Abstract:DESCRIPTION (provided by applicant): To meet the Agency's requirement for rapid, precise and on-site measurement of emerging contaminants such as fire retardant chemical PBDEs, critical technologies must be developed where upon mixing a reagent and a detec
tion target, a signal is generated without… more
Abstract:A key application of the technological breakthrough associated with decreased cost of DNA sequencing is metagenomics. Metagenomics is the process of sequencing DNA from whole ecosystems, rather than individuals or cultures. This approach has the potential to allow the dissection of microbial… more
Abstract:A completely automatic, cost-effective, production of garments and other sewn items can be achieved. A novel approach that depends heavily on computing, high performance servo systems, and machine vision has been demonstrated. This proposal will lead to a the most critical element of such… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of Mynosys Cellular Devices is to develop new semi-robotic microdevices that enable scientists to directly physically probe or manipulate individual neurons or subcellular processes for a variet
y of experimental and therapeutic purposes.… more
Abstract:DESCRIPTION (provided by applicant): The present lack of blood-based diagnosis requires AD patients to be subjected to either invasive spinal fluid (CSF) tapping, expensive MRI or PET imaging, or arduous psychological testing, all unsuitable and costly for
our elderly. Strategically, we shall… more
Abstract:DESCRIPTION (provided by applicant): This proposal seeks to develop a specific and efficient means to reduce or eliminate the production of the progerin protein, the cause of the premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS). A de no
vo point mutation in codon 608 of the lamin… more
Abstract:DESCRIPTION (provided by applicant): Kidney stones are a common and painful human health care problem worldwide. Of all stones developed approximately 70% are composed of calcium oxalate. Urinary oxalate is regarded as a driving force for calcium oxalate s
tone formation, and absorption of dietary… more
Abstract:DESCRIPTION (provided by applicant): Severe diseases or conditions such as primary hyperoxaluria (PH), secondary hyperoxaluria (SH), and Zellweger spectrum disorders (ZSD) continues to be a healthcare problem. These diseases occur when oxalate is readily a
bsorbed from dietary sources or from liver… more
Abstract:DESCRIPTION (provided by applicant): This Phase I Small Business Innovation Research proposal is in response to RFA-AT- 09-004 Translational Tools for Clinical Studies of CAM Interventions. The proposed technology development and testing project integrates
three important capabilities into one… more
Abstract:DESCRIPTION (provided by applicant): Engineered tissues are revolutionizing disease therapy in many areas of medicine. It is estimated that the total market size for all types of tissue engineered therapies was 1.5 billion in 2008. But for many t
ypes of engineered tissues, including… more
Abstract:DESCRIPTION (provided by applicant): The Alzheimer's Association 2009 Alzheimer's Disease Facts and Figures report indicates that as many as 5.3 million Americans suffer from Alzheimer disease (AD), and it costs the country about 148 billion a year to pro
vide care. AD triples healthcare costs for… more
Abstract:DESCRIPTION (provided by applicant): The kidney is a target of toxicity from drugs, and industrial and environmental chemicals because of its high blood flow, numerous transporters, and reliance on aerobic metabolism. Not surprisingly, mitochondria are a c
ommon intracellular target of chemicals in… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project at Azano Pharmaceuticals, Inc. will help establish the technical and commercial feasibility of a novel treatment for systemic lupus erythematosus (SLE). SLE is a c
hronic inflammatory disease of humans that… more
Abstract:DESCRIPTION (provided by applicant): This Phase I SBIR application proposes the development and pilot testing of a health promotion mobile phone application, www.BodiMojo.mobi, for adolescents (ages 14-18). The product is designed to promote healthy eating
and physical activity in older adolescents… more
Abstract:The goal of the proposed study is to develop reagents for the optimal handling of pre-analytical biospecimen for use in biomarker discovery and biomedical research. The advent of molecular diagnostics and personalized medicine bears great promise for changing the field of medicine by enabling… more
Abstract:The injection and storage of captured CO2 in coal beds has been suggested as a strategy to reduce industrial emissions of CO2 into the atmosphere. The sequestration process involves the adsorption by coal of injected CO2 and an associated desorption of CH4 whose production can partially offset the… more
Abstract:DESCRIPTION (provided by applicant): The Patch Clamp technique has evolved in recent years from an esoteric method of basic electrophysiological research into properties of cell membranes, into a practical technique for mass screening compounds for potenti
ally therapeutic pharmaceutical properties.… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I project is the identification of a molecular signature in the T-cell receptor repertoire of early-stage Type 1 Diabetes (T1D) patients that distinguishes these patients from controls. At presen
t, immunomodulatory therapies have not… more
Abstract:DESCRIPTION (provided by applicant): The overall goals of the proposed phase 1 SBIR project are to investigate the in vivo efficacy and mechanism of action of a novel, first-in-class drug candidate for treating interstitial cystitis/painful bladder syndrom
e (IC/PBS). IC/PBS is a chronic and… more
Abstract:DESCRIPTION (provided by applicant): Improved iron chelators are required with the lifelong transfusion treatment of the genetic anemias, Sickle Cell Disease (SCD) and the Thalassemias (THL), because the regular blood transfusions, lead to accumulations of
toxic, sometime fatal amounts of iron that… more
Abstract:DESCRIPTION (provided by applicant): This is an application to test the efficacy of a new approach to cognitive training that is focused on higher level processes such as reasoning and inference. The proposal concerns content of interest to mature adults
. The product that will be developed out of… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this Phase I project is to create technical protocols for the reproducible operation of our proprietary cell-based device for the treatment of acute renal failure. The project specific aims are: (1)
To identify active therapeutic secreted… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes the development of a stem cell-based extracorporeal device that can offer unparalleled support to 200,000+ patients undergoing severe acute kidney injury annually. The device delivers cell-derived secretions of anti-inflammatory… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this application is to develop a scalable production system for the manufacture of an adeno- associated virus (AAV) serotype 8-based gene therapy vector bearing a human low density lipoprotein recept
or (hLDLR) transgene for the treatment of… more
Abstract:DESCRIPTION (provided by applicant): Bladder cancer is the fourth most common cancer among men and the seventh most common cancer in women with a life expectancy of only five years after diagnosis. Repair of the mid stage of this cancer requires excision o
f the diseased area. Surprisingly however,… more
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