Abstract:DESCRIPTION (provided by applicant): Diabetic and non-diabetic nephropathies and the Metabolic Syndrome are associated with chronic kidney disease (CKD) - a program comprising proteinuria, accumulation of profibrotic collagen in the renal interstitium and
relentless decline in renal function. CKD… more
Abstract:DESCRIPTION (provided by applicant): Kidney transplantation is the most effective therapeutic modality for end-stage renal disease; it offers a better quality of life and a longer survival. Despite improvements in surgical and organ preservation techniques
over the last decade, renal dysfunction… more
Abstract:DESCRIPTION (provided by applicant): A significant body of literature indicates that Hepatocyte Growth Factor (HGF) via potent and direct anti-fibrotic activity protects many organs from the fibrosis-driven pathology. In addition, HGF has been shown to a
lso promote muscle progenitor cells to… more
Abstract:DESCRIPTION (provided by applicant): Ischemic Stroke continues to be a major cause of morbidity and mortality in the United States. Currently approved thrombolytic therapy suffers for a narrow therapeutic window and clearly other therapeutic strategies are
needed, such as neuroprotective or… more
Abstract:DESCRIPTION (provided by applicant): Emphysema is a major cause of death and disability and afflicts approximately 2 million people. The disease cost more than 2.5 billion in annual health care expenses and causes or contributes to the death of 100,000 pe
ople each year in the United States alone.… more
Abstract:DESCRIPTION (provided by applicant): Stroke is leading cause of morbidity and mortality in the US. Research on the pathophysiological basis of stroke has produced new paradigms for prevention and treatment, but translation of these approaches into improved
clinical outcomes has proved to be… more
Abstract:DESCRIPTION (provided by applicant): Literature indicates that HGF via its cytoprotective and tissue-regenerative activities protects a number of organs against traumatic and/or ischemic injury and fibrotic/degenerative disease. We have evaluated the effec
ts of Refanalin/BB3 in preclinical models… more
Abstract:DESCRIPTION (provided by applicant): Kidney transplantation is the most effective therapeutic modality for end-stage renal disease. Given the increasing demand for donor kidneys, more centers today are transplanting kidneys that were previously considered
unsuitable. Extended donor kidneys include… more
Abstract:This proposal offers a detailed work plan to conduct the research and development tasks necessary to produce a system for use by U.S. military planners and their U.S. Government interagency partners to access relevant lessons learned and reachback capabilities in stabilization and reconstruction… more
Abstract:This proposal offers a detailed work plan to conduct the research necessary to determine whether a correlation exists between soldiers and Marines surviving their first few firefights and long-term survival in a combat environment. If sufficient evidence is found to establish a correlation, the… more
Abstract:The need for a rational strategy to manage the evolution of user interfaces (UI) during block upgrades in complex tactical weapon systems has been a daunting, and costly, challenge for all services, especially the Navy. The emergence of open and Service-Oriented Architectures has exacerbated this… more
Abstract:This proposal offers a detailed work plan to conduct the research and development tasks necessary to produce a system composed of software, application servers, PCs, and handheld computers for use by highly-mobile military personnel to collect and process cultural information, intelligence, and data… more
Abstract:The aim of this project is the development of advanced software modeling tools for data mining, maintenance support, and structural health monitoring prognostics. The project will develop new modeling, optimization tools and algorithm concepts that provide database search and correlations… more
Abstract:Aniuk Consulting, LLC, proposes to create a GIS software toolkit for easily converting NASA HDF-EOS data into formats that can be readily used within a Geographic Information System (GIS) or other geospatial software programs. The Hierarchical Data Format (HDF) is a widely used scientific data… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research (SBIR) Phase II project will develop a new generation of relief-free thin-plate components of diffractive optics operating in the infrared region of spectrum.… more
Abstract:While a significant research has been conducted examining the transfer of training from VEs. Currently fidelity requirements are determined by performance measurements and subjective evaluations. It is often difficult to identify the specific design components that directly relate to transfer of… more
Abstract:The EVA digital radio imposes tight constraints on power consumption, latency, throughput, form factor,
reconfigurability, single event upset and fault tolerance, and security. This requires a complete rethink on
the digital radio architecture. We propose such an architecture called CHANDRA that… more
Abstract:We propose to develop a compact and rugged source of cold atoms for atom-based sensors. Our proposal encompasses the laser system, vacuum cell, and electronics required to achieve micro-Kelvin temperatures for 10^8 atoms with a repetition rate faster than 500 ms. We will run simulations and… more
Abstract:We propose to design a compact inertial sensor based on light pulse atom interferometry that has both single-axis rotation and acceleration outputs. In previous work, members of our team have developed several generations of ultra-high performance sensors that successfully demonstrated this… more
Abstract:DESCRIPTION (provided by applicant): Numerous research publications have demonstrated the benefits of continuous glucose monitoring for better glucose control and reduced glycated hemoglobin (HbA1c) levels; however, to improve efficacy, significant improve
ments in the performance of implanted… more
Abstract:DESCRIPTION (provided by applicant): Development of rationally designed vaccines is an important need that nanotechnology has tremendous potential to transform. Already nanoparticle developments are incorporated into approved small molecule therapeutics. A
dvances are making rapid progress toward… more
Abstract:DESCRIPTION (provided by applicant): A novel bioprocess platform, involving synthesis of peptide and protein biopharmaceutical products as fusions with a synthetic anchor protein in bacteria, and subsequent proteolytic cleavage, has been developed. The u
nique features of the system allow for the… more
Abstract:Laser optical communications offer the potential to dramatically increase the link bandwidth and decrease the emitter power in long-range space communications. Newest system designs require photon-counting arrays operated at high detection efficiency, tens of picoseconds temporal resolution, and… more
Abstract:This proposal responds to the Army's effort to fuse image intensification with infrared technologies and to rapidly meet warfighter's protection needs. Small, lightweight, low cost, high-sensitivity solid-state infrared cameras widely disseminated on the battlefield would revolutionize land warfare.… more
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