Abstract:This Small Business Innovation Research (SBIR) Phase I project focuses on the production of xylitol from glycerol, a byproduct of biodiesel production. By converting crude glycerol to a value-added coproduct there will be significant improvement in biodiesel production economics. Xylitol has health… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this proposal is to create a robust one pot, in vitro, multi-gram scale synthesis of activated sugars for drug discovery and biochemical research purposes. Natural product glycosylation is vital for
the discovery of new pharmaceutical… more
Abstract:DESCRIPTION (provided by applicant): This proposal combines the expertise of world renowned medical center collaborators with the experience obtained from our SBIR Phase I project to provide a 3rd generation 3D breast CT scanner suitable for a planned pati
ent trial. X-ray mammography (XRM) has… more
Abstract:This Phase I SBIR will demonstrate the feasibility of a process to create multi-layer thin-film optics for the far-infrared/sub-millimeter wave spectral region. The process will create alternating sub-wavelength layers of window and air with high index contrast. The process proven in Phase I will… more
Abstract:A high sensitivity, high spectral resolution, rapidly tunable imaging terahertz spectrometer is proposed for seeing through barriers, identifying dynamic targets, and tracking threats while providing continuous chemical analysis of objects in the field of view BENEFIT: USAF and other DoD… more
Abstract:This SBIR Phase II project is to develop a hand-held sensing and alarm system for ultra-trace concentrations of chemical gases, biological aerosols, and explosive vapors. Unprecedented sensitivity will be achieved by intracavity laser absorption spectroscopy (ICLAS) which provides kilometer… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer (STTR) Phase I project will result in the demonstration of non-toxic multi-modality nanoparticle-based molecular probes for in vivo imaging. The objective of the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will demonstrate the detection of an established target in cancer diagnosis and treatment using new targeted Bioluminescence Resonance Energy Transfer to Quantum Dots (BRET-QD) technology. BRET-QD offers substantial advantages over… more
Abstract:DESCRIPTION (provided by applicant): The objective of this project is to continue developing an adenoviral serotype 5 (Ad5) vector vaccine against Ad5[E1-, E2b]-Her2/neu that is effective in stimulating cell-mediated immunity (CMI) in animals previously i
mmune to Ad5. The Ad5[E1-, E2b-]- Her2/neu… more
Abstract:DESCRIPTION (provided by applicant): Current generation Adenovirus (Ad) vector vaccines deleted at the E1 or the E1, E3 regions have resulted in experimental potential to immunize against a variety of infectious diseases such as HIV. These Ad vectors permi
t the delivery of genes, which express… more
Abstract:DESCRIPTION (provided by applicant): The objective of this project is to continue to develop an adenoviral vector vaccine against CEA that is effective in stimulating cell-mediated immune responses in subjects previously immune to Adenovirus. The Ad-CEA v
accine endpoint is to treat patients with… more
Abstract:DESCRIPTION (provided by applicant): Many recent studies have demonstrated the efficacy of interstitial ablative approaches for the treatment of hepatic tumors, including chemical ablation, cryoablation, and thermal ablation using energy sources like RF, l
aser, microwave, or focused ultrasound.… more
Abstract:New methods and technology to rapidly characterize UHTC creep are necessary to fully understand and exploit their high temperature properties for hypersonic vehicles and rocket nozzles. Recently, the University of Michigan has developed a rapid, table top apparatus for characterizing the oxidation… more
Abstract:New composite manufacturing technology is urgently needed to improve rotocraft (and non-rotocraft) performance via further integration of composite materials. Recently, Advanced Ceramics Manufacturing (ACM) developed a system of water soluble composites tooling materials that has potential to… more
Abstract:DESCRIPTION (provided by applicant): In the past decade effective therapies have been developed for diabetic retinopathy (DR), but all too many diabetics who are at high risk for developing the more advanced stages of diabetic retinopathy fail to get even
the annual eye exams recommended by AAO,… more
Abstract:This project will focus on research and development to provide individuals with visual impairments a clothing-based platform that supports the function of existing Global Positioning Systems (GPS) way finding systems. The clothing platform will lead to the integration of GPS way finding… more
Abstract:An inherently rugged Universal Oscillator (UO) is needed to enable a superior class of configurable communications for NASA applications. The requirements are a low phase noise RF output concurrently with a rugged, reliable, small, power efficient, and frequency tuning ability. VIDA Products has… more
Abstract:The anytime-cognition SBIR effort will identify promising software architecture and algorithms for designing a human-machine system that improves distributed collaborative decision making in network centric environments. A survey of available techniques and technologies will be performed to… more
Abstract:This proposal exploits nano-materials to achieve exceptionally high energy in an 18650-size cell. The successful development of this cell will provide the Army with the highest energy density cell commercially available for years to come. This advancement in the cell capacity will lift military… more
Abstract:Given that the earth is more than 70% covered by water, the potential for converting these renewable resources to electricity is many times that of other resources. In the conversion of wave and water-current energy to electrical energy, gears are used as a convenient way to convert the slow-speed,… more
Abstract:Yields and operability of high performance infrared focal plane arrays (IRFPAs), particularly those fabricated in HgCdTe, are severely impacted by material defects introduced during growth and/or processing. Amethyst Wafer Mapping (AWM) is a materials characterization technology which when fully… more
Abstract:Type II strained layer superlattice (SLS) p-n diode arrays fabricated on domestic-source GaSb substrates are a promising route to meet the critical need within DoD for large area, large format array infrared detectors. However, current SLS material quality is limiting detector performance. A… more
Abstract:DESCRIPTION (provided by applicant): Advances in treatment strategies have increased the long-term survival of children with acute lymphoblastic leukemia (ALL). However, the outlook of infants with ALL remains dismal with long-term survival rates of only 3
0-50%. Therefore, new treatments are… more
Abstract:DESCRIPTION (provided by applicant): One of the major problems in the fight against cancer is the intrinsic or acquired resistance of tumors to current cancer treatments, particularly that associated with multidrug transporters (MDT; e.g. P-glycoprotein (P
-gp) and the multidrug associated protein… more
Abstract:DESCRIPTION (provided by applicant): Systemic treatment with the bacterial flagellin protein, a Toll-like receptor 5 (TLR5) agonist, provides protection against high dose radiation through activation of nuclear factor-(B (NF-(B). NF-(B signaling induces mu
ltiple factors that contribute to cell… more
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