Abstract:This SBIR Phase I project will develop a hand-held sensing and alarm system for ultra-trace concentrations of chemical gases, biological aerosols, and explosive vapors. Unprecedented sensitivity will be achieved by differential intracavity laser absorption spectroscopy (ICLAS) which provides up to… more
Abstract:During the Phase-I research we only spent 6 months (not 9 months) an air droppable rolling weight deflectormeter (ADRWD) was built and a conceptual demo at a small airport was successfully conducted. The Phase-II main objective is to refine the Phase-I design and build a lightweight working ADRWD… more
Abstract:DESCRIPTION (provided by applicant): Pathological angiogenesis, the growth of new blood vessels during a disease state, contributes to over 70 diseases, including cancer. The proposed studies are a Phase II SBIR grant application focused on the preclincal
development of novel anti- angiogenic small… more
Abstract:DESCRIPTION (provided by applicant): Kaposi's sarcoma is the most common cancer associated with HIV infection. It is caused by infection with Kaposi's sarcoma-associated herpesvirus (KSHV). In patients with HIV infection as well as in non-HIV-infected orga
n transplant recipients who are… more
Abstract:DESCRIPTION (provided by applicant): The objective of this project is to continue developing an adenoviral vector vaccine against CEA that is effective in stimulating cell-mediated immunity in animals previously immune to adenovirus. The Ad-CEA vaccine en
dpoint is to treat patients with CEA… more
Abstract:DESCRIPTION (provided by applicant): The Bcl-2 family proteins are key effectors of cancers. Recent studies indicate that Myeloma cell factor-1(Mcl-1), a member of this protein family, is a key regulator of lymphoid cancers including B-cell lymphoma, mul
tiple myeloma, and chronic lymphocytic… more
Abstract:DESCRIPTION (provided by applicant): Eva Pharmaceuticals, STTR Phase II Application, April 2007, Abstract Since their discovery, COX-2 inhibitors have dominated the market for non-steroidal anti-inflammatory agents (NSAIDs). In 2004, Vioxx(r), a major COX-
2 inhibitor, was removed from the… more
Abstract:DESCRIPTION (provided by applicant): In responding to HazMat emergencies, practice not only makes perfect, it also saves lives. Under the Phase I SBIR grant, Amethyst Research developed a software simulation tool called HazCommand. Our Phase II goal is
to create a model platform for… more
Abstract:DESCRIPTION (provided by applicant): Many recent studies have demonstrated the efficacy of interstitial ablative approaches for the treatment of hepatic tumors, including chemical ablation, cryoablation, and thermal ablation using energy sources like RF, l
aser, microwave, or focused ultrasound.… more
Abstract:DESCRIPTION (provided by applicant): High-Intensity Interstitial Ultrasound for Thermal Ablation of Uterine Fibroids. Benign uterine tumors (fibroids) are clinically apparent in up to 50% of women and typically require surgical removal of symptomatic fibr
oids or hysterectomy. Treatment options for… more
Abstract:DESCRIPTION (provided by applicant): This project proposes unique column packings for the fast high-performance HPLC of biomacromolecules. Initial focus will be on developing techniques to modify the chemistry of silica surfaces using hydrothermal methods,
so that biomolecular separations are… more
Abstract:This proposal exploits nano-materials to achieve exceptionally high energy in an 18650-size cell. The successful development of this cell will provide the Army with the highest energy density commercially available for years to come. This advancement in the cell capacity will lift military… more
Abstract:This proposal describes a superior high-energy density and high-rate, rechargeable, 18650-size cell for Army applications based on a novel, ultrasafe, high-energy, low cost nano-cathode material that is capable of fast recharges and high-rate discharging. The cell also incorporates a new nano-anode… more
Abstract:American Maglev Technology, Inc. (AMT) is pleased present this Phase II proposal of the Navy's Advanced Eddy Current Braking Technology STTR to develop a replacement for the Navy's high maintenance water brake. During Phase I, AMT and the University of Texas CEM proposed a unique, passive, reliable,… more
Abstract:High-performance infrared detectors are mission-critical components of each layer of the Ballistic Missile Defense System. MDA is investing heavily in technologies that enhance producibility/operability of LWIR/VLWIR infrared focal plane arrays (FPAs), and reduce BMDS life cycle costs. HgCdTe is… more
Abstract:The yield and operability of high performance infrared detectors, particularly those based on HgCdTe, are severely compromised by materials defects. Recently, ARI has demonstrated during its UV hydrogenation process that deuterium effectively 'decorates' defects in materials such as ZnCdTe and… more
Abstract:This SBIR Phase I research project is to improve the performance of CdZnTe based gamma ray detectors by passivating as grown defects through a hydrogenization process. These defects are a source of leakage current and contribute to the backgound noise of the detectors. Successful completion of… more
Abstract:The unsubsidized cost of electricity for small wind turbines is too high to achieve the widespread deployment goals of industry stakeholders. Guyed towers, which traditionally are the least expensive to erect, have a larger footprint, require more maintenance, and are less visually appealing than… more
Abstract:DESCRIPTION (provided by applicant): Treatment of metastatic tumors is a major health challenge. Recently, antibody-based therapies have been developed that are more specific and have fewer side effects compared with conventional chemotherapy. However, the
potency of most antibody therapeutics is… more
Abstract:DESCRIPTION (provided by applicant): The market for protein-based biopharmaceuticals is rapidly expanding. However, the clinical utility of many proteins is limited by their short serum half-life, requiring frequent injections. The most common approach to
improve serum half-life is PEGylation. The… more
Abstract:The proposed task creates the design for a robotic system (Unmanned Surface Vessel (USV))to control and conduct unmanned and unsupervised refueling of another USV. The concept uses an optimized boat design, light-weight low profile crane, boom end mounted robotic effector, novel hose end connection… more
Abstract:DESCRIPTION (provided by applicant): Hepatitis B is a major global health problem. About 350 million chronically infected people are at high risk for cirrhosis of the liver and liver cancer, resulting in appoximately a million deaths annually. Current va
ccines command a 1 billion annual market.… more
Abstract:DESCRIPTION (provided by applicant): Osteoporosis is a serious public health problem faced by an aging US population. Until recently, bone screening was inaccurate and models of fracture risk were relatively crude. A new radiological technique using measu
rements of the X-ray spectrum can perform… more
Abstract:A supported metal hydride with high gravimetric hydrogen density and high volumetric hydrogen density has been proposed for application as a hydrogen generating material for Army soldier-portable fuel cell generator requirements. The hydride is thermodynamically capable of releasing pure hydrogen… more
Abstract:A flameless personal water heater will be developed that is capable of heating small individual volumes of water for meal preparation, sanitation, or hygiene. The heater will react air and JP-8 in an enclosed flow path and transfer the heat generated to water. The device will be packaged into an… more
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