Abstract:DESCRIPTION (provided by applicant): Lung fibrosis, a group of incurable lung diseases with high mortality rates, is characterized by inflammatory cell infiltration, fibroblast proliferation, and excessive deposition of extracellular matrix proteins (ECM)
in lung parenchyma. Globally, five million… more
Abstract:DESCRIPTION (provided by applicant): A major instigator of radiation-induced pathology is cellular damage caused by reactive oxygen species formed in the first moments after exposure. Most therapeutic agents are free radical scavengers which must be presen
t in high concentrations as exposure occurs… more
Abstract:Exposure to light at critical phases of the circadian cycle is the main stimulus that entrains circadian rhythms. Previous work has concluded that exposure of humans to bright light for an hour or more at the right phase of the circadian cycle produces significant phase shifts of circadian rhythms… more
Abstract:DESCRIPTION (provided by applicant): Cancers that are typically diagnosed as late-stage, metastatic disease, such as pancreatic cancer, have remained refractory to standard radiation, surgical and chemotherapy. With all the advance of newer more targeted a
gents, pancreatic cancer 5-year mortality… more
Abstract:DESCRIPTION (provided by applicant): We propose to identify an optimal short carbon chain lipid species to be used as a surrogate for membranes in a novel and improved blood coagulation factor assays that will improve rapid diagnosis of coagulation disorde
rs. Blood coagulation protects the… more
Abstract:AVEC proposes an innovative concept for the evaluation of human response studies to sonic booms inside realistic structures. The approach proposed is to simulate the distributed boom load on the structure using an array of discrete forces. The forces are applied sequentially making the approach… more
Abstract:EVA radio is an important integral part of lunar missions and beyond. To minimize power consumption and mass of an EVA radio, innovative solutions are needed for the design of various modules ranging from RF front end to networking protocols. In this protocol, a comprehensive design architecture… more
Abstract:Innovative network architecture, protocols, and algorithms are proposed for both lunar surface networks and orbit access networks. Firstly, an overlaying architecture is proposed to seamlessly integrate lunar surface networks and orbit access networks. Secondly, for lunar surface networks, a network… more
Abstract:By combining modern design techniques, such as design of experiments (DOE) with response surface models (RSM), as well as SOA electrical motor technology, the flow rates and efficiency requested by this solicitation can be achieved and surpassed. The DOE
Abstract:The focus of this SBIR project for the Missile Defense Agency (MDA) is the aftermath of a successful missile intercept, where the resulting fragments fall toward land or sea. The Phase I effort was successful in the development of tools and processes to predict the lift and drag of irregularly… more
Abstract:AVID proposes to develop software that determines takeoff and landing operational parameters for advanced military aircraft which result in trajectories that reduce noise in populated areas surrounding military airfields. This software will utilize GIS technologies to make teh analysis site-specific… more
Abstract:AVID proposes to develop solid-state morphing control surface actuation technology. By solid-state, we imply that there are no servos, linkages, or moving parts other than the conformal shape change of the aerodynamic surfaces. Instead, piezoelectric Macro Fiber Composites (MFC) will be used to… more
Abstract:AVID will develop an integrated analysis and design suite for flapping wing MAVs. Such a tool fills a void present in the existing MAV development process. It will enable rigorous multi-disciplinary engineering analysis and design optimization before construction. In this way, deeper understanding… more
Abstract:DESCRIPTION (provided by applicant): Our overall Goal is to develop our bactericidal R-type pyocin targeting E.coli O157:H7, as a specific therapeutic against infection and contamination. Enterohemorrhagic E. coli (EHEC) are a group of food- and waterborne
pathogens that cause illnesses ranging… more
Abstract:DESCRIPTION (provided by applicant): In our Phase 1 project we have developed R-type pyocins, targetable bactericidal proteins, that kill the plague bacterium, Yersinia pestis, in vitro and are not sensitive to the mechanisms that bacteria use to resist an
tibiotics. Thus, these agents are… more
Abstract:This Portable Multimodal Biometric Device (PMBD) will provide an integrated capability to employ individual-oriented identity information in the conduct of maritime and expeditionary operations. It will rapidly establish and verify the identity information of unknown individuals encountered in the… more
Abstract:DESCRIPTION (provided by applicant): The proposed study utilizes novel electronics and microfabrication techniques to create a non-invasive, automated platform for targeted monitoring and manipulation of human neural tissue. This research will enable rapid
advancements in both basic research and… more
Abstract:DESCRIPTION (provided by applicant): Sexual dysfunction is one of the most prevalent and persistent problems after cancer treatment. This Fast Track STTR will create and evaluate a multimedia educational and counseling tool to promote recovery of sexual sa
tisfaction in men treated for cancer.… more
Abstract:In this Phase 2 SBIR program submitted to National Aeronautics and Space Administration (NASA) in response to Topic S1.05 (Detector Technologies for UV, X-Ray, Gamma-Ray and Cosmic-Ray Instruments), Aymont Technology, Inc. (Aymont) and GE Global Research will enable high-sensitivity ultraviolet… more
Abstract:In the proposed Phase I SBIR program, Aymont Technology and CoolCAD Electronics will design and demonstrate prototype silicon carbide (SiC) avalanche photodiodes (APD) specifically designed for high-efficiency, single-photon counting of 121.6 nm Lyman-alpha photons. This detector will be provided to… more
Abstract:DESCRIPTION (provided by applicant): A Potential New Drug for Depression, an active SBIR Phase IIa award. The requested funds will allow additional characterization studies of three newly discovered mixed vasopressin 1a/1b antagonists, studies that were not part of the original application. These… more
Abstract:Historically, portable biometric collection systems have been designed for fixed Law Enforcement office applications. Their limitations stem from the fact that they were designed for specific hardware collection sensors optimized for a specific application. To a large extent the software is… more
Abstract:Azure Summit Technology will develop algorithms and techniques for Vector Navigation (VNAV) in this Phase I effort. Using actual collected GPS signals from a degraded RF environment, we will establish feasibility of VNAV through modeling and simulation. We will also develop a plan for a real time… more
Abstract:Next generation Radars (NGR) for MDA will advance closer to the ideal of a fully digitized array and digital beamforming. In a conventional phased array radar (PAR), analog beamforming networks reduce the entire array into a few combined beams (e.g., sum beam, difference beams) at X-band. Next… more
Abstract:In this Phase I effort, Azure Summit will develop a modular and scalable systems concept for SUAV payloads to perform RF Geolocation of broad classes of radar and communications emitters from 100-18000 MHz, across payload SWAP ranges, number of sensors, and signal environments, maximizing hardware… more
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