Abstract:US forces are increasingly involved in asymmetric warfare, peacekeeping and humanitarian assistance missions. These scenarios can place soldiers in direct contact with harmful biological and chemical warfare organisms and agents, toxic industrial chemicals, and explosives. Current portable sensor… more
Abstract:We will develop novel acousto-optic devices for use in the UV using the new material Barium Borate (BBO) which not only has the required UV transparency, but a unique combination of acoustic and optical properties. The capabilities provided by these new UV AO devices are ideally suited for optical… more
Abstract:Presently, there is an increase in the need for materials that exhibit strong nonlinear absorption materials for various military applications. In addition to the non-linear optical properties, materials with the following characteristics are desired: variable bandgap, a cut-on wavelength of 0.4… more
Abstract:Sensor development researchers and engineers have perpetually sought novel methods to reduce sensor size and improve performance. Continued miniaturization of sensors through micromachining has enabled novel applications and introduced new paradigms for engineered systems to interact with the world… more
Abstract:We propose to develop a computational model of leadership designed to capture complex variables including cultural differences in leadership requirements along with task differences, primarily ill-defined goals, which pose leadership challenges. Rather than avoiding these kinds of complexity and… more
Abstract:The technical objectives of this proposal are: 1) the design of 8 micron-emitting active-photonic-crystal (APC) quantum-cascade (QC) lasers by using passive phase-locking in a monolithic structure in order to achieve multiwatt-range, diffraction-limited powers; and 2) the development of the key… more
Abstract:DESCRIPTION (provided by applicant): Cancer progenitor cell markers Phase I/II Fast-Track application In response to RFA-CA-08-011 Innovative and Applied Molecular Analysis Technologies for Cancer (SBIR [R43/R44]) Circulating tumor cells (CTCs) have b
een identified in peripheral blood from… more
Abstract:DESCRIPTION (provided by applicant): Secondary metabolites will be extracted from a specific plant material to identify and isolate immune active components. These components are proposed to enhance the innate and adaptive immune systems by modulating cert
ain cytokine levels in white blood cells… more
Abstract:The goal of this project is to develop STC trastuzumab, a generic version of Herceptin. Trastuzumab is a monoclonal antibody made against the HER2 protein that is overexpressed in 20-25% of patients with breast cancer. Because of very high cost associated with prescribing Herceptin, a generic… more
Abstract:DESCRIPTION (provided by applicant): HeartRate Games' objective is to speed the pace of fitness games innovation by giving developers a set of technology tools that make it easier to create great products combining fitness games with the proven benefits of
cardio exercise machines. Fitness games… more
Abstract:DESCRIPTION (provided by applicant): To establish the proof of concept that Nutrabiotix fiber is safe and well tolerated, promotes gut health by increasing production of short chain fatty acids and changes colonic microbiota composition in favor of bifidob
acteria, improves bowel habit and increase… more
Abstract:DESCRIPTION (provided by applicant): Project Summary The broad long term goal of this research program is to reduce or eliminate deafness by developing sustained release intracochlear drug delivery systems. The goal of this project is to develop a ster
oid eluting cochlear implant. Currently,… more
Abstract:'This project was funded as a Phase I contract by the NCI Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Program in response to funding announcement number 272 "Point of Care Analysis of Circulating Tumor Cells for Cancer Diagnostics, Prognosis, and… more
Abstract:DESCRIPTION (provided by applicant): This research is to study the feasibility of an in-home tonometer based on the two color strobe technology (TCST) developed by CeeMaxTM Ophthalmic, a division of Achevi Technology. We are the manufacturer of ophthalmic
diagnostic instruments with core expertise… more
Abstract:DESCRIPTION (provided by applicant): DNAnexus proposes to develop a complete solution for the identification and stratification of personal genetic variation from ultra-high-throughput sequencing projects. The solution will be implemented as a Web 2.0 serv
ice and online browsing tool that will… more
Abstract:DESCRIPTION (provided by applicant): Diabetes costs the United States an estimated 174 billion annually. About two-thirds of costs arise from direct medical expenditures, and the remainder accrues from disability, work loss, and premature mortality. Assoc
iated cardiovascular comorbidities result… more
Abstract:DESCRIPTION (provided by applicant): The feasibility of a label-free technology, Millikan Sequencing, will be evaluated for de novo sequencing of mammalian genomes for under 1,000. This novel sequencing-by-synthesis approach measures the increased charg
e as nucleotides are added to DNA templates… more
Abstract:DESCRIPTION (provided by applicant): The occurrence of obesity is increasingly growing, and it has been projected that 40% of the US population will be obese by the year 2025. The World Health Organization estimates over 1.6 billion adults (age 15+) are ov
erweight, and at least 400 million are… more
Abstract:DESCRIPTION (provided by applicant): This overall goal of this project is to develop a scalable process for fabricating oil encapsulated particles with uniform sizes and physical characteristics that contain oil as a vehicle for delivering hydrophobic drug
s. Poorly water soluble active… more
Abstract:Currently, wide area coverage with manned aircraft, or existing UAS, requires expensive logistical operations and many flight sorties, which are made especially difficult if operating from remote airfields in inhospitable climates. There is currently a need for a low-altitude long endurance unmanned… more
Abstract:DESCRIPTION (provided by applicant): Ostene is a soft, synthetic, moldable hemostatic material that sticks well to cut bone surfaces and stops bleeding by mechanical occlusion. Ostene is a combination of biocompatible water-soluble polymers which are absor
bed completely within 24 to 48 hours of… more
Abstract:DESCRIPTION (provided by applicant): Type 2 diabetes (T2DM) is a chronic metabolic disease that affects the quality and longevity of life. Currently it is estimated that about 246 million people worldwide and diabetic and their number is expected to increa
se to 380 million by 2025. Further, the… more
Abstract:DESCRIPTION (provided by applicant): Although the existing agents for treating cancer have shown promising results, the inherent genetic plasticity of the cancer cells continues to undermine the efficacy of these treatments. One of the possible solutions t
o address this problem is to attack the… more
Abstract:DESCRIPTION (provided by applicant): Most next-generation DNA sequencing methods have focused on either 1) template amplification followed by massively-parallel sequencing-by-synthesis, or 2) single molecule detection. The first method is now commercially
available but suffers from relatively… more
Abstract:DESCRIPTION (provided by applicant): The proposed research is directed at designing and demonstrating a compact, cost-effective high-frequency, tunable 2nd-harmonic gyrotron for Dynamic Nuclear Polarization (DNP) enhanced solid-state Nuclear Magnetic Reson
ance (SSNMR) spectroscopy at 600 MHz. With… more
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