Abstract:Wavelength-division multiplexing has been employed to great success in long-haul transmission systems to increase capacity and provide a new means (wavelength) of routing. Their application to local-area networks (LANs) on aircraft is promising due to the light weight and narrow cross section of… more
Abstract:Fiber-optic gyroscopes (FOGs) are used as the fundamental building block for high-precision inertial and angular displacement sensors in applications ranging from missile and UAV to war-plane and satellite navigation. The nonlinearity-induced non-reciprocity in FOGs is recognized as the critical… more
Abstract:Rapid tuning of narrowband sources is inherently limited by the number of roundtrips required in the high-Q cavity, which is required for generation of a narrow lasing linewidth. We propose to break the cavity tuning/linewidth barrier presented by conventional reconfiguration of the physical cavity… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop and commercialize a novel biologic therapy for the treatment of allergic disease and particularly allergic asthma. Specifically, this proposal will provide the critical immunogenicity, mechanistic and biomarker data… more
Abstract:Lightweight robotic excavators address the need for machines that dig,collect, transport and dump lunar soil. Robust and productive smallrobots enable mining rich and accessible deposits of ice and othervolatiles buried near craters at the lunar poles, delivering resources toproduce propellant, and… more
Abstract:A scalable gravity offload device simulates reduced gravity for the testing of various surface system elements such as mobile robots, excavators, habitats, and deployables in a relevant environment. The device is capable of simulating reduced gravity over an arbitrary terrain including such… more
Abstract:DESCRIPTION (provided by applicant): We propose a novel technique to identify and capture circulating tumor cells (CTCs) using engineered adenoviruses and sophisticated flow cytometry. Current techniques for detection of CTCs include reverse transcriptase-polymerase chain reaction (RT-PCR), flow… more
Abstract:DESCRIPTION (provided by applicant): Lab-on-a-chip flow cytometer using color-space-time (CoST) coding method NanoSort, LLC RESEARCH and RELATED Other Project Information 7. PROJECT SUMMARY Fluorescence-activated-cell-sorting (FACS) or flow cytometry enables clinicians and researchers to… more
Abstract:This Phase I, SBIR contract is for the development of a customized lab-on-a-chip fluorescense activated cell sorter (FACS) system that will provide on-chip antibody labeling, enumeration, and sorting of CTCs suitable for downstream molecular analysis. Theaim is to further understand cancer biology… more
Abstract:Mars Sample Return poses some of the most challenging operational activities of any NASA deep space mission. Rendezvous of a vehicle with a sample canister in order to return the canister to Earth requires a variety of complex mathematical processing on a changing data set, coupled with the need to… more
Abstract:DESCRIPTION (provided by applicant): This project will develop a dynamic quantitative phase-imaging interference 4D microscope system to enable creating phase image movies and quantifying motion of live cells and cellular processes in vitro using harmlesslight levels without the need for adding… more
Abstract:We propose to develop an extended lateral range capability for a dynamic optical profiling system to enable non-contact, surface roughness measurement of large and aspheric astronomical optics in-situ during manufacture. This instrument will be capable of measuring more than three decades of… more
Abstract:Critical to the success of delivering on the promise of deep space optical communications is the creation of a stable and reliable high power multichannel optical uplink/beacon. Optical Engines proposes to deliver in phase 2 2 compact and low cost fiber amplifiers suited to the uplink application.… more
Abstract:ABSTRACT: During the phase 1 program, Optical Engines, Inc. has demonstrated the key components necessary to create an ultra compact multi kW Yb based PM PCF amplifier. These components include a 3 fiber coupled laser diode stack with an aggregate power output of over 1200 W at 976nm, an etched… more
Abstract:DESCRIPTION (provided by applicant): This is a Fast-Track application to develop a web-based, patient-centered software product that accurately assesses a patient's perioperative risk as a means of improving quality of care and reducing costs. Approximately 40 million surgical… more
Abstract:DESCRIPTION (provided by applicant): The application's broad, long-term objectives are to develop a rapid, high-throughput clinical assay for 3' fibrinogen that will be used to assess the risk of a patient developing venous thromboembolism. This assay willguide clinical management,… more
Abstract:DESCRIPTION (provided by applicant): Nearly half of all college students have a diagnosable mental health problem (Blanco et al., 2008). College counseling centers (CCCs) are faced with increasing demands for services from Universities, students and parents to meet the treatment needs of their… more
Abstract:This proposal by Jansen's Aircraft Systems Controls, Inc. presents an innovative solution for Active Combustion Control.Relative to the state of the art, this concept has the ability to provide frequency modulation (greater than 1000[Hz]) in combination with high amplitude modulation (in excess… more
Abstract:This Small Business Innovation Research Phase I project proposes a revolutionary approach to extending the lifetime of microchannel plate (MCP) photomultiplier tubes (PMTs) using atomic layer deposited (ALD) nanofilms to suppress the creation of damaging positive ions. The technical and intellectual… more
Abstract:Atomic layer deposited functional nano-film technology is used to manufacture Microchannel plate (MCP) devices capable of high gain / low ion feedback operation, on glass capillary array substrates, as a means to replace MCP chevron configuration and enable direct photocathode deposition (e.g. GaN)… more
Abstract:The work proposed in this SBIR proposal is is synergistic with the, DOE funded, basic R & amp;D effort of a consortium of national laboratories, universities, and industry, led by Argonne National Laboratory and the University of Chicago for the development of new, large area, photodetector… more
Abstract:DESCRIPTION (provided by applicant): Analogs of the neuropeptide somatostatin are important therapeutics for the treatment of hormone secreting tumors with annual sales in excess of 1.3B. However, currently available peptide depots are only effective in approximately half the patients with growth… more
Abstract:DESCRIPTION (provided by applicant): Up to 30% of the US population are now affected by nasal allergy, resulting in a total (direct and indirect) cost of approximately 14.6 billion per year. Seasonal allergic rhinitis (AR), due to exposure to airborne pollen and molds is a major component of this… more
Abstract:Over 60% of cancer patients are treated with radiotherapy, yet radiation-induced normal tissue damage can cause organ dysfunction and morbidity. Radiotherapy of CNS tumors is problematic due to potential for diminished neurological function or mental retardation. Our proprietary thrombin-derived… more
Abstract:DESCRIPTION (provided by applicant): For this SBIR Limaging, LLC teams with researchers in Ophthalmology at the Wilmer Eye Institute at Johns Hopkins University to develop DBillScan, a camera phone based currency reader to identify U.S. dollar bills for the blind and visual impaired (VI). In many… more
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