Abstract:Methane is considered the second most important greenhouse gas in the atmosphere. The relatively short lifetime makes it a candidate for mitigating global warming over the near-term. Highly sensitive measurement equipment is required to measure the low atmospheric concentrations with sufficient… more
Abstract:Improved production yield is a constant objective of increasingly sophisticated agricultural practices. As Earth's population grows, higher yield is a critical mechanism for insuring adequate food supply. An effective way to increase yield is by reducing waste. Crops begin to ripen when encountering… more
Abstract:Malaria caused by Plasmodium falciparum results in serious illness and, if untreated, often leads to death. Although a number of candidate vaccines have progressed to clinical trials the efficacy rate of those vaccines was much lower than ideal. New methods for simultaneous presentation and immune… more
Abstract:DESCRIPTION (provided by applicant): Abstract: The overall goal of this SBIR proposal is to develop and commercialize a new human liver bioassay system for real time, long-term toxicity analysis of chemical agents or drugs in vitro. At present, liver studi
es are mostly performed using hepatocytes… more
Abstract:DESCRIPTION (provided by applicant): The objective of this proposal is to assess the feasibility of using recombinant virus-like-particles (VLPs) to elicit neutralizing antibodies and prime CD4+/CD8+ T cells reactive with hepatitis B viral (HBV) antigens a
s candidate immunotherapeutics for chronic… more
Abstract:Breast cancer is a devastating affliction in Western Society. It is of high interest to quantify the expression of HER2/neu (a growth factor receptor), the estrogen receptor (ER), and the progesterone receptor (PR) in breast cancer tumors since HER2/neu expression is associated with… more
Abstract:The overall objective of this proposal is to preclinically develop VMD-1201 or a lead analog compound of a preferentially peripheral-acting PKC epsilon inhibitor as an oral targeted anticancer drug for treatment of human head and neck cancer with much reduced side effects. The long term goal of… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this SBIR project is to develop a new tool to improve the ability of blind and visually impaired people to quickly get to the right web pages, to avoid ending up on the wrong web pages, and to reach the d
esired part of the web page efficiently.… more
Abstract:DESCRIPTION (provided by applicant): Freezing of Gait (FOG) effects the majority of the approximately one million individuals who have Parkinson's disease nationwide and causes a cessation of movement that patients describe as feeling as if their feet areglued to the ground . FOG most often… more
Abstract:This Small Business Technology Transfer (STTR) Phase II project will advance the development and prototype testing necessary to transition an innovative large scale generating system from concept to commercialization. The underwater energy generation system is based on the naturally occurring… more
Abstract:Military applications for the use of directed electromagnetic energy, which include high power microwave (HPM), seek to disrupt electronic systems by exploiting non-linearity in semiconductors. While current mode second breakdown is a thermal non-linearity often exploited, it has been demonstrated… more
Abstract:Voss Scientific proposes an innovative methodology to determine the susceptibility of electronic systems to electromagnetic interference. Termed the Automated Susceptibility Test Architecture (ASTA), this novel adaptive approach will result in decreased test times and potentially discover unique… more
Abstract:There is a strong need to develop inexpensive and efficient pretreatment processes which can be used by the biofuel industry to make it economically viable. The process of converting to useful liquid fuel lignocellulosic biomass, which is available in abundant quantity, is hindered by the… more
Abstract:There is a need for a high-resolution two-dimensional focal plane array (FPA) with single photon sensitivity (SPS), pulse amplitude storage, and GHz bit rates that can record both the time (with 10 bits) from multiple returns from a single laser pulse. Such a system… more
Abstract:New, modular radiation hard [>300 kRad (Si)] ROIC designs are required to address the needs of planned ballistic missile defense system. Anticipating the needs for large formats, small pixel sizes, and multiple spectral bands, the features of an existing radiation-hard space imager ROIC will be used… more
Abstract:Future seekers of the future will need to allow for multiple targets and various advanced countermeasures, likely including a dual-mode component to do so. A Dual Mode Seeker (DMS) has at least an infrared (IR) Focal Plane Array (FPA) as well as an active means to capture target range and preferably… more
Abstract:A back-illuminated planar InGaAs photodiode tested to have 95% quantum effiiency (QE) at 1550 nm, area greater than 1 mm2, low capacitance (<23 pF), and high bandwidth (>125 MHz) will be improved. Although the existing Phase I device exhibited bulk material dark current generation better… more
Abstract:The capacity to integrate RF and free-space optical hybrid communications is now feasible given advances in adaptive optics and optical automated gain control. Proposed is a novel high-speed avalanche photodiode (APD) receiver, with over 5 GBPS data rates, and single-photon sensitivity. The APD… more
Abstract:Visible-transparent upconverting films consisting of lanthanide-doped metal-oxide nanocrystal (NC) quantum dots functionalized with near-infrared (NIR) and short-wavelength infrared (SWIR) sensitizers will be optimized for integration with polycarbonate optical elements. In Phase I, upconversion was… more
Abstract:A 128 x 128-format avalanche photodiode (APD) focal plane array (FPA), including a low-power dual-mode readout integrated circuit (ROIC) and low excess noise, high gain (M>1,200) will be developed for laser radar (LADAR) applications requiring reduced SWAP. The FPA gives LADAR seekers an advanced… more
Abstract:Current methods of growing carbon nanotubes (CNTs) of specific chirality yield mixtures of single-walled CNTs (SWNTs) with different structures and electronic properties, and methods to separate nanotubes by their electronic properties remain expensive and small-scale. Accordingly, synthesis today… more
Abstract:There is a need for technologies that protect the health and welfare of the American people in a terrorist emergency by detecting acts of biological contamination. Of the chemical, biological, and explosive (CBE) agents, anthrax, smallpox, plague, ricin, botulinum toxin, toxic commercial… more
Abstract:For detection and neutralization of mines and other threats in the surf zone (SZ), a 3D imaging system will be developed with higher resolution and greater sensitivity than contemporary designs. Using circuits proven on existing designs, the readout integrated circuits (ROIC) of a small-pixel-size… more
Abstract:90087S09-II Expanding user demand for X-ray beamline time for science experiments in diverse fields necessitates expensive new beamlines, or the more efficient use of existing resources. Detectors that collect more data, with efficient on-chip and off-chip processing of the resulting data streams,… more
Abstract:Direct detector materials must exhibit several attributes including both good photon absorption properties and high charge collection, as well as low dark current and good uniformity. These are difficult to achieve in a single material. So far no photoconductor material has been found with… more
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