Abstract:DESCRIPTION (provided by applicant): RNA interference (RNAi) is a relatively new technology that enables the knockdown of expression of pathologic genes with short interfering RNAs (siRNAs). The limiting factor in the development of new RNAi medicines is d
elivery. The goal of the field is … more
Abstract:DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a severe degenerative condition of the brain that affects 1 million people in the U.S. PD is caused by the progressive neurodegeneration of the nigral-striatal tract in brain. The brain produ
ces endogenous neurotrophins that protect… more
Abstract:This Phase I program would examine the feasibility of developing an innovative mobile aircrew crashworthy seating prototype that allows the cabin crewmembers the freedom to perform the majority of their airborne tasks but also allows for easy and rapid repositioning or stowing of the seat to… more
Abstract:DESCRIPTION (provided by applicant): The aim of this project is to extend application of a novel liquid array' platform, based on Encoded Sortable Particle (ESP) technology, into the protein assay realm. ESPs are optically-encoded microfabricated particle
s that can be manipulated using magnetic… more
Abstract:The JHSV will reach speeds of 35+ knots and allow for the rapid transit and deployment of conventional or Special Operations Forces (SOF) as well as equipment and supplies. It is planned for an FY10 IOC. One of program's objectives is to reduce the Reception, Staging, Onward movement and… more
Abstract:This Small Business Innovation Research Phase I project proposes to attract and organize a revenue-generating, web-based, collaborative community of independent creatives - writers, photographers, animators, video producers, graphic artists, designers, musicians, etc. by providing web tools designed… more
Abstract:The primary goal of Phase I of this SBIR is an exploratory development to determine the instrument requirements needed to measure neutral winds in the upper atmosphere (90-300km) by passively measuring the Doppler shift of atomic oxygen airglow emission lines with a field-widened Doppler Asymmetric… more
Abstract:DESCRIPTION (provided by applicant): Critical Limb Ischemia (CLI) is a common problem that often results in major limb amputation. Circulating endothelial progenitor cells likely play a role in the pathogenesis of CLI; the number and function of these cell
s that are mobilized from the bone marrow… more
Abstract:DESCRIPTION (provided by applicant): Autoimmune diseases are thought to arise from abnormalities in innate or adaptive immune responses and most likely have both genetic and environmental components. Diagnosis of autoimmune disease is often difficult, as t
he symptoms can be relatively nonspecific.… more
Abstract:Previous research has shown Locus of Control, the sense of being able to directly influence outcomes, can be used to predict a broad range of behaviors, including the actions taken by pilots in potentially hazardous situations. The objective of this Phase I effort is to develop and validate a… more
Abstract:Artisan Laboratories Corporation proposes to develop high density, high performance RF over fiber technology. Artisan's approach to the technology is to design for high efficiency and high volume production that saves size, weight and power plus cooling by taking advantage of advanced modulation,… more
Abstract:DESCRIPTION (provided by applicant): Mesenchymal stem cells (MSCs) are one of the most extensively studied adult stem cells and have broad potential uses. A few of their uses include, studying developmental pathways, disease modeling, in vitro toxi
cology models, compound screening,… more
Abstract:This Phase II proposal extends the technique developed during Phase I for protecting CPI into a commercially viable and generally applicable source-to-source transformation engine. In addition, we expand the Phase I approach to support high-performance secure computation through careful division of… more
Abstract:DESCRIPTION (provided by applicant): This program will demonstrate the potential for commercial success of a novel approach for tracking and displaying the position and orientation of instruments in image-guided cancer interventions. Prototype systems will
be demonstrated in selected pancreatic… more
Abstract:Ascent Solar Technologies (AST) proposes to take the next step in spacecraft solar array development, building upon previous development to make the definitive thin-film photovoltaic (TFPV) device for high-efficiency (> 20%) and high-specific power (greater than 2000 W/kg) when combined with… more
Abstract:As technology advances, there is increasing demand for higher quality optics with fewer aberrations. Aspheric optics meet these needs, but at present there are no practical commercial systems to test these lenses. This keeps the costs high and stifles the market. ASE Optics proposes to develop a… more
Abstract:We propose to further the development of a secure integrity monitor for PCs. Its feasibility was determined in Phase I. It uses the System Management Mode of the Intel Pentium architecture (including compatible chips from AMD) to protect itself from tampering or interference by malicious software… more
Abstract:In recent work, this firm developed a highly promising, patented variable emittance technology based on electrochromic Conducting Polymers, with: (1) Thin (< 0.2 mm), flexible, lightweight (0.176 kg/m2), variable area (0.5 cm2 - 0.5 m2. (2) Impervious to flexing, micrometeoroids.(3) High Delta… more
Abstract:DESCRIPTION (provided by applicant): This project proposes to build and test a 20 L capacity Remediator for medical wastes. Infectious Medical Wastes (IMW), mainly from hospitals, represents a major component of hazardous wastes generated in the U.S.. In f
act, more than 4.5 million tons are… more
Abstract:DESCRIPTION (provided by applicant): This proposal seeks to leverage proprietary technical advances in Adeno-Associated Virus (AAV) vector mediated gene therapy to develop an AAV based Galanin gene delivery for the treatment of epilepsy. Asklepios Biopharm
aceutical, Inc. (Askbio) has obtained… more
Abstract:DESCRIPTION (provided by applicant): This proposal intends to advance the regional delivery of a chimeric adeno-associated virus (rAAV)-based, highly-truncated dystrophin (minidystrophin) gene therapy for the treatment of Duchenes Muscular Dystrophy (DMD).
Experiments focus on completing… more
Abstract:DESCRIPTION (provided by applicant): This NIDA STTR reapplication is to develop a personal digital assistant (PDA) format of a validated child self- report (Assessment of Liability and EXposure to Substance use and Antisocial behavior(c) or ALEXSA(c)) for
early harmful substance use, antisocial… more
Abstract:This project has two goals: (1) to develop and evaluate the feasibility of intelligent, computer-based self-management and household management applications that would improve the independent living capacity of persons with cognitive disabilities, and (2) to identify an agenda for full development… more
Abstract:This project will examine the feasibility of using alternative modes of execution on x86 processors as a means of providing protection for sensitive applications. The research will aim to answer two main questions: 1) can alternate modes of execution provide an environment that is suitable for… more
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