION (provided by applicant): Stroke is leading cause of morbidity and mortality in the US. Research on the pathophysiological basis of stroke has produced new paradigms for prevention and treatment, but translation of these approaches into improved
clinical outcomes has proved to be… more
Abstract:DESCRIPTION (provided by applicant): Lung transplantation is the only effective treatment modality for patients with end-stage lung disease. Ischemia-reperfusion injury, associated with the retrieval, storage and transplantation of the lung is a major immu
ne-independent factor adversely affecting… more
Abstract:DESCRIPTION (provided by applicant): Literature indicates that HGF via its cytoprotective and tissue-regenerative activities protects a number of organs against traumatic and/or ischemic injury and fibrotic/degenerative disease. We have evaluated the effec
ts of BB3/Rf in preclinical models of… more
Abstract:DESCRIPTION (provided by applicant): Emphysema is a major cause of death and disability afflicting approximately 2 million people, costing more than 2.5 billion in yearly health care expenses and causing or contributing to 100,000 deaths per year in the U
nited States alone. The disease is… more
Abstract:DESCRIPTION (provided by applicant): Percutaneous coronary intervention has become the mainstay for treatment of ST-segment elevation myocardial infarction (STEMI). Whereas early recanalization undoubtedly salvages myocardial tissue, reperfusion following
prolonged ischemia exacerbates injury.… more
Abstract:DESCRIPTION (provided by applicant): Currently approved drug-eluting stents are plagued by late-stage thrombosis and delayed restenosis. Acceleration of stent re-endothelialization can suppress neointimal hyperplasia, promote healing of the vessel wall, an
d decrease restenosis rates. Scatter… more
Abstract:In spite of the growing interest in developing games designed to target specific instructional objectives, and recent improvements accessibility of gaming technology, designing a game from scratch is still an expensive and time consuming endeavor, particularly for non-programmers working on a… more
Abstract:Despite the increased levels of application security offered by secure coprocessors, the barrier of entry into this realm has been prohibitively high for software developers. Coprocessors do not incorporate sufficient computational resources to host entire applications; therefore it is up to… more
Abstract:Currently deployed network security solutions focus on protecting authenticity and integrity, but NOT privacy and anonymity. And, current anonymity technology cannot be leveraged to rectify this situation for net-centric warfare infrastructures like GIG because it does not support highly dynamic… more
Abstract:The aim of this project is to demonstrate the feasibility of a fatigue lifetime tracking system for critical components used in rotary aircraft platforms. By incorporating neural network anomaly detection techniques, algorithms will be developed that track specific critical components and their… more
Abstract:Aniuk Consulting, LLC, proposes to create a GIS software toolkit for monitoring areal snow cover extent and producing streamflow forecasts. This toolkit will be packaged as multiple extensions for ArcGIS 9.2 and provides users with a means for easily ingesting NASA EOS satellite images (for snow… more
Abstract:DESCRIPTION (provided by applicant): A number of protein fusion toxins, composed of the diphtheria toxin (DT) toxophore and a targeting ligand, have been assembled and tested in Phase I clinical trials for the treatment of leukemias. To date, the only FDA
approved protein fusion toxin is ONTAK.… more
Abstract:DESCRIPTION (provided by applicant): The project seeks to further the development of a series of diphtheria toxin mutants which, when employed in the construction of protein fusion toxins, display reduced induction of leakage through vascular endothelial c
ell monolayers. The goals of this Phase I… more
Abstract:ANP Technologies proposes to integrate a commercially available air sample concentrator from ICx MesoSystems with our automated detection instrument that uses the NIDSr multiplexed assays and NIDSr Auto-Reader (AR) device. A trigger device may also be incorporated into the final system, which might… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project is focused on development of an innovative technology for fabrication of high-efficiency thin film nanocomposite photovoltaic materials and solar cells taking advantage of the recently discovered effect of carrier multiplication in… more
Abstract:This Small Business Innovation Research Phase I research project will fabricate a new generation of relief-free thin-plate semiconductor components of diffraction optics and photonic crystals operating in the infrared spectral region up to wavelengths of about 10 micrometer. The holographic… more
Abstract:Under complementary Phase II efforts, ATinc and DI will improve and integrate the System for Tactile Representation of Advanced Patterns (STRAP) and the Team Status and Signaling System (TS3) prototypes to create a bi-directional Haptic Automated Communication System (HACS), which will enable… more
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