Abstract:An accurate prediction of aero-elastic effects depends on an accurate prediction of the unsteady aerodynamic forces. Perhaps the most difficult speed regime is transonic where the motion of the shock wave and its interaction with the boundary layer are dominant factors. In spite of over 40 years… more
Abstract:DESCRIPTION (provided by applicant): Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induceasthma, especially in children. The focus of… more
Abstract:DESCRIPTION (provided by applicant): To meet Agency requirement for reliable assessment of botulinum neuron toxin A (BoNT/A) in manufactured products, we propose to apply the fluorescent peptide beacon technology for measurement of both binding function and proteolytic function of the toxin in a… more
Abstract:DESCRIPTION (provided by applicant): We propose a new interventional device that solves a significant therapeutic bottleneck in the treatment of lens cataract in children. As the leading cause of childhood blindness, lens cataract interferes with the optical performance of the eye and if untreated,… more
Abstract:DESCRIPTION (provided by applicant): The present lack of blood-based diagnosis requires AD patients to be subjected to either invasive spinal fluid (CSF) tapping, expensive MRI or PET imaging, or arduous psychological testing, all unsuitable and costly forour elderly. Strategically, we shall address… more
Abstract:DESCRIPTION (provided by applicant): Development of tools to modify globin gene expression in stem cells The objective of this proposal is to develop a treatment for patients with sickle cell disease. The development of methods for treating common geneticdiseases, such as sickle cell disease remains… more
Abstract:DESCRIPTION (provided by applicant): This Phase II SBIR application is responsive to Program Announcement PA-09- 113, Manufacturing Processes of Medical, Dental and Biological Technologies . This PA solicits work on technology for the manufacture of implantable devices and materials, prosthetic… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a method to objectively measure immune reconstitution following hematopoietic stem cell transplantation using direct sequencing of the T-cell repertoire. This method willbe developed using data from patients treated… more
Abstract:CEL-031 is being developed as a novel, targeted tre8tment for non-mLiscle invasive bladder cancer (NMIBC). Bladder cancer is the 5th most common cancer in the US, with most cases diagnosed 8t the nonmuscle invasive stage. It is the most expensive cancerto treDt on a per patient basis. There is 8… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a miniature gas chromatography system that can detect pollutants in homes and businesses and interface to an HVAC system for indoor air quality (IAQ) control. The device will use air as a carrier gas, and will be priced… more
Abstract:The object of the proposed work is to develop better processes for the electrochemical conversion of CO2 into a high value chemical in a growing market. CO2 is one of the key causes of global warming. If we can recycle CO2 back into useful products, than the costs of meeting the Nations global… more
Abstract:ABSTRACT: The AF has a need for vapor intrusion alarms. Dioxide proposes a device that uses a preconcentrator, microGC and novel detector. The device will use The TO-15/17 protocol to scan for the compounds of interest to the air force. BENEFIT: This device will be useful for indoor air… more
Abstract:Nimbis Services Inc. proposes to provide an open portal development environment for developers, hosting service for the portal products and end user web based ecommerce access, integrated with Nimbis Services current brokerage service, that will broaden the use of digital analysis computing or model… more
Abstract:DESCRIPTION (provided by applicant): Goals: The goal is to develop a computational system to predict the targets toward which small molecules are biased. The tool will optimize biased libraries, prioritize them for testing against particular targets, identify targets in phenotypic screens, and allow… more
Abstract:The injuries to warfighters caused by Improved Explosive Devices and snipers are often associated with significant loss of long and/or maxillofacial bones. Effective treatment and recuperation necessitates the replacement of these missing bone structures. We are developing a device which once… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will explore, design, and implement a novel flexible ultrasound transducer-based nondestructive inspection and monitoring system to improve and simplify the inspection of curved and non-planar structures. Ultrasound is ideally suited to… more
Abstract:DESCRIPTION (provided by applicant): External fetal heart monitors (FHM) allow for intermittent or continuous monitoring of fetal status both before and during labor, and reduce medical costs by allowing fewer nurses or midwives to manage larger number patients. However, current external FHMs are… more
Abstract:This project develops a system to provide auxiliary sensory feedback in the lower limbs of amputees and enhance sensory function for individuals with disabilities through functional capacity and thereby improve their mobility and quality of life. The Farus sensory feedback system detects force loads… more
Abstract:Farus, LLC proposes to develop a novel burn assessment tool based upon THz imaging that will be aid in determining severity and boundaries. THz is ideally suited to burn wound imaging because it is extremely sensitive to water, robust to scattering, non-ionizing, and does not require contrast agents… more
Abstract:Ultrasound guidance procedures, such as central line placement and needle biopsy, require considerable skill to precisely position a needle while simultaneously holding a transducer. Finger-mounted ultrasound (FMUS) transducer array probes may potentially improve the workflow requirements of… more
Abstract:DESCRIPTION (provided by applicant): This is a proposal to collect the necessary data for FDA regulatory approval of the Cytonics assay as a diagnostic tool to identify patients who will respond to steroid injection therapy for LBP due to radiculopathy. Low back pain (LBP) syndromes include spinal… more
Abstract:Multiplex assays will be developed for identifying Leishmania from sand flies and for determining the species of the parasites. A multiplex PCR will be developed to amplify the gene loci needed to distinguish the closely related species of the pathogenic species. Analysis of the PCR products will be… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will substantially and rapidly increase environmental and food safety by testing the feasibility of using carbon nano-tube covered sensors to electrochemically detect the amount of mercury in substances such as water or fish, by… more
Abstract:Next generation military communication beyond Increment 1 will need to operate in a number of hostile and complex environments. These communication needs include secure relay of imagery data, precedence communications, and dynamic reconfigurability to changing wireless attacks. With increasing use… more
Abstract:DESCRIPTION (provided by applicant): Immunoglobulin A (IgA) nephropathy (IgAN) is one of the most common glomerulopathies worldwide, leading to kidney failure in up to 40% of those affected. This illness is caused by inflammation of the kidney brought about by extensive IgA1 protein deposits in all… more
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