Abstract:DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with a loss of dopaminergic nigrostriatal neurons. There are over 1.5 million PD patients in the US, with about 50,000 new patients each ye
ar. The cornerstone of symptomatic… more
Abstract:OBJECTIVE: New lower-cost technologies for hardening critical electronic systems and infrastructures against electromagnetic threats across the frequency spectrum from the various forms of the electromagnetic spectrum to the various emissions of electromagnetic spectrum (EM) (non nuclear and… more
Abstract:DESCRIPTION (provided by applicant): The alarming increase in incidence of infections caused by drug-resistant bacteria has created an urgent need for new antibacterial agents. We have discovered and optimized a novel class of antibiotics targeting PolC, t
he replicative DNA polymerase in… more
Abstract:DESCRIPTION (provided by applicant): This Phase 1 SBIR will develop a portable, non-invasive tool which will improve the diagnostic accuracy of kinetic shunt patency testing, including radionuclide studies or ShuntCheck tests, in pediatric hydrocephalus pa
tients. This will improve clinical care for… more
Abstract:DESCRIPTION (provided by applicant): The goal of this SBIR is to create the first comprehensive set of clinical tools and noninvasive methods for diagnosing cerebrospinal fluid (CSF) shunt obstruction and to validate them to convince clinicians of thei
r clinical value. Hydrocephalus is a common… more
Abstract:DESCRIPTION (provided by applicant): Hyperpolarized helium and xenon MRI of the lungs has been shown to provide useful physiological information about pulmonary function. Hyperpolarized helium imaging has been shown to provide outstanding imaging of lung g
as spaces while allowing for… more
Abstract:The overall purpose of the project is to create a comprehensive software package of adaptive statistical design and analysis methods for which no computational tools are currently available for use by Contract Research Organizations in clinical trial design and analysis. The goal is to create a… more
Abstract:The Volunteer, Employment, and Internship Web Solutions project will produce a web-based services that provide students with employment, volunteer, and internship opportunities to prevent students from dropping out of… more
Abstract:Through the Social Shape Up System teachers will use a handheld device to manage their classroom by monitoring and track classroom behaviors in pre-K to eighth grade classrooms. The product will include the curriculum consisting of eight research-based… more
Abstract:This project creates a service allowing speech-language pathologists (SLPs) to provide effective therapy services remotely via “telepractice,” using a web platform combining video conferencing technology with integrated therapy curriculum and practice management tools. Phase 1… more
Abstract:This project will develop the Presence Telecare intervention, a suite of tools to facilitate “remote telepractice” of speech language services that the company provides. The suite will include video conferencing technology integrated with therapy… more
Abstract:Readorium will develop a desktop software to support students struggling with reading comprehension in middle school science. The software teaches readers the special features of nonfiction text and strategies for reading comprehension. The games will include an… more
Abstract:DESCRIPTION (provided by applicant): The aim of this project is to develop a new technology that can be used to detect very low concentrations (femtomolar and below) of proteins that are diagnostic for cancer. Presently, early diagnosis of cancer is limite
d by the fact that the limits of detections… more
Abstract:Real-time measurements of particle species, including NO3-, NH4+, and SO4=, are needed at multiple locations in and beyond the NCORE network to understand pollutant fluxes and dynamics of PM2.5, and to constrain atmospheric models. Existing methods have proved… more
Abstract:DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) has increased the survival of children and adults afflicted with malignant and non-malignant hematological diseases. Prior to transplant, patients receive a conditioning re
gimen of cytotoxic drugs (e.g.… more
Abstract:DESCRIPTION (provided by applicant): Hormone refractory prostate cancer (HRPC) is a life threatening disease that cannot be treated with currently available drugs, most of which target interaction of androgen with the androgen receptor (AR). While there ar
e different mechanisms by which tumors… more
Abstract:DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is the most common cause of visual impairment of the elderly in developed countries. Despite its prevalence with the aging population, its etiology and pathogenesis are poorly unde
rstood and the treatment options are… more
Abstract:DESCRIPTION (provided by applicant): One specific focus and expertise of CalCyte Therapeutics Inc. is to develop and apply small molecule driven (i.e. chemically defined), stem cell based therapy to treat geographic atrophy (GA) from age-related macular de
generation (AMD). AMD affects 30-50 million… more
Abstract:DESCRIPTION (provided by applicant): More than 43 million Americans have a disability; of those, 18.6 million have visual disabilities, according to the National Fire Protection Association (Emergency Evacuation Planning Guide For People with Disabilities)
. Fire related incidents contribute to 1… more
Abstract:The importance of fast, reliable detection of pathogens in drinking water in the United States and worldwide, is increasing rapidly due to rising populations and increasing environmental degradation, as well as the threat of terrorism. Although the technology readiness level of rapid detection… more
Abstract:DESCRIPTION (provided by applicant): Essential Tremor (ET) is the single most common motion disorder, affecting 10 million people in the US alone. Due to the debilitating muscle movements associated with this disease, people with ET have difficulty in perf
orming daily functions such as eating and… more
Abstract:DESCRIPTION (provided by applicant): The goal of the current project is to develop and test a computerized attention training program (TAPAT-ATT) to meet the needs of patients with hemispatial neglect following stroke or traumatic brain injury. As a group,
these patients tend to have poorer… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop an offering designed to help early stage entrepreneurs identify their knowledge gaps, business risks and market challenges, and prescribe actionable measures that enable the entrepreneurs to reduce or ameliorate their risks,… more
Abstract:DESCRIPTION (provided by applicant): Our long-term goal is to develop a clinical instrument, the 2-photon ophthalmoscope, for non-invasive, high-resolution and repetitive imaging of biochemical processes within the human retina. Such an instrument will ha
ve tremendous potential for early detection… more
Abstract:DESCRIPTION (provided by applicant): The product that will result from this SBIR is a small molecule drug therapy for Alzheimer's Disease (AD) that works by inhibiting amyloid precursor protein synthesis. AD accounts for two-thirds of all dementia, afflic
ting more than 26 million people worldwide,… more
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