Abstract:DESCRIPTION (provided by applicant): We are developing a new approach to image tumors by selectively targeting the tumors in vivo with a telomerase-specific replication-competent adenovirus expressing green fluorescent protein (GFP) (OBP-401). OBP-401 cont
ains a replication cassette in which the… more
Abstract:The proposed capability will model the debris flyout and the rubble volume resulting from a munition detonation. Fidelity will be tunable so that an application can model rubble effects ranging from a low fidelity point feature with volume and dimensional attributes, to a medium fidelity areal… more
Abstract:Design, fabricate and test a prototype for an apparatus capable of repeatable, multi-axis shock testing in loading regimes representative of the design-critical regimes experienced by a sensor mounted in a penetrating munition.
Abstract:This proposal defines a pathway to safely carry and dispense gasoline and other highly volatile fuels within enclosed spaces aboard Navy Ships, and in particular, the Littoral Combat Ship. This is necessary to accommodate the Combat Rubber Raiding Craft(CRRC) employed by SEAL detachments as well as… more
Abstract:DESCRIPTION (provided by applicant): In spite of recent advances, cancer remains a major killer posing a dire need for more effective therapy, and unfortunately this is particularly true for metastatic non-small cell lung cancer (NSCLC), which afflicts an
extremely large number of patients and is… more
Abstract:DESCRIPTION (provided by applicant): A need for better gene delivery has blocked the potential advancement in biomedical research and most critically development of better therapeutics that operate at the gene function level. This problem is most acute for
non-dividing cells, which in fact are the… more
Abstract:This Small Business Technology Transfer Phase I research develops a novel bioprocess platform for the synthesis of toxic enzymes as inactive pro-enzymes in bacteria that can subsequently be activated via simple pH and/or temperature shifts. Recombinant enzymes for industrial synthetic applications… more
Abstract:High-resolution tracking detectors based on Active Pixel Sensor (APS) technology have been valuable tools in Nuclear Physics and High-Energy Physics research, and have contributed to major discoveries. However, their integration time, radiation length and readout rate is a limiting factor for the… more
Abstract:To meet the increasing power demand of today's spacecraft systems, an integrated power electronics system capable of interfacing, and simultaneously controlling, three power ports is proposed in this project. This new proposed power electronic architecture employs a single-stage power topology, thus… more
Abstract:The objective of this proposal is to develop multi-echelon logistics management tools based on Agile principles and integrate them into the Manufacturing Repair Overhaul (MRO) environment. The Oklahoma City Air Logistics Center (OC-ALC) current processes are sub-optimized and focus on each… more
Abstract:The objective of this proposal is to develop inventory flow tools based on Just In Time (JIT) principles and integrate them into the Manufacturing Repair Overhaul (MRO) environment. The Oklahoma City Air Logistics Center (OC-ALC) current processes vary greatly based on the specific needs of an… more
Abstract:The USAF recognizes that benefits to cold working fastener holes include significantly increased life of a structure subjected to fatigue loading. However, full realization of this potential from a maintenance and engineering standpoint is hindered by the fact that there is currently no adequate… more
Abstract:DESCRIPTION (provided by applicant): ?9-tetrahydrocannabinol (?9-THC) has been shown to alleviate marijuana withdrawal symptoms and thus has potential for treating cannabinoid dependence. However, the bioavailability of ?9-THC administered orally is poor a
nd variable. In addition, it also requires… more
Abstract:DESCRIPTION (provided by applicant): Sphingolipids are being increasingly recognized as key mediators of inflammatory cascades of critical importance in multiple diseases, including rheumatoid arthritis and osteoarthritis. Most importantly, sphingosine
1-phosphate produced by sphingosine kinase… more
Abstract:DESCRIPTION (provided by applicant): Cervical cancer is one of the most common cancers affecting women and is a worldwide health problem. Unlike most cancers, cervical cancer is caused by a virus - the human papillomavirus (HPV). Two preventative vaccines
against HPV were recently licensed in the… more
Abstract:DESCRIPTION (provided by applicant): The objective of this NIAID Advanced STTR Phase I proposal is to combine the strengths of academic investigators from the fields of immunology and animal disease modeling with the resources of ApoImmune Inc. to develop
a novel vaccine, ApoVax104-TB targeting… more
Abstract:The objective in this project is the development of a monochromatic x-ray source for a small x-ray Photoelectron Spectrometer (XPS) suitable for NASA missions. This instrument will allow in situ elemental and chemical state measurements in off-earth NASA missions. The need for these measurements… more
Abstract:Appareo Systems, LLC, proposes to develop a functional prototype head-mounted position and orientation system (HPOS). The HPOS will be capable of operating in electromagnetic fields of up to 200 volts/meter and will provide at least one degree of accuracy and at least one degree of resolution at a… more
Abstract:To apportion resources wisely, decision makers need to estimate the location and importance of threats and vulnerabilities at local, regional, and national landscape levels. Dynamic, high quality, geographically explicit data are becoming more and more available for use as inputs to such predictions… more
Abstract:Forest insect pests cause significant economic and ecological damage every year. Dramatically increased pest activity in recent years suggests that changing climate conditions will inflate the uncertainty associated with pest risk assessments. Advances in forest pest risk analysis methodology are… more
Abstract:DESCRIPTION (provided by applicant): In delimited populations, such as nursing homes, day care centers, prisons, hospitals, and cruise ships, serious outbreaks of illness generally produce limited absolute numbers of disease incidence. Moreover, these grou
ps are often more susceptible to disease… more
Abstract:As a nation, we are faced with multiple challenges from global climate warming, rapid depletion of fossil oil, a strong desire to become independent from foreign oils, and a moral obligation to preserve our environment for future generations. In response to these challenges, many consumers have… more
Abstract:The first critical step in welding or brazing is cleaning to remove surface contamination. The Air Force has a need for an environmentally cleaning method that has no waste stream, minimal requirements of personal safety protection, and does not impact component integrity. The Arc Scrubber is an… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of the research is to develop and fabricate an instrument that can facilitate the discovery of new drugs via high throughput screening (HTS). ECIS (electric cell-substrate impedance sensing) is a
technology developed by Applied BioPhysics… more
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