Abstract:DESCRIPTION (provided by applicant): Natural products are still the majority of therapeutic agents. However, they suffer from a difficulty in the creation of derivatives, and they can also be hard to supply. Derivatives are extremely important in the optim
ization of properties, such as toxicity or… more
Abstract:The object of the proposed work is to develop better processes for the electrochemical conversion of CO2 into a high value chemical in a growing market. CO2 is one of the key causes of global warming. If we can recycle CO2 back into useful products, than the costs of meeting the Nation
Abstract:DESCRIPTION (provided by applicant): This project addresses the looming optical detection bottleneck in sequencing by developing an ultra high-throughput 250nm-scale optical scanner. In addition to a 50X gain in throughput, the approach also supports a 4X feature-size reduction path that can help… more
Abstract:DESCRIPTION (provided by applicant): This proposal will establish the feasibility of an innovative Synthetic Fascia(tm) for improved repair of abdominal wall hernias. The manufacture of Synthetic Fascia(tm) from engineered structural proteins will lead to
greater control over degradation and purity… more
Abstract:DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a leading aged-related neurodegenerative disorder afflicting millions of Americans currently. Clinical diagnosis of PD relies on the analysis of symptoms and signs, limited laboratory tests,
and more recently, functional neuroimaging.… more
Abstract:We developed a technology called PlatinDx that, based upon preclinical data, can potentially identify chemoresistance in cancer patients before they receive carboplatin or cisplatin therapy. PlatinDx utilizes tracing of subtherapeutic "microdoses" of 14C-labeled carboplatin with… more
Abstract:Nimbis Services Inc. proposes to provide a software portal hosting, distribution and access infrastructure integrated with Nimbis Services's current brokerage service that will broaden the use of digital analysis computing or model based simulation by tier 2-4 supply chain manufacturers. The goal… more
Abstract:DESCRIPTION (provided by applicant): Pulmonary arterial hypertension (PAH) is a rare disease associated with high morbidity and mortality. The purpose of this proposal is to develop a novel combined JAK1/JAK2 inhibitor or more selective JAK2 inhibitor for
PAH that will be delivered by inhalation.… more
Abstract:DESCRIPTION (provided by applicant): Pulmonary arterial hypertension (PAH) is a devastating disease associated with high morbidity and mortality. The purpose of this proposal is to develop a novel highly selective platelet derived growth factor receptor (P
DGFR) inhibitor for PAH that will be… more
Abstract:DESCRIPTION (provided by applicant): The twin epidemics of obesity and diabetes threaten to overwhelm healthcare systems in the U.S. and worldwide, with almost 29 million Americans currently having frank diabetes (predominantly type-2; T2DM) and an additio
nal 68 million with prediabetes. There is… more
Abstract:DESCRIPTION (provided by applicant): In the past three decades intraocular lens (IOL) replacement has become the standard of care for treating cataracts, the world's leading cause of blindness. Tremendous advances have been made both in the design of the I
OL and in the surgical procedure. The… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this initiative is to develop a novel technology for the expression of authentic glycoproteins. Many proteins become post-translationally modified during the secretory process. These modifications are ext
remely important because they may alter the… more
Abstract:DESCRIPTION (provided by applicant): Three ideas motivate this project. First, bioactive small molecules often act on multiple targets- sometimes this polypharmacology is key to their efficacy, sometimes it is the source of unwanted side-effects, rarely
is it entirely absent. Second, these… more
Abstract:DESCRIPTION (provided by applicant): Myometrics is in the early stages of developing a device consisting of a novel, non-protein osteogenic agent suspended in a collagen sponge that would be applied by the practitioner into the tooth socket following extra
ction for ultimate placement of dental… more
Abstract:DESCRIPTION (provided by applicant): Depression is one of the most common of the psychological disorders (Kessler, Berglund, Demler, Jin, and Walters, 2005; Kessler, Chiu, Demler, and Walters, 2005). For a variety of reasons, millions of Americans do not h
ave access to treatment, despite the… more
Abstract:DESCRIPTION (provided by applicant): Since the introduction of highly active antiretroviral therapy (HAART) in the mid-1990's for treatment of human immunodeficiency virus type 1 (HIV-1) infection, overall incidence rates of associated neurological maladi
es have declined. Unfortunately, the… more
Abstract:DESCRIPTION (provided by applicant): Recent advancements in photo-responsive molecules allowed neuroscientists to remotely control neuron activities by focusing light on individual cells. Because of the non-invasive nature of optical control, long term con
trol and monitoring of neurons for study of… more
Abstract:DESCRIPTION (provided by applicant): Targeted delivery of therapeutics has been a long-term goal in clinical medicine. Of particular interest is to be able to selectively target a drug to specific cells or tissues which could benefit from the drug activity
, and avoid delivery of the drug to other… more
Abstract:Different patients react very differently to chemotherapeutic cancer drugs, and are variably susceptible to drug side effects. Many patients are therefore currently not receiving adequate levels of those drugs. A personalized monitoring of toxic drug metabolites would greatly aid physicians to… more
Abstract:DESCRIPTION (provided by applicant): Dental caries (tooth decay), is the single most common chronic disease of childhood, affecting nearly 6 in 10 children in the United States. Poor oral health is epidemic among all children, but is especially severe amon
g lower income children. Untreated, tooth… more
Abstract:DESCRIPTION (provided by applicant): Quick-Set Endodontic Material Additions are shown in this new font. This project is to develop a dental material that sets in about 15 minutes, and is suitable for use in surgical or non-surgical endodontic procedures.
The material is intended to be an… more
Abstract:Proposed is a method and technology for implementing core functions of Database Translator (DATALATOR) for Integrated Exploitation in dynamic context of the urban warfighter. The focus is on providing tangible means for data users to be directly involved in meeting their operational objectives. The… more
Abstract:DESCRIPTION (provided by applicant): Dental implants are the fastest growing field in dentistry. However, high complication rates result in significant morbidity, cost, and disappointment. Better pre-operative knowledge of soft tissue thickness and hard ti
ssue contour could dramatically cut… more
Abstract:Ultrasound guidance procedures, such as central line placement and needle biopsy, require considerable skill to precisely position a needle or catheter while simultaneously holding a transducer. Finger-mounted ultrasound transducer array probes may potentially improve the workflow requirements of… more
Abstract:This project develops a system to provide augmentative sensory feedback in the lower limbs of amputees and diabetic/vascular patients by enhancing sensory function resulting in improved mobility and improved quality of life. The sensory feedback system detects force loads at the base of the foot… more
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