Abstract:The objective of this proposal is to demonstrate the ability of Beaver Aerospace and Defense to decrease the weight and cost of aircraft actuators while increasing their reliability. Aircraft actuators are a significant cost and safety concern to the Department of Defense. Beaver Aerospace and… more
Abstract:NASA has many needs for maintenance and repair technologies for long-duration human space missions. We propose to continue developing a compact, portable, vacuum-compatible, multi-axis Manipulator/Machining Center (M/MC) to satisfy many of NASA's needs. Our M/MC will provide complex manipulation… more
Abstract:The Navy is looking to develop a method for notching out tunable frequency bands from the output of a high power wideband jammer. The notches must be synchronized with rapid frequency hopping radios, tuning within 1 KHz in less than 1 uS. The method must support at least 8 notches, each reducing… more
Abstract:DESCRIPTION (provided by applicant): This is a Phase I Small Business Innovation Research (SBIR) grant application to support the development of an innovative, online training program to aid in the dissemination of exposure therapies (ETs) for anxiety diso
rders. ETs have consistently and robustly… more
Abstract:DESCRIPTION (provided by applicant): This is a Phase I Small Business Innovation Research (SBIR; R43/44) grant application to NIMH to support the development of an innovative, online training program in Panic Control Treatment (PCT). The current applicatio
n represents a cooperative partnership… more
Abstract:DESCRIPTION (provided by applicant): Persons with severe and persistent mental illness (SPMI) commonly experience both Substance Use Disorders (SUDs) and Borderline Personality Disorder (BPD), resulting in serious and complex personal costs and public heal
th problems. Although Assertive Community… more
Abstract:DESCRIPTION (provided by applicant): This is a Phase II Small Business Innovation Research (SBIR; R43/44) grant application to NIMH to support the further development and testing of an innovative, online training program in Panic Control Treatment for Adol
escents (PCT-A). The current application… more
Abstract:DESCRIPTION (provided by applicant): Interpersonal Psychotherapy (IPT) is one of the most thoroughly validated psychosocial treatments for depression. Dissemination of IPT, however, has been hindered by lack of trainers and didactic materials. Though sever
al excellent textbooks regarding IPT are… more
Abstract:DESCRIPTION (provided by applicant): Methylation is a ubiquitous and reversible covalent modification used to control the function of diverse biomolecules including their activity, stability and localization. Like phosphorylation, methylation is used to mo
dulate protein function, but in addition… more
Abstract:DESCRIPTION (provided by applicant): There is a high level of pharmaceutical interest in targeting enzymes that catalyze oxidation and reduction reactions for therapeutic intervention. Validated redox enzyme targets include HMG-CoA reductase, the target of
statin drugs like Lipitor that are used to… more
Abstract:DESCRIPTION (provided by applicant): In less than one year the 1918 Spanish flu pandemic claimed over 20 million lives worldwide, killing 675,000 Americans, more than 10 times the number of deaths to US servicemen in World War I. A similar strain of the vi
rus that caused the 1918 pandemic could… more
Abstract:Currently, there is no standardized process for assessing the accessibility of recreation elements used for outdoor recreation, picnic and camping facilities although standards for specific outdoor recreation elements exist, the Forest Service Outdoor Recreation Accessibility Guidelines and the… more
Abstract:Cities must perform detailed assessments of sidewalks and streets, including curb ramps, pedestrian signals, crosswalks, street furniture, and other components to determine compliance with the Public Rights-of-Way Accessibility Guidelines. However, current assessment methods are inadequate or… more
Abstract:The objective of this program is to develop adaptive optic laser mirrors which exhibit minimum distortion when irradiated with high power laser flux. Two approaches will be tried utilizing two sets of previously selected candidate materials. Results will indicate how to significantly improve the… more
Abstract:DESCRIPTION (provided by applicant): The primary long-term goal of this project is to develop a useful, practical, valid, and reliable tool to improve the quality of life (QOL) of people in dementia care settings. Specific objectives of this project includ
e developing and evaluating user-friendly… more
Abstract:DESCRIPTION (provided by applicant): This project will modify an existing emailed program to improve diet and physical activity (PA), by making it more appropriate for workers 55-64 years of age and by adding the ability to deliver automated interactive t
elephone messages and printed materials… more
Abstract:This Small Business Technology Transfer (STTR) Phase I research project proposes the development of the design features, sensory system and the control algorithm of an integrated powered knee-ankle power regenerative prosthesis. Despite significant advances in lower limb prosthetics over the past… more
Abstract:This Small Business Technology Transfer Phase I project seeks to create exoskeleton assist devices for workers in distribution centers and automobile assembly plants. By using these assistive devices, workers can dramatically reduce the load in the vertebrae of the lower back when maneuvering parts… more
Abstract:Fatigue life of airframe components is greatly influenced by many intrinsic and extrinsic factors. The nature of wide scattering in fatigue life makes it very difficult to design a component against fatigue failure. The huge consequences of life and property loss associated with premature fatigue… more
Abstract:DESCRIPTION (provided by applicant): This force-line vector visualization system will address prosthetists' and physicians' needs for a method of realtime displaying the ground reaction forces (GRF) generated during amputee ambulation coupled with images
of that movement. This method provides an… more
Abstract:Our TPS approach is to develop a foam core integrated structure consisting of a 3-D fabric reinforced ceramic matrix composite (CMC) outer skin connected to ceramic foam which in turn is connected to a polymer matrix composite (PMC) inner structure. The high temperature foam core element is load… more
Abstract:DESCRIPTION (provided by applicant): We are proposing to develop a new treatment for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective treatment. Of the 12,000 patients expected
to be diagnosed with GBM this year, most… more
Abstract:DESCRIPTION (provided by applicant): Carcinoma of the pancreas is the 4th leading cause of cancer deaths. The American Cancer Society has estimated 37,170 new cases and 33,370 deaths in 2007. The cancer generally develops without early symptoms and most pa
tients present to treating physicians with… more
Abstract:The Ballistic Missile Defense Shield (BMDS) developed by the United States Government relies on layered defense designed to defeat incoming missiles in boost, mid-course, and terminal phases of flight. To maximize effectiveness of the shield, two types of intercepting missile concepts exist: … more
Abstract:We do not offer a perfect simulation of social behavior. Instead we offer a digital sandtable where users can experiment with new ideas. Radically different interfaces meet the needs of radically different users. The system can be engaged at any of four levels, At the outermost level, it is a… more
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