Abstract:DESCRIPTION (provided by applicant): This SBIR application proposes development of an Information Technology Enabled Disease Management System for Treatment of Adolescent Depression (ITEMS-TAD). The need for this system innovation arises from the substanti
al costs that inadequately treated… more
Abstract:The Long Reach Drop-in Hotspot (LRDH) is a low cost technology that is easily and rapidly deployed to provide broadband Global Information Grid (GIG) connectivity to small teams in remote areas at virtually any time and place. The LRDH offers a low cost mission alternative to expensive resources… more
Abstract:Airborne Technologies, Inc. Phase II effort will be to build and demonstrate a low-cost marinized Unmanned Aircraft System (UAS) that can be operated easily from small or large vessels and is capable of reliable and repeatable operations in an ocean environment. The UAS will be utilized for… more
Abstract:Air-Lock, Incorporated is proposing to design fully sealed shoulder and arm bearings with interchangeable bearing housings. The interchangeable housings shall be utilized in trade studies to determine the optimal bearing profile and weight relative to the shoulder and arm position. It is assumed… more
Abstract:DESCRIPTION (provided by applicant): The general goal of this proposal is to assemble directed mutant gene sets quickly, cheaply, easily, and reliably. Mutant gene sets can share sub-assemblies, yielding savings of time, cost, and effort not possible if de
signed and assembled all as single genes.… more
Abstract:Today¿s solid-state lighting (SSL) products fall short of the key price and performance requirements needed to meet the complex demands of the general illumination market. Therefore, this project will develop novel encapsulants for LEDs that have the potential to improve light extraction… more
Abstract:DESCRIPTION (provided by applicant): The morbidity and mortality due to cardiovascular disease is attributed to the lack of significant replicative potential of adult mammalian cardiomyocytes. Thus myocyte loss in response to ischemic injury typically resu
lts in scar formation and a decline of… more
Abstract:DESCRIPTION (provided by applicant): More than 4.5 million Americans currently suffer from Alzheimer's Disease, a progressive neurodegenerative disease characterized by loss of memory, changes in personality, agitation, disorientation, loss of coordination
, and finally, total loss of day-to-day… more
Abstract:DESCRIPTION (provided by applicant): The objective of this Phase I study is to develop elastic, biodegradable ureteral stents that will degrade in the body within 2 weeks after a procedure. Current ureteral stents are made of non-degradable polymers and, u
nless they are permanent, have to be… more
Abstract:DESCRIPTION (provided by applicant): The objective of this Phase II study is to develop novel hydrogel-based tissue expanders that have delayed expansion with the property to be reshaped by the surgeon. Current tissue expanders either require external infl
ation or are immediately swelling… more
Abstract:DESCRIPTION (provided by applicant): Influenza viruses are highly contagious negative-sense RNA viruses cause approximately 114,000 hospitalizations and 20,000 deaths annually. Several drugs are approved by the US Food and Drug Administration (FDA) for tre
ating influenza infections, but successful… more
Abstract:The goal of this proposal is to fabricate a capacitor with an energy density of at least 4 J/cc that is durable over 10,000 cycles with an operational temperature range of -55 oC to 300 oC. This goal requires that a new thermally stable, high dielectric constant material be developed. It is… more
Abstract:DESCRIPTION (provided by applicant): Cisplatin is a widely used cytotoxic agent with therapeutic activity against various tumors, but also with substantial side effects, including nephrotoxicity, hepatotoxicity and myelosuppression. Therefore, a chemoprote
ctive agent which reduces the side effects… more
Abstract:The objectives of this proposal are to develop an animal surrogate finite element (FE) model and environment that can be used as a tool to investigate injury mechanisms and mitigation of traumatic brain injury (TBI) due to blast overpressure. A rat head model with a high degree of anatomical detail… more
Abstract:Rollovers result in significant civilian and military injuries and fatalities. Four technical gaps were identified in Phase I: lack of biomechanical data for rollover dummy design, numerous rollover test conditions needed to understand occupant kinematics
Abstract:There is a need to monitor the structural health of aerospace components operating in extreme temperatures ranges (e.g. -60 to +300C) and with high accelerations. Ideally the sensors employed for this task should be passive (i.e. not powered through batteries), permanently placed on the critical… more
Abstract:Polymers in space are subjected to various threats including hyperthermal oxygen atoms, UV and VUV photons, and ions. These threats can degrade the polymer and lead to static charge accumulation. This Phase II proposal will build on the Phase I work which demonstrated that inorganic films grown by… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Research Phase I project seeks to develop functionalized nanocoatings on fibers that will improve the adhesion of fibers to rubber. The better coupling of the… more
Abstract:DESCRIPTION (provided by applicant): To address the urgent need for better treatment and diagnostic testing of HIV infected people in resource-limited settings, we propose in this Phase II SBIR to further develop an electrochemical testing system (eSystem)
developed by Alderon Biosciences, Inc. for… more
Abstract:This Small Business Innovation Research Phase I project is an effort by Alditri Technologies, Inc. to nano-enhance fiber materials in order to capture parvoviruses. Specifically, Alditri will employ and seek to understand vapor-phase deposition technology as it applies to fiber materials to convert… more
Abstract:Better methodologies for the rapid detection of pathogenic bacteria and viruses are needed. A problem with current antibody-based assays is cross-reactivity with similar, but harmless, species. RMD, Inc., proposes developing nucleic acid-based affinity reagents (aptamers) against the spore coat… more
Abstract:Radiation Monitoring Devices, Inc. (RMD) in collaboration with Munro Ranging, LLC will develop an active laser sensor for autonomous satellite awareness systems. The instrument will be based on two innovative technologies developed by Munro Ranging and RMD to allow accurate and timely situation… more
Abstract:Current state-of-the-art X-ray imaging detectors use energy integration, where the simple integration of X-ray events during the exposure period forms images. Unfortunately, such indiscriminate operation is sub-optimal for digital radiography or CT imaging because of its inability to reject scatter… more
Abstract:New cerium-doped lanthanide halide scintillators have shown a strong potential to move beyond their familiar role in conventional gamma ray spectroscopy, toward fulfilling the needs of other highly demanding applications. However, issues related to the reliable, large volume manufacturing of these… more
Abstract:High-resolution scintillation crystals and crystal arrays are important components of current and future nuclear physics instruments and experiments. Unfortunately, the performance of the systems used in these experiments is often limited by the properties of the scintillation detectors presently… more
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