Abstract:DESCRIPTION (provided by applicant): In comparison to standard x-ray therapy, proton therapy allows an increased dose of radiation to a tumor and by reducing the amount of radiation to healthy tissue. As a result, it provides the best possible option for u
sing radiation to control and eliminate… more
Abstract:DESCRIPTION (provided by applicant): Squamous cell cancer of the head and neck (SCCHN) is locally invasive, and frequently spreads to the cervical lymph nodes. Locally advanced disease is treated with radiotherapy plus chemotherapy and/or cetuximab (an ant
i-EGF receptor antibody), but the cure rate… more
Abstract:DESCRIPTION (provided by applicant): In recent years there has been an increased interest in tapping the potential drug reservoir contained within the metagenome. To enable mammalian based screening of metagenomic libraries for novel drugs we have develope
d a method for bacterial delivery of… more
Abstract:DESCRIPTION (provided by applicant): Neuromuscular disorders, ranging from severe generalized diseases such as muscular dystrophy and amyotrophic lateral sclerosis (ALS) to localized conditions, including nerve injuries and radiculopathy, impact the lives
of millions of people in the US and around… more
Abstract:DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer related mortality in the United States, accounting for more than one-fourth of all cancer fatalities in 2008. Although there has been substantial progress in the understandin
g of the molecular biology and genetics of… more
Abstract:DESCRIPTION (provided by applicant): The aim of this submission is to develop a quantitative microRNA assay for screening right and left colon cancer in stool of patients, particularly at the early adenoma stage (e.g., polyps 3 1 cm with high grade dyspl
asia), which shows higher sensitivity than… more
Abstract:DESCRIPTION (provided by applicant): Fast Track SBIR Phase I and Phase II Exposure to centrally acting military nerve agents and organophosphorus (OP) pesticides are known to cause death and neurological damage (Coupland 2005, Karalliedee 1989, Buckley 200
4). Improved countermeasures to… more
Abstract:DESCRIPTION (provided by applicant): There is clear evidence that mitochondrial dysfunction and oxidative stress are precipitating and exacerbating factors in neurodegenerative diseases. The development and commercialization of radio frequency electron
ics for use in animal models of… more
Abstract:DESCRIPTION (provided by applicant): The Pediatric Vision Scanner (PVS) is a hand-held research prototype device that uses retinal birefringence scanning technology (co-invented by the PI) to diagnose the presence of amblyopia ( lazy eye ) and strabismus (
misaligned eyes). These medical eye… more
Abstract:DESCRIPTION (provided by applicant): Halsa has acquired the exclusive intellectual property rights to ZAG, a material naturally found in humans, which induces immediate and substantial depletion of body fat as well as control of diabetic symptoms. A growin
g set of evidence shows that this… more
Abstract:DESCRIPTION (provided by applicant): An overlooked, neglected, yet significant problem in the United States today is the use and abuse of tobacco, alcohol, and other drugs by individuals with intellectual disabilities (ID). Increasing numbers of people wit
h ID are living independently in the… more
Abstract:This Small Business Technology Transfer Phase I project will seek to improve the performance of the cathode materials used in lithium-ion (Li-ion) batteries. LiCoO2 is the primary cathode material, but it is relatively expensive, and has safety concerns. A safer alternative is LiMn2O4, but its… more
Abstract:DESCRIPTION (provided by applicant): PSMA is an important biomarker for prostate cancer prognosis and an appropriate target for therapy due to its restricted expression mainly on late-stage, androgen-independent and metastatic prostate cancer cells. While
currently there is only one clinical PSMA… more
Abstract:This Small Business Innovation Research Phase I project aims to increase the commercial use of high temperature superconductors (HTSs) by reducing component costs and increasing manufacturability. Specifically, the innovation is to produce high-quality HTS thin films on a new substrate material… more
Abstract:DESCRIPTION (provided by applicant): Our new president vows to address the pervasive issue of cancer. Over 1.4 million Americans will be diagnosed with cancer this year, joining over 10 million living Americans who have experienced cancer. The medical cos
ts of cancer care were 78 billion in 2008,… more
Abstract:DESCRIPTION (provided by applicant): Inhibitor of differentiation (Id) genes and proteins play a significant role in tumor biology, and an anti-Id therapy in combination with a taxanes, a widely prescribed class of cytotoxic (paclitaxel/docetaxel, docetaxe
l or protein-bound paclitaxel) to treat… more
Abstract:Electrical grids are overloaded on a daily basis due to peaking electrical demand. In order to satisfy this peak demand utilities fire-up expensive and polluting gas and oil stand-by generators. Billions of dollars are spent and wasted each year on this problem due to mismatched electrical average… more
Abstract:Electrical grids are overloaded on a daily basis due to peaking electrical demand. In order to satisfy this peak demand utilities fire-up expensive and polluting gas and oil stand-by generators. Billions of dollars are spent and wasted each year on this problem due to miss-matched electrical… more
Abstract:A need exists for a new environmental situational awareness sensor with multi-spectrum camouflage that is extremely small (90g) and capable of measuring with aviation-grade accuracy: wind speed/direction, horizontal visibility, sky condition, cloud heights, temperature, dewpoint, barometric pressure… more
Abstract:Anaerobic digestion (AD) of animal manure offers the potential of offsetting the declining natural gas fossil fuel reserves with renewable energy while abating odor and methane greenhouse gas emissions. However, two significant problems must be resolved prior to achieving that potential. Those… more
Abstract:DESCRIPTION (provided by applicant): Personalized methods are urgently needed for monitoring tumor status and assessing recurrence or treatment failure. Conventional means of monitoring include clinical signs, symptoms, laboratory results, and expensive te
sts such as radiographic imaging (CT scan,… more
Abstract:Bovine tuberculosis is a well-known zoonotic disease which affects cattle world-wide. Mycobacterium bovis (M. bovis), the causative agent of bovine tuberculosis (bTB), is a slow-growing bacteria, for which cattle are a host and significant reservoir. Consumption of raw milk and milk products has… more
Abstract:Acidosis in ruminant animals (beef cattle, dairy cows, and sheep)is a metabolic condition that causes problems for animals fed high-grain diets. Orally dosing animals with a strain of bacteria, Megasphaera elsdenii, has been shown to be beneficial in alleviating or decreasing this metabolic problem.… more
Abstract:DESCRIPTION (provided by applicant): Under the auspices of this small business innovation research (SBIR) grant, AuraSense LLC will develop a novel nanotechnology, Nano-flares , for the detection of low abundance microRNA (miR) species in living cells in
real-time. MicroRNAs are short (~22… more
Abstract:Current forest riparian protection practices within California and Washington mandate continuous buffer zones of relatively uniform width along all fish-bearing streams and along the lower reaches of many headwater streams. The scientific basis for most of these rules is typically drawn from broad… more
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