Abstract:DESCRIPTION (provided by applicant): Current LoCs are assay-specific and are custom-built for each single experiment. Performing an experiment requires life scientists to endure the time-consuming process of designing, fabricating, and testing a chip befor
e conducting the actual experiment. This… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project addresses the challenge of achieving variable volume fluid mixing at the microfluidic scale in the context of general-purpose programmable lab-on-a-chip devices (GPLoCs). Directly supporting variable volume mixing is fundamental to… more
Abstract:DESCRIPTION (provided by applicant): Sickle cell disease (SCD) is a hereditary blood disorder, affecting over 75,000 people in the United States and millions of people worldwide. In the US, those with SCD have an average mortality in their 40s, a poor qual
ity of life and high medical costs. In SCD,… more
Abstract:DESCRIPTION (provided by applicant): In this phase I, Koronis Biomedical Technology Corporation (KBT) proposes to develop and evaluate a prototype device that provides non-invasive, real-time intracranial pressure (ICP) monitoring. The proposed device will
measure ICP with the simplicity of a… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technologies (KBT) proposes to develop a wireless implantable dosimeter with the ability to track both location and orientation in real-time by combining radiation sensitive field- effect-device (RADF
ET) technology together with… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technology Corporation (KBT) proposes to develop an indoor wayfinding device utilizing a novel indoor location technology based on magnetic anomaly detection, and augmented with inertial dead-reckonin
g technology. Unique magnetic anomaly… more
Abstract:The proposed innovation is a methodology to incorporate variable fidelity structural models into steady and unsteady aeroelastic and aeroservoelastic analyses in order to utilize the appropriate level of fidelity for the problem at hand. Some aeroelastic problems require detailed finite element… more
Abstract:DESCRIPTION (provided by applicant): Clinical diagnostic laboratories determine the presence, or absence, of viruses, parasites, bacteria, or fungi in biological specimens submitted under physicians' order for testing. The medical field has estimated that
over 70% of all health care decisions are… more
Abstract:Large deployable telescopes such as NASA's 9.2m and 16.8m segmented ATLAST systems require commensurately large deployable sunshades for thermal control and to prevent stray light from contaminating the desired science images. Existing deployable structures technologies are too heavy and… more
Abstract:One of the goals of NASA's Fundamental Aeronautics "Subsonic Fixed Wing" project is to reduce fuel burn by 25% 5% by 2018. This corresponds approximately to an increase in Lift/Drag ratio of the same magnitude. While the improvement in design tools funded by NASA will undoubtedly help attain this… more
Abstract:DESCRIPTION (provided by applicant): Chronic total occlusions (CTOs), defined as vessels that have been completely occluded for 3 months, are a prevalent vascular disease found in about one-third of patients undergoing a coronary angiogram and in 30-50% of
peripheral procedures. Revascularization… more
Abstract:The devastating traumatic injuries sustained by warfighters in OIF/OEF frequently involve the loss of large portions of bone, muscle and skin. Current management of tissue coverage and augmentation involves the use of existing host tissue to construct, for example, muscular flaps or grafts. In many… more
Abstract:In Phase I we propose to demonstrate a room temperature continuous wave QC laser at 4.5m with high power (P>0.5W) and wall plug efficiency (η>5%). The data will be used to design a high performance QC laser with projected wall plug efficiency exceeding 15% in continuous mode operation at room… more
Abstract:DESCRIPTION (provided by applicant): With the increasing requirements for assuming prominent disease management and preventive screening activities, primary care physicians find themselves lacking cost-effective resources to improve the quality of medical
care they provide to patients with chronic… more
Abstract:DESCRIPTION (provided by applicant): The goal of the Enhanced Medication Management Program (eMMp) being developed by MedMinder Systems, Inc. is to increase the ability of frail elders to adhere to complex medication regimens for chronic conditions. Ad
herence will facilitate effective self-care… more
Abstract:DESCRIPTION (provided by applicant): This proposal addresses PHS 2009-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]). Hypertrophic scars commonly form during healing of
deep dermal wounds and are characterized… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this project is to create an efficient, unique, and versatile laser instrument that will have applications in a large range of surgical procedures including dermatology, laryngology, otology, and o
phthalmology. In the near-term, these… more
Abstract:DESCRIPTION (provided by applicant): Innovative products that reduce the costs and increase the quality and productivity of drug discovery research are more important than ever. We will rigorously validate prototypes of compound management products that wi
ll help overcome limitations in the field… more
Abstract:We propose to engage with all stakeholders (administrative, policy and decision makers, data providers, users of the system, technology developers) and survey the resources, opportunities, barriers and challenges and risks involved through a systematic process of "Solution Envisioning" in order to… more
Abstract:We propose a Semantic Web based Ontology Engine to map disparate medical terminologies to help patient management, and pharmacovigilance efforts with emphasis on TBI and PTSD patients. Currently, there are multiple terminologies being used both within and outside the MHS. The proposed system and… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this work is to produce a wearable continuous alcohol monitor that is pain- free and noninvasive, with wireless communications capability to enable remote monitoring. The monitor centers around a nov
el biosensor consisting of a multi-well… more
Abstract:DESCRIPTION (provided by applicant): Vitamin D plays a critical role in calcium metabolism and bone health in children and adults. It is now recognized that every tissue and cell in the body have a vitamin D receptor and thus every tissue and cell in the b
ody is a target for vitamin D action.… more
Abstract:DESCRIPTION (provided by applicant): Carbonix LLC proposes a Phase I research program on its novel process that abates indoor allergenic proteins that are implicated in allergies and asthma attacks. Common allergenic proteins are produced, for example, by
household dust mites and cats. It is… more
Abstract:Manufacture and maintenance of aircraft, ships, light rail cars, etc., requires many structural components formed out of extrusions. Processes such as stretch forming are typically used to produce these parts, in which unique dies are required for each forming operation. This increases the cost… more
Abstract:DESCRIPTION (provided by applicant): To meet the Agency's requirement for rapid, precise and on-site measurement of emerging contaminants such as fire retardant chemical PBDEs, critical technologies must be developed where upon mixing a reagent and a detec
tion target, a signal is generated without… more
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