Abstract:DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for treatment of acute myocardial infarction. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics
approach, we have successfully engineered… more
Abstract:DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy to prevent or reduce ischemia-reperfusion injury during lung transplantation. The enzyme strongly preserves vascular integrity and inhibits platelet activation and agg
regation without increasing bleeding risk.… more
Abstract:This Small Business Innovation Research (SBIR) Phase 1 proposal to the Department of Defense plans to demonstrate a design of 2 kW modular contaminant resistant high power density fuel cell power system using logistic fuel reformate as the fuel. TreadStone will develop a lightweight fuel cell stacks… more
Abstract:The use of coal, an abundant and economical energy source, to produce a clean hydrogen fuel with near-zero emission would reduce our reliance on imported oil and enhance our energy security. A membrane system that can consolidate the hydrogen production process is the most economical approach to… more
Abstract:Large Scale Training exercises such as the Fleet Synthetic Training - Joint (FST-J) demand incredible resources and effective planning. Prioritization of training events cannot guarantee that every training objective for every trainee can be met, particularly in environments where participants are… more
Abstract:Irregular warfare is increasingly the dominant form of military engagement. It is dynamic and unforgiving of errors, requiring warfighters to adapt fluidly to novel, complex, and ill-defined problems. The goal of this STTR is to define, prototype and (in Phase II) develop a training tool that builds… more
Abstract:While on deployment, many military surgeons spend the bulk of their time performing general and/or trauma surgery. With combat deployments averaging 12-18 months, such prolonged lapses in practice can degrade the surgeons' specialized knowledge and skills. This becomes a major problem upon their… more
Abstract:In Stability, Security, Transition, and Reconstruction (SSTR) operations, personnel from different agencies must effectively collaborate despite having different agendas, standard operating procedures, and desired outcomes. Even in SSTR operations, which are fundamentally collaborative, experts in… more
Abstract:The runway safety issue has been on the Most Wanted list of the National Transportation Safety Board since the list's inception in 1990. The FAA has responded by implementing two ground surveillance technologies at major U.S. airports to reduce the risk of runway incursions. However, both… more
Abstract:Aptima is proposing an innovative approach to developing relevant, effective military cultural training. The Cultural Awareness for Military Operations (CAMO) proof-of-concept prototype will be based on theoretically grounded and empirically validated pedagogy. It will result in a serious game built… more
Abstract:This SBIR topic presents two challenges. The first is to define techniques and technologies that advance the science of Accelerated Learning. The solution must be generalizable across complex problem domains. The second challenge is to apply this solution to the problem of insider threats to DoD… more
Abstract:Unofficial means of communication, such as internet blogs and forums and word-of-mouth contacts, provide an ideal medium for the spread of ideas within a society. While many of these topics are benign or even beneficial to the population, there are messages which have dangerous and destructive… more
Abstract:Army leaders face a wide variety of emotionally charged situations. Success in dealing with these situations requires that Army leaders manage their emotions and those of others. Army leaders, however, receive relatively little training in this area. Ne
Abstract:Across the services, warfighters are expected to rapidly master new knowledge and skills, spanning a wide variety of domains, from motor to cognitive. Traditional training systems generally lack the capability to apply adaptive training strategies that mi
Abstract:The limitations of current airspace management have necessitated the planning and development of the Next Generation Air Transportation System (NextGen). NextGen seeks to change the fundamental structure of airspace management to increase the safety and efficiency of flight operations. This effort… more
Abstract:Intelligence, Surveillance and Reconnaissance (ISR) systems are becoming more and more complex, with ever increasing fidelity of data and ever increasing numbers of deployable UAVs and other sensors. Error rates are currently the best predictor of performance in autonomous, human, and… more
Abstract:A key challenge for net-centric warfare in the age of information is: How do we know that our actions are having the desired effects? This deceptively simple question often goes unanswered despite the increasingly massive amounts of information available. In the Air and Space Operations Center… more
Abstract:To succeed against superior resources and technology, modern adversaries typically adopt asymmetric tactics to wage unconventional warfare. Current adversaries organize activities through small covert groups based primarily on existing relationships among family and friends. Identifying the networks… more
Abstract:Coordination and collaboration tools have become more sophisticated, allowing distributed collaboration to occur between operational centers and forward-deployed Special Operations units. With distributed, asynchronous collaboration, however, the opportunity for uncertainty in team… more
Abstract:Problem: Marines in the field rely heavily on their ability to survey the human landscape for potential insurgents and other individuals of interest. To support this activity, the Marines"Combat Hunter program trains behavioral"profiling", a set of skills used by military and civilian… more
Abstract:As technology advances, the number and types of virtual training environments that training designers and acquisition professionals have to select from is exponentially growing. Reaching high levels of skill requires novel approaches to training (DoD, 2004) to ensure that training resources are… more
Abstract:A key challenge to the future deployment of DARPA's Chemical Robots (ChemBots) ChemBots is a system for controlling them that operates in a distributed fashion. There are three primary requirements: 1) its distributed nature must be transparent to the user; 2) it must exploit local acting and… more
Abstract:Environmental management of at-risk sites requires decision-makers to integrate heterogeneous technical information with stakeholder values. Current models exist to specifically address the technical or numerical environmental conditions, and separately to provide decision analysis. A comprehensive… more
Abstract:All Soldiers are required to master 17 First Aid procedures in basic training. These 17 procedures are described in 99 pages of the Soldiers' Manual of Common Tasks. To even the best student, recall of these exact procedures in a stressful situation would be challenging. This proposal outlines a… more
Abstract:The space domain presents a deluge of disparate data overloading analysts to the point where critical information can be missed. The abundance of data heightens the appeal of information fusion solutions. In general, sensor fusion approaches can be viewed as bottom-up and driven by technical… more
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