Abstract:DESCRIPTION (provided by applicant): Organ transplantation is one of the great success stories of modern medicine. However, the supply of suitable organs lags far behind the need and many patients die while waitlisted for organs. Current practice involves
donor preconditioning to stabilize organs… more
Abstract:UVCleaning Systems will develop a greywater remediation and recycling system for Army kitchen sanitation centers by combining COTS pre-filtration and ultrafiltration technologies, to reliably reduce all greywater contaminant concentrations except BOD to within the requirements of the solicitation,… more
Abstract:Aircraft avionics equipment must be cooled to maintain component reliability and longevity, particularly in high ambient temperature environments. Conventional cooling approaches fall short of performance, weight, compactness and cost requirements. Altex has identified an advanced air cooling… more
Abstract:To support tactical fuel requirements at forward sites, biomass wastes from operations and those locally available need to be converted into viable military fuels. Conventional approaches cannot produce military type fuels using compact and mobile reactors. Through recent efforts, Altex and PSU… more
Abstract:More compact and efficient cooling coils are needed to address increased heat management loads on Navy systems. Altex has identified an advanced cooling coil approach that can achieve the needed cooling, at half the typical cooling water flow, at face velocities exceeding 1000 fpm, without… more
Abstract:Conventional biomass densification and energy enhancement equipment is too costly for use in upgrading feedstocks for biofuels plants. Therefore, this project will develop an innovative biomass blending and densification system (BBADS) to densify biomass and upgrade the energy value. In Phase I,… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this project is to develop a tumor-targeted TCR-IL2 fusion protein, ALT-801, as an immunotherapeutic for treatment of p53-positive cancers. The TCR portion of this fusion protein is specific f
or a peptide derived from the… more
Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is to create immunotherapeutics based on two high-affinity, HIV-specific, soluble T cell receptors (TCRs) as targeting molecules for HIV-infected cells. These human-derived TCRs were selected b
ased on their ability to recognize HIV… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this proposal is to develop tumor-targeted TCR-IL15 fusion proteins as immunotherapeutics for treating cancers. Previous proof-of-concept studies with TCR-IL2 and TCR-IgG1 fusion proteins in m
ouse tumor efficacy models demonstrated the… more
Abstract:The Ballistic Missile Defense System (BMDS) requires a method for a distributed, near real-time, security management system that provides comprehensive situational awareness of the Information Assurance state of the BMDS and its components. Altusys has de
Abstract:AM Biotechnologies (AM) will develop a diagnostic system in response to SBIR Topic X10.01 Reusable Diagnostic Lab Technology that will simultaneously detect and quantify numerous protein biomarkers with excellent sensitivity. AM will enhance the current clinical gold standard immunoassay… more
Abstract:DESCRIPTION (provided by applicant): Systemic Anaplastic Large Cell Lymphoma (ALCL) is the most common T-cell lymphoma in children. ALCL is characterized by its anaplastic cell morphology and high level expression of CD30 on the cell surface. This diffuse
and homogeneous CD30 expression in ALCL… more
Abstract:In response to OSD/NAVY's need for landing gear component applications, We propose to develop advanced high strength steels using CDC compaction manufacturing. Common materials used are 4340 steel, 300M, and AerMet 100. AerMet 100 has superior material properties to 4340 and 300M. Landing gear… more
Abstract:In response to MDA's needs for non-eroding throats for controllable axial upper stages , UTRON proposes an innovative near net shape fabrication technology called High Pressure Combustion Driven Powder Compaction (CDC) with tremendous potential for cost-effective manufacturing of advanced cermet… more
Abstract:This Small Business Innovation Research Phase I research project will use femtosecond laser machining to fabricate Lithium ion based nanobatteries composed of arrays of nanocells. In addition, an array of addressable batteries will also be constructed. A femtosecond laser is a powerful tool to… more
Abstract:DESCRIPTION (provided by applicant): There is an urgent need to develop an effective method for detection of primary and recurrent bladder cancer. Bladder cancer is the fourth most common malignancy in men and the ninth most common malignancy in women in W
estern countries. If identified early,… more
Abstract:DESCRIPTION (provided by applicant): A key rationale of this project is the growing need for an improved low-cost, high sensitivity multigene mutation profiling method for tumors. An important example is the recent recommendation of the National Comprehens
ive Cancer Network (NCCN) to screen all… more
Abstract:A dc-dc converter with integrated Magnetics and sensor and ZVS, ZCS circuit topology in one package to reduce the interconnects and the losses is proposed. The custom made three dimensional magnetic design will allow us to increase the switching frequency to >500kHz, while maintaining >92%… more
Abstract:A network of the Distributed exportable power Generation "DG" with each DG capable of having local power and energy management. The main power and energy control is based on the real time power generation and the reserve capacity of the DG unit. All DG units communicate via CAN J1939 with local and… more
Abstract:DESCRIPTION (provided by applicant): Fragile X Syndrome (FXS), is the most common form of inherited mental retardation, affecting 1 in 4000 males and about 1 in 6000 females of all ethnicities. Additionally, carrier frequencies are quite high. About 1 in
250 females carry Fragile X and about 1 in… more
Abstract:DESCRIPTION (provided by applicant): The overall objective for this project is to develop and implement a comprehensive set of technologies to improve screening and diagnosis of conditions associated with Fragile X Syndrome (FXS). FXS is caused by an expa
nsion of a cytosine-guanine-guanine (CGG)… more
Abstract:DESCRIPTION (provided by applicant): Malignant melanoma is the least frequent but the most aggressive and deadliest form of skin cancer. Early detection and accurate staging are therefore crucial to ensure timely intervention and a good prognosis. Our long
-term goal is to develop a microRNA (miRNA)… more
Abstract:DESCRIPTION (provided by applicant): In the United States, lung cancer has the highest incidence and the highest mortality rate of all cancers. An estimated 215,020 new cases of lung cancer and an estimated 161,840 deaths from lung cancer will occur in the
United States during 2008. This high… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this project is to develop a comprehensive molecular diagnostic assay for the detection of clinically relevant genetic abnormalities in patients with acute myeloid leukemia (AML), chronic myel
ogenous leukemia (CML), and… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop and implement an integrated suite of technologies for enabling microarray-based diagnostic assays and the cGMP manufacturing processes and procedures necessary to manufact
ure these products. Microarrays have found… more
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