Abstract:Background: Surgical error reduction requires addressing rapid adoption of new surgical technology. We propose development of a networked surgical assessment platform able to collect performance and outcomes data from multiple surgical platforms and sites for dynamic metrics analysis. Goal:… more
Abstract:The ongoing military conflicts demonstrate the need to deploy skilled personnel equipped with advanced technology to provide medical and surgical attention as close as possible to the point of injury. A major problem is the occasional mismatch between the type of injury and the type of surgeon… more
Abstract:Our goal is to design and build a lightweight, wide area passive standoff imaging detection system capable of rapidly detecting liquids on surfaces for the purpose of contamination avoidance and reconnaissance. The envisioned technology extends the advantages of wide area passive infrared sensing… more
Abstract:Project goal is to develop and demonstrate a chemical/explosive sensor system to provide enhanced detection and classification in missions for which acoustic or optical imaging alone are not effective. The chemical sensor package developed and delivered during this SBIR effort will be lightweight,… more
Abstract:Ceebus Technologies is proposing a development plan to monitor diver vital biometric data and collect SCUBA status data, store the data, analyze and compare the data to normal, generate alerts or alarms if necessary, send the data to other underwater diver teammates and to a surface vessel. Sensors… more
Abstract:A continuing and growing threat to U.S. military personnel and civilians is exposure to toxic chemicals and pathogens. Useful detection systems exist, but it remains imperative to investigate next-generation technologies that have the potential to improve by an order of magnitude the cost,… more
Abstract:A continuing and growing threat to U.S. military personnel and civilians is exposure to toxic chemicals and pathogens. Because of this, detection of exposure to chemical and biological agents is a priority for biodefense, combat readiness, and public health. One promising approach is to measure… more
Abstract:DESCRIPTION (provided by applicant): More than 43,000 Americans die each year from liver disease, making it the 10th leading disease- related cause of death in the US. Cirrhosis with irreversible injury and scarring of the liver is the most prevalent causeof liver failure and is attributable to… more
Abstract:DESCRIPTION (provided by applicant): There is a worldwide consensus that islet transplantation may be considered a viable option for the treatment of insulin-dependent diabetes mellitus, and clinical trials are underway at many centers around the world. Asthis approach for curing diabetes… more
Abstract:DESCRIPTION (provided by applicant): Twenty four million Americans are affected with end-stage lung disease which is the 4th leading cause of death in the US, and there are currently 2,122 candidates on the lung transplant waiting list. Emphysema and chronic obstructive pulmonary disease are the… more
Abstract:DESCRIPTION (provided by applicant): Vascular grafting is performed clinically to repair or replace diseased coronary artery and peripheral vessels to restore normal blood flow patterns. Synthetic grafts composed of polymers such as Dacron and expanded polytetrafluoroethylene do not work well in… more
Abstract:DESCRIPTION (provided by applicant): Tissue digestion and cell extraction is a core element of a variety of bioprocessing methods ranging from isolation of the rare cancer stem cell for basic research to the purification of human islets or adipose-derivedmesenchymal stem cells for transplant. While… more
Abstract:DESCRIPTION (provided by applicant): The cultured cell has emerged as a critical link in the translation of research in the various fields of biotechnology and biomedicine. An unprecedented increase in the demand for cultured cell products is now drivenby the growth in biopharmaceuticals, cancer… more
Abstract:DESCRIPTION (provided by applicant): The results of early clinical trials using stem cells clearly offer the promise of a new path to addressing a variety of medical problems that range from creating engineered tissues for autologous grafts to repairing a variety of organs. Mesenchymal stem… more
Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is to complete development of a Microfluidic Liver Array (MLA) platform for improved and lower cost in vitro toxicity screening targeting the human liver. This funding will directly lead tothe commercialization of a product with … more
Abstract:DESCRIPTION (provided by applicant): Targeted therapies have the ability to specifically interact with and block proliferation of cancer cells by interfering with targeted gene products required for the malignant phenotype. Unlike conventional cancer chemotherapies, targeted therapies do not harm… more
Abstract:With the rapid strides in various avionics-related technologies, the need for advanced simulators will increase. Anti-jam receiver development and future improvements in PNT are critically dependent on the availability of advanced simulators. The needs include: flexible, accurate, adaptable,… more
Abstract:TRS Technologies proposes to develop a very wideband ultrasound diagnostic tool for quantification of trabecular bone properties for astronauts in long term space missions. Loss of calcification in bones and general loss of strength must be monitored in missions to insure personnel health, however,… more
Abstract:TRS Technologies, Inc. proposes to develop high energy density capacitors with stable dielectric properties for utilization in pulse power systems. The proposed ceramic capacitor will combine the best features of high energy density, low dielectric loss and high reliability. The capacitors… more
Abstract:TRS Technologies proposes to develop high duty cycle, compact single crystal transducers for vector projectors. TRS will work with Penn State ARL in evaluating new single crystal compositions for high temperature and drive, as well as evaluate passive materials used in transducer construction under… more
Abstract:The advanced relaxor-PT piezoelectric crystals, Mn:PIN-PMN-PT (manganese doped Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3), were initially developed by TRS and immediately attracted broad attention for the next generation of high power SONAR transducers due to their greatly improved… more
Abstract:TRS Technologies has developed high energy density materials and components for Ferroelectric Generators (FEGs). Our technology is based on advanced materials and processing resulting in high quality ferroelectrics with high mechanical and electrical strength. For this program, we will use these… more
Abstract:This Small Business Innovation Research Phase I project highlights a strategy for the development of the first integrated high throughput pipeline to synthesize and evaluate novel sugar-drug conjugates. The core innovation of this proposed phase I study is an enzyme catalyzed one-step glycosylation… more
Abstract:DESCRIPTION (provided by applicant): Non-small cell lung cancer (NSCLC) is among the most common and lethal cancers yet, the current standard of care for advanced stage NSCLC provides only modest improvements in overall survival or quality of life. Thus,there exists a significant unmet need for new… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop an innovative, cost-effective, oil quality sensor that can detect when and how engine oil becomes degraded, as an integral part of a smart engine health monitoring system. Current sensors typically work only with a specific… more
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