Abstract:New sensor technology is required to face the challenging tasks associated with future space exploration involving missions to the Moon and Mars. The safety and well-being of the crew critically depends on early detection of threats as well as maintaining stable and acceptable conditions in the crew… more
Abstract:This project targets the development of a highly sensitive gas sensor to monitor atmospheric nitrous oxide. Nitrous oxide is an important species in Earth science research. It is one of the four principal greenhouse gases that result from human activities. It is the primary source gas for nitrogen… more
Abstract:Isotope hydrology is a powerful method to trace transport and dispersion of contaminants in the subsurface. Although widely applied, the method depends on sample analysis in specialized laboratories equipped with expensive and complex analysis tools. Small, rugged analyzers suitable for on-site… more
Abstract:Although carbon dioxide remains the most cited greenhouse gas, other gases play important roles in climate change. Carbon monoxide measurements are probably the most important gas phase measurements to be performed in the field to track pollution, to fingerprint sources and to separate dynamics from… more
Abstract:Methane is considered the second most important greenhouse gas in the atmosphere. The relatively short lifetime makes it a candidate for mitigating global warming over the near-term. Highly sensitive measurement equipment is required to measure the low atmospheric concentrations with sufficient… more
Abstract:Improved production yield is a constant objective of increasingly sophisticated agricultural practices. As Earth's population grows, higher yield is a critical mechanism for insuring adequate food supply. An effective way to increase yield is by reducing waste. Crops begin to ripen when encountering… more
Abstract:Malaria caused by Plasmodium falciparum results in serious illness and, if untreated, often leads to death. Although a number of candidate vaccines have progressed to clinical trials the efficacy rate of those vaccines was much lower than ideal. New methods for simultaneous presentation and immune… more
Abstract:DESCRIPTION (provided by applicant): Abstract: The overall goal of this SBIR proposal is to develop and commercialize a new human liver bioassay system for real time, long-term toxicity analysis of chemical agents or drugs in vitro. At present, liver studi
es are mostly performed using hepatocytes… more
Abstract:DESCRIPTION (provided by applicant): The objective of this proposal is to assess the feasibility of using recombinant virus-like-particles (VLPs) to elicit neutralizing antibodies and prime CD4+/CD8+ T cells reactive with hepatitis B viral (HBV) antigens a
s candidate immunotherapeutics for chronic… more
Abstract:Breast cancer is a devastating affliction in Western Society. It is of high interest to quantify the expression of HER2/neu (a growth factor receptor), the estrogen receptor (ER), and the progesterone receptor (PR) in breast cancer tumors since HER2/neu expression is associated with… more
Abstract:The overall objective of this proposal is to preclinically develop VMD-1201 or a lead analog compound of a preferentially peripheral-acting PKC epsilon inhibitor as an oral targeted anticancer drug for treatment of human head and neck cancer with much reduced side effects. The long term goal of… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this SBIR project is to develop a new tool to improve the ability of blind and visually impaired people to quickly get to the right web pages, to avoid ending up on the wrong web pages, and to reach the d
esired part of the web page efficiently.… more
Abstract:DESCRIPTION (provided by applicant): Freezing of Gait (FOG) effects the majority of the approximately one million individuals who have Parkinson's disease nationwide and causes a cessation of movement that patients describe as feeling as if their feet areglued to the ground . FOG most often… more
Abstract:This Small Business Technology Transfer (STTR) Phase II project will advance the development and prototype testing necessary to transition an innovative large scale generating system from concept to commercialization. The underwater energy generation system is based on the naturally occurring… more
Abstract:Military applications for the use of directed electromagnetic energy, which include high power microwave (HPM), seek to disrupt electronic systems by exploiting non-linearity in semiconductors. While current mode second breakdown is a thermal non-linearity often exploited, it has been demonstrated… more
Abstract:Voss Scientific proposes an innovative methodology to determine the susceptibility of electronic systems to electromagnetic interference. Termed the Automated Susceptibility Test Architecture (ASTA), this novel adaptive approach will result in decreased test times and potentially discover unique… more
Abstract:There is a strong need to develop inexpensive and efficient pretreatment processes which can be used by the biofuel industry to make it economically viable. The process of converting to useful liquid fuel lignocellulosic biomass, which is available in abundant quantity, is hindered by the… more
Abstract:There is a need for a high-resolution two-dimensional focal plane array (FPA) with single photon sensitivity (SPS), pulse amplitude storage, and GHz bit rates that can record both the time (with 10 bits) from multiple returns from a single laser pulse. Such a system… more
Abstract:New, modular radiation hard [>300 kRad (Si)] ROIC designs are required to address the needs of planned ballistic missile defense system. Anticipating the needs for large formats, small pixel sizes, and multiple spectral bands, the features of an existing radiation-hard space imager ROIC will be used… more
Abstract:Future seekers of the future will need to allow for multiple targets and various advanced countermeasures, likely including a dual-mode component to do so. A Dual Mode Seeker (DMS) has at least an infrared (IR) Focal Plane Array (FPA) as well as an active means to capture target range and preferably… more
Abstract:A back-illuminated planar InGaAs photodiode tested to have 95% quantum effiiency (QE) at 1550 nm, area greater than 1 mm2, low capacitance (<23 pF), and high bandwidth (>125 MHz) will be improved. Although the existing Phase I device exhibited bulk material dark current generation better… more
Abstract:The capacity to integrate RF and free-space optical hybrid communications is now feasible given advances in adaptive optics and optical automated gain control. Proposed is a novel high-speed avalanche photodiode (APD) receiver, with over 5 GBPS data rates, and single-photon sensitivity. The APD… more
Abstract:Visible-transparent upconverting films consisting of lanthanide-doped metal-oxide nanocrystal (NC) quantum dots functionalized with near-infrared (NIR) and short-wavelength infrared (SWIR) sensitizers will be optimized for integration with polycarbonate optical elements. In Phase I, upconversion was… more
Abstract:A 128 x 128-format avalanche photodiode (APD) focal plane array (FPA), including a low-power dual-mode readout integrated circuit (ROIC) and low excess noise, high gain (M>1,200) will be developed for laser radar (LADAR) applications requiring reduced SWAP. The FPA gives LADAR seekers an advanced… more
Abstract:Current methods of growing carbon nanotubes (CNTs) of specific chirality yield mixtures of single-walled CNTs (SWNTs) with different structures and electronic properties, and methods to separate nanotubes by their electronic properties remain expensive and small-scale. Accordingly, synthesis today… more
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