Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer (STTR) Phase I project will result in the demonstration of non-toxic multi-modality nanoparticle-based molecular probes for in vivo imaging. The objective of the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will demonstrate the detection of an established target in cancer diagnosis and treatment using new targeted Bioluminescence Resonance Energy Transfer to Quantum Dots (BRET-QD) technology. BRET-QD offers substantial advantages over… more
Abstract:DESCRIPTION (provided by applicant): The objective of this project is to continue developing an adenoviral serotype 5 (Ad5) vector vaccine against Ad5[E1-, E2b]-Her2/neu that is effective in stimulating cell-mediated immunity (CMI) in animals previously i
mmune to Ad5. The Ad5[E1-, E2b-]- Her2/neu… more
Abstract:DESCRIPTION (provided by applicant): Current generation Adenovirus (Ad) vector vaccines deleted at the E1 or the E1, E3 regions have resulted in experimental potential to immunize against a variety of infectious diseases such as HIV. These Ad vectors permi
t the delivery of genes, which express… more
Abstract:DESCRIPTION (provided by applicant): The objective of this project is to continue to develop an adenoviral vector vaccine against CEA that is effective in stimulating cell-mediated immune responses in subjects previously immune to Adenovirus. The Ad-CEA v
accine endpoint is to treat patients with… more
Abstract:DESCRIPTION (provided by applicant): Many recent studies have demonstrated the efficacy of interstitial ablative approaches for the treatment of hepatic tumors, including chemical ablation, cryoablation, and thermal ablation using energy sources like RF, l
aser, microwave, or focused ultrasound.… more
Abstract:New methods and technology to rapidly characterize UHTC creep are necessary to fully understand and exploit their high temperature properties for hypersonic vehicles and rocket nozzles. Recently, the University of Michigan has developed a rapid, table top apparatus for characterizing the oxidation… more
Abstract:New composite manufacturing technology is urgently needed to improve rotocraft (and non-rotocraft) performance via further integration of composite materials. Recently, Advanced Ceramics Manufacturing (ACM) developed a system of water soluble composites tooling materials that has potential to… more
Abstract:DESCRIPTION (provided by applicant): In the past decade effective therapies have been developed for diabetic retinopathy (DR), but all too many diabetics who are at high risk for developing the more advanced stages of diabetic retinopathy fail to get even
the annual eye exams recommended by AAO,… more
Abstract:This project will focus on research and development to provide individuals with visual impairments a clothing-based platform that supports the function of existing Global Positioning Systems (GPS) way finding systems. The clothing platform will lead to the integration of GPS way finding… more
Abstract:An inherently rugged Universal Oscillator (UO) is needed to enable a superior class of configurable communications for NASA applications. The requirements are a low phase noise RF output concurrently with a rugged, reliable, small, power efficient, and frequency tuning ability. VIDA Products has… more
Abstract:The anytime-cognition SBIR effort will identify promising software architecture and algorithms for designing a human-machine system that improves distributed collaborative decision making in network centric environments. A survey of available techniques and technologies will be performed to… more
Abstract:This proposal exploits nano-materials to achieve exceptionally high energy in an 18650-size cell. The successful development of this cell will provide the Army with the highest energy density cell commercially available for years to come. This advancement in the cell capacity will lift military… more
Abstract:Given that the earth is more than 70% covered by water, the potential for converting these renewable resources to electricity is many times that of other resources. In the conversion of wave and water-current energy to electrical energy, gears are used as a convenient way to convert the slow-speed,… more
Abstract:Yields and operability of high performance infrared focal plane arrays (IRFPAs), particularly those fabricated in HgCdTe, are severely impacted by material defects introduced during growth and/or processing. Amethyst Wafer Mapping (AWM) is a materials characterization technology which when fully… more
Abstract:Type II strained layer superlattice (SLS) p-n diode arrays fabricated on domestic-source GaSb substrates are a promising route to meet the critical need within DoD for large area, large format array infrared detectors. However, current SLS material quality is limiting detector performance. A… more
Abstract:DESCRIPTION (provided by applicant): Advances in treatment strategies have increased the long-term survival of children with acute lymphoblastic leukemia (ALL). However, the outlook of infants with ALL remains dismal with long-term survival rates of only 3
0-50%. Therefore, new treatments are… more
Abstract:DESCRIPTION (provided by applicant): One of the major problems in the fight against cancer is the intrinsic or acquired resistance of tumors to current cancer treatments, particularly that associated with multidrug transporters (MDT; e.g. P-glycoprotein (P
-gp) and the multidrug associated protein… more
Abstract:DESCRIPTION (provided by applicant): Systemic treatment with the bacterial flagellin protein, a Toll-like receptor 5 (TLR5) agonist, provides protection against high dose radiation through activation of nuclear factor-(B (NF-(B). NF-(B signaling induces mu
ltiple factors that contribute to cell… more
Abstract:The cost of electricity for small wind turbines is too high, and the installation process is too cumbersome, to achieve the widespread deployment goals of industry stakeholders. Guyed towers, which are traditionally the least expensive to erect, represent one approach to cost savings, but these… more
Abstract:The objective of this proposal is to demonstrate the feasibility of generating realistic ocean-like ground planes for the RCS prediction of small vessels in both shallow and deepwater environments. Although significant progress has been made in furthering the state-of-the-art in electromagnetic… more
Abstract:The proposed Phase II effort will build upon the success of the Phase I work by improving the low temperature hydrogen release characteristics of nanostructured hydride materials, scaling up the synthetic method, constructing a compact hydride-based hydro
Abstract:Small diesel gensets (less than 5 kW) used by the military are often sized for maximum loads, but are run usually run at only partial load. This leads to poor fuel economy, wet-stacking, and the reliability problems associated with it. Aspen Products Group, Inc. proposes to eliminate the problem of… more
Abstract:A flameless JP-8 combustion and heat transfer technology will be developed for use in man-portable field-kitchen appliances. The technology developed is based on diffuse combustion on catalyst-coated heat transfer surfaces, and use of a passive fuel vaporizer. By using the passive vaporizer and… more
Abstract:Oxygen-blown coal gasification and combustion provide promising pathways to highly efficient coal-based energy generation without carbon emissions. However, the processes currently used to generate large-volume oxygen streams tend to be capital and energy intensive, resulting in higher electricity… more
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