Abstract:DESCRIPTION (provided by applicant): Breast cancer is the second most common cancer among women. Roughly 190,000 women in the U.S. will be diagnosed with breast cancer in 2009, and 40,000 will die. The majority of breast cancers originate in the lobular or
ductal cells of the milk-producing glands.… more
Abstract:DESCRIPTION (provided by applicant): Obesity and Type 2 diabetes affect the lives of millions of people worldwide, add significantly to health-related expenditures, and are seemingly unmanageable health issues, since rates of occurrence are steadily increa
sing. In parallel with the increasing… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a ceramic nanofiltration membrane with highly uniform pores oriented perpendicularly to the membrane surface using DNA as a template in a silica sol-gel. This membrane will be optimized to perform molecular… more
Abstract:DESCRIPTION (provided by applicant): Our long term goal is to develop a safe, effective vaccine to prevent respiratory syncytial virus (RSV) disease. RSV is the leading cause of bronchiolitis, viral pneumonia, respiratory failure, and mechanical ventilatio
n in infants. It causes gt120,000 infant… more
Abstract:Ziva Corporation in collaboration with UCSB will assess the feasibility of developing a directly modulated polarization switching laser based on the Vertical Cavity Surface Emitting Laser (VCSEL) geometry with a 3dB frequency of at least 10 GHz. This will be a major breakthrough in the ability to… more
Abstract:Ziva Corporation proposes to develop and demonstrate an innovative ultra-wide field of view imaging system that incorporates foveated zoom capability and is fabricated without having multiple cameras, bulky gimbals, or large mechanically moving parts. Ziva has developed under IR&D a unique… more
Abstract:In this Phase SBIR II proposal, Ziva proposes to demonstrate a prototype large angle 2-D scanner featuring integrated imager stabilization with >10X lower SWaP (size, weight, power) compared to conventional technologies. This meso-hydraulic-based technology is unique in that: Large scan angles are… more
Abstract:OBJECTIVE: A prototype unit capable of detecting trace amounts of low-volatility chemicals from distances of 25+ meters. DESCRIPTION: The ability to detect trace chemicals from safe distances is critical. When those chemicals are low-volatility (as they are for many explosives), the difficulty of… more
Abstract:CFD-based design-oriented (DO) steady/unsteady aerodynamic analysis tools for Aeroelastic / Aeroservoelastic (AE/ASE) evaluation lag significantly behind other multidisciplinary design optimization (MDO) developments for flight vehicle design. In practically all studies to date involving… more
Abstract:ZONA Technology, Inc. (ZONA) proposes to develop an on-line flutter prediction tool for wind tunnel model using the parameter varying estimation (PVE) technique to ensure the safety of the flutter model as well as the wind tunnel system. This tool will be applied to rapidly evaluate parameters, such… more
Abstract:Multidisciplinary design and optimization (MDO) tools developed to perform multi-disciplinary analysis based on low fidelity computation methods have been used in aircraft conceptual design for decades. These tools have been proven very effective for simple problems and mostly have been developed… more
Abstract:ZONA Technology, Inc. (ZONA) proposes to develop an integrated flight dynamics simulation capability with nonlinear aeroelastic interactions by combining a flight dynamics model and an added-on nonlinear aeroelastic solver in a Simulink environment. This nonlinear aeroelastic solver is generated by… more
Abstract:An efficient and accurate software package named ZMGP (ZONA Multi-scale Gaskinetic/Particle simulation package) is proposed as a 3D tool to predict the lunar dust trajectory and crater formation process when a retro-rocket lands on the lunar surface. ZMGP has many special features including: 1, the… more
Abstract:Multidisciplinary design, analysis, and optimization (MDAO) tools today possess limited disciplines with little fidelity modeling capability. These tools are typically developed as a single large software application that performs analysis for all disciplines but has little or no capability to… more
Abstract:This SBIR Phase II project will develop a method to convert the byproduct glycerol to a value-added co-product, xylitol, thereby helping to reduce the costs associated with biodiesel production. The anticipated result is a scalable process capable of converting crude glycerol to xylitol in a single… more
Abstract:This Small Business Innovation Research Phase I project seeks to enhance the capability of an instrument for identifying and quantifying bio-molecules, cells, microbes, and their interactions. The goal of the project is to demonstrate the feasibility of a Surface Plasmon Resonance (SPR) biosensor… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will demonstrate the production of robust, versatile probes based on Bioluminescence Resonance Energy Transfer to Quantum Dots (BRET-Qdot
Abstract:There is a clear need to better define patient-specific treatment strategies for the use of both standard and novel therapies for treating multiple myeloma. Eutropics is uniquely positioned to improve therapy efficacy for multiple myeloma by using a proprietary assay that provides a novel… more
Abstract:DESCRIPTION (provided by applicant): The Bcl-2 family proteins are key effectors of cancers. Recent studies indicate that Myeloma cell factor-1 (Mcl-1), a member of this protein family, is a key regulator of lymphoid cancers including Multiple Myeloma (MM)
, Non-Hodgkin's Lymphoma (NHL), and other… more
Abstract:The Small Business Research and Development Enhancement Act of 1992 requires the agencies of the Public Health Service, Department of Health and Human Services and certain other federal agencies to reserve 2.5% of their current fiscal year extramural budgets for research or research and… more
Abstract:DESCRIPTION (provided by applicant): Metastatic bone cancer and multiple myeloma affects over 600,000 people every year in the United States and cause progressive bone destruction that results in severe pain, fractures, and the inability to walk. Patients
usually present with incapacitating pain… more
Abstract:Ultra High Temperature Ceramics (UHTC's) such as zirconium and hafnium diboride based composites are of particular interest for hypersonic leading edges due to their extreme refractoriness. Successful integration into hypersonic structures will require high strength / high temperature joints to… more
Abstract:A method of inducing non-contact creep deformation was demonstrated in ultra high temperature diborides via electro-magnetic forces. The Phase II effort will focus on refining the Electro-Magnetic Mechanical Apparatus to exhibit better control of test variables and have a higher degree of… more
Abstract:This Small Business Technology Transfer Phase I project seeks to develop biomimetic structures in engineering ceramics based on the damage-tolerant sea shell micro-architecture. Poor damage tolerance of engineering ceramics leads to catastrophic failure modes under stress, which restricts their… more
Abstract:The Phase I SBIR program was extremely successful in that we demonstrated the feasibility of using nano-composite cathodes of metal oxide and lithium iron phosphate to provide lithium-ion cells with high energy, high power, abuse tolerance, improved low temperature performance, and good cycle life,… more
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