Abstract:The Numerical Technology Company and North Star Imaging (NSI) team in this project to develop and verify a Computed Tomography (CT) based technology for accurate three-dimensional measurement and characterization of fiber waviness (wrinkles) in fiberglass/epoxy and carbon/epoxy composite structures.… more
Abstract:The objective of this proposal is to develop innovative highly reliable High Power Optical Amplifier (HPOA) modules for optical satellite communications (SATCOM) operating over broad ranges of temperatures (i.e. from -40 to +80 0C) and of radiation environment (i.e. total dose of 300krads with a… more
Abstract:Active phased array radars are expensive and solid state power and low noise amplifiers are a major component of that expense. Sharing these amplifiers amongst many antenna elements is a strategy for reducing expense. However, in order to maintain independent phase control, the phase shifter and its… more
Abstract:DESCRIPTION (provided by applicant): Desirable drug ADME (Absorption, Disposition, Metabolism and Elimination) properties are key determinants of a drug's to safety and efficacy. Unfortunately, poor ADME and Toxicity attributes have caused more drug failur
es than any other factors. There is a… more
Abstract:Risks associated with possible medical events during space missions are challenging to identify and manage. Resources must be applied judiciously and risk must not be ignored. NASA's researchers need the capability to identify the risks that arise from the potential medical events, gather all of… more
Abstract:The proposed BMAIS System is a binocular helmet mounted imaging system that features dual short wave infrared (SWIR) cameras, an embedded image processor and dual electronic displays to present the imagery to the pilot. The system is designed to be light weight and with a component distribution to… more
Abstract:Several approaches to multi-target tracking using data from disparate sources are available as a point of departure for meeting the requirements of the ballistic missile defense system. Kalman filters (KF) represent the basic fusion approach geared towards tracking the 3D positions, velocities and… more
Abstract:This SBIR Phase I project will develop and demonstrate the feasibility of X-ray with or without UV-C treatment for inactivating, destroying, or otherwise reducing major wastewater contaminants. The investigators will also make preliminary determinations as to the effectiveness and comparative… more
Abstract:We have developed a robust, multimodal tactile sensing technology that has similar sensitivities and mechanical properties to the human fingertip. We will incorporate these sensing modules into a mechatronic anthropomorphic robot hand and develop computer software to perform exploratory behaviors… more
Abstract:DESCRIPTION (provided by applicant): Tactile feedback is essential for dexterous use of the hand. Physical therapists working to rehabilitate hands with neurological damage understand that tactile sensation is a key indicator of ultimate hand function. Ne
urophysiologists have identified that rapid… more
Abstract:Ground, vehicle and airborne-based GPS receivers are subject to a variety of natural and man-made interference. Environmental impairments such as reduced signal strength due to heavy foliage, multipath reflections due to obstacles such as tall buildings and mountains are more pronounced in… more
Abstract:Coherent Logix, Incorporated is leveraging significant previous and on-going investment in the massively parallel HyperX technology by investigating enhancements to the COTS HyperX hardware, application software, and tool flow to better support dynamically adaptive processing. The attributes build… more
Abstract:Coherent Logix, Incorporated (CLX) proposes the development of an integrated large format detector array and low-power, high performance HyperX parallel processor to increase the situational awareness capabilities of the modern warfighter. This system will combine the high bandwidth and glueless… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Technology Transfer Phase I project entitled Identification of novel therapeutics for tuberculosis combining cheminformatics, diverse databases and logic-based pathway analysis describes the development of software that will facilitate new… more
Abstract:DESCRIPTION (provided by applicant): Ischemia-reperfusion injury (IRI) occurs in organs when circulation is interrupted, causing ischemia, and then ischemic tissue is reperfused. This leads to a series of biologic consequences, resulting in edema and inflammation. IRI is a significant problem in… more
Abstract:DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of death worldwide. Current therapies for cardiovascular disease are associated with partial success, restricted access, delays, possible neurotoxicity and other important limitations. Our goal is to develop a novel… more
Abstract:DESCRIPTION (provided by applicant): HIV continues to be a major public health problem in the United States, but there has been limited penetration of HIV prevention services in many healthcare settings. Novel methods for seamlessly integrating HIV prevention into medical practice are needed. The… more
Abstract:DESCRIPTION (provided by applicant): In this proposal we lay out a comprehensive research plan to evaluate our passive vaccination strategies targeting Staphylococcus aureus/MRSA to prevent or treat infections associated with S. aureus/MRSA. With the emergence of highly antibiotic-resistant… more
Abstract:DESCRIPTION (provided by applicant): This Phase I proposal details the rationale and the research plan for the synthesis and characterization of a polymeric delivery system that will deliver two anticancer drugs with diverse mechanisms of action simultaneously into ovarian cancer cells. The delivery… more
Abstract:DESCRIPTION (provided by applicant): The liver is the site of many metabolic processes, including metabolism of xenobiotics such as pharmaceutical compounds. Drug metabolism is highly species specific and can vary significantly between individuals of the same species. To date no reliable… more
Abstract:DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the leading cause of chronic disability in the United States. A clinical goal in the treatment and prevention of OA is to develop replacement cartilage using tissue engineering (TE) technologies.Although TE cartilage presently lacks the… more
Abstract:DESCRIPTION (provided by applicant): Project Abstract: Most adults with access to the Internet have used it to search for health information, and half of these queries are for friends or family of the searcher. Unfortunately, access to the Internet varies by socioeconomic status, hence the well… more
Abstract:DESCRIPTION (provided by applicant): The long term objective of this project is to enable elderly persons to independently live within their own homes later into their lives with the assurance that their safety and well-being can be remotely monitored by health care professionals. A critical… more
Abstract:DESCRIPTION (provided by applicant): As elders age, they need increasing amounts of adaptive assistance and care from their caregivers- people who are often busy or remote. With the baby boomer generation preparing to retire, the sheer number of people whowill need support will far outstrip the… more
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