Abstract:DESCRIPTION (provided by applicant): This is an application to develop a scalable computational infrastructure to enable virtual screening of chemical libraries using the Amazon EC2 cloud computing environment and automated docking tools. Structure-based virtual screening is an important tool in the… more
Abstract:DESCRIPTION (provided by applicant): Long-term enteral nutrition, via a feeding tube, is often provided to pediatric patients who have a functioning gastrointestinal tract but are at risk of malnutrition due to their inability to properly ingest nutrientsorally. Enteral feeding can be accomplished… more
Abstract:DESCRIPTION (provided by applicant): AMPA glutamate receptors mediate the majority of fast excitatory neurotransmission in the brain. Four AMPA receptor subunits exist, GluR1-GluR4, with functional channels containing various combinations of these foursubunits. In hippocampal and cortical… more
Abstract:DESCRIPTION (provided by applicant): Amyotrophic lateral sclerosis (ALS) is characterized by the progressive and selective loss of motor neurons (MNs) in the motor cortex, brainstem, and spinal cord, resulting in death of patients typically 2-5 years after diagnosis. Glutamate-mediated… more
Abstract:DESCRIPTION (provided by applicant): Respiratory distress syndrome (RDS) is an acute, severe pulmonary disorder that is the leading cause of morbidity and mortality in preterm infants. It is a major healthcare concern - costs associated with treatment of RDS and its complications exceed 2.4 billion… more
Abstract:DESCRIPTION (provided by applicant): Tobacco use is now recognized as the single most responsible cause of avoidable death worldwide representing approximately 10% of all deaths globally. Directly or indirectly, long term tobacco use has been implicated incomplex major health disorders such as… more
Abstract:DESCRIPTION (provided by applicant): The ultimate aim of this project is to produce a drug for the prevention and treatment of heparin induced thrombocytopenia and thrombosis (HITT), a serious complication of heparin therapy for which there is currently nospecific treatment. Heparin is a… more
Abstract:DESCRIPTION (provided by applicant): Indoor air quality (IAQ) is of rising concern as indoor air pollutants can pose significant health risks, including asthma, sensitization, allergies, fatigue, cancer and the transmission of airborne diseases. IAQ is especially important in health care facilities.… more
Abstract:Integran USA (Pittsburgh, PA) is pleased to provide this proposal in response to the Small Business Innovation Research (SBIR) Request for Proposal (RFP) DLA10-001)"Advanced Technologies for Discrete-Parts Manufacturing"to develop a manufacturing process for allowing the further use of… more
Abstract:An amorphous metal matrix composite, consisting of a Ni-W (nickel-tungsten) amorphous matrix with second phase hard ceramic WC (tungsten-carbide) particles is proposed as an new class of metallic glass material. By leveraging Integran Technology USA"s expertise in the synthesis of… more
Abstract:The successful execution of this Phase I initiative will develop an optimized electromagnetic interference (EMI) and radio frequency interference (RFI) shielding fabric by electrodepositing metallic micro-layers of copper and a newly developed nanocrystalline ferromagnetic shielding alloy (Nanovate… more
Abstract:The RON and c-MET signal pathways are critical regulators of cell growth, survival, migration, differentiation, and drug resistance. High levels of activated RON or c-MET have been observed in a number of human cancers. Activation of RON and c-MET by phosphorylation initiates a signal transduction… more
Abstract:In response to this NCI solicitation, Rockland proposes to develop a novel method to assay the pharmacodynamic (PO) properties of anti-cancer small molecules targeting the PI3K/mTOR/AKT signaling pathway by quantitatively and independently measuring the phosphorylation of each unique AKT isoform in… more
Abstract:This Proposal addresses the need for high average power (HAP), near-diffraction-limited laser sources for laser stripping applications, an important process for going forward with plans to build an 8 GeV H- to proton injector source for driving upgraded Fermi National Accelerator Laboratory proton… more
Abstract:This topic addresses the need for compact efficient solid-state deep ultraviolet (UV) lasers operating in the wavelength range of 220-250 nm, for use in Raman systems for chemical and biological detection. The laser to be developed would also be very useful in the detection of explosives. We propose… more
Abstract:Frac fluids are viscous solutions that are pumped under high pressure to fracture subsurface formations for recovery of natural gas. As it is pumped to the surface, the flowback water picks up large quantities of various contaminants that make it difficult to dispose or recycle. Though this water… more
Abstract:As an effort to improve market efficiency for local food, expand potential market space, increase profitability for small and medium-sized farms (SMFs), and ensure food safety along the value chain, Eden's Bowl proposes this project to research economic and technical feasibility of an… more
Abstract:SID Technologies is developing intradermal devices aiding healthcare workers in performing intradermal injections. The goal is to provide an alternative, easier to learn method of intradermal drug delivery to the Mantoux technique, in order to expand the population of healthcare workers who may… more
Abstract:The strength of this submission lies in the breadth and depth of knowledge provided by the members of the consortium. It includes Magnet Applications, one of the remaining magnet and assembly manufacturers in the US, - Magnomatics, whose core business is developing applications based on magnetic… more
Abstract:The primary objective of this Phase I project is to develop radar-based techniques and algorithms to accurately estimate the parameters of walls, such as dielectric constant, conductivity (or loss-tangent) and thickness, as well as to devise methods that can characterize inhomogeneous walls by… more
Abstract:Armored vehicle crewmen, particularly drivers, have always been challenged by limited visibility. Vision blocks provide narrow and restricted views of the outside world and can severely impair driver performance, especially when operating at higher speeds and in complex urban environments. Drivers… more
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